Cortical–Hypothalamic Integration of Autonomic and Endocrine Stress Responses

Schaeuble, Derek; Myers, Brent

doi:10.3389/fphys.2022.820398

Cited by 23 publications

(12 citation statements)

References 106 publications

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“…The responses evoked by stressful stimuli are mediated by limbic networks in the central nervous system involving cortical, subcortical, hypothalamic, and brainstem structures ( Dampney, 2015 ; Myers, 2017 ; Schaeuble and Myers, 2022 ). In this sense, the insular cortex (IC) has been described as a part of the brain network implicated in the integration and processing of limbic information in humans subjects and animals ( Augustine, 1996 ; Nieuwenhuys, 2012 ; Uddin, 2014 ; Gogolla, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats

et al. 2022

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The insular cortex (IC) has been described as a part of the central network implicated in the integration and processing of limbic information, being related to the behavioral and physiological responses to stressful events. Besides, a site-specific control of physiological functions has been reported along the rostrocaudal axis of the IC. However, a functional topography of the IC in the regulation of stress responses has never been reported. Therefore, this study aimed to investigate the impact of acute restraint stress in neuronal activation at different sites along the rostrocaudal axis of the IC. Furthermore, we evaluated the involvement of IC rostrocaudal subregions in the cardiovascular responses to acute restraint stress. We observed that an acute session of restraint stress increased the number of Fos-immunoreactive cells in the rostral posterior region of the IC, while fewer activated cells were identified in the anterior and caudal posterior regions. Bilateral injection of the non-selective synaptic inhibitor CoCl2 into the anterior region of the IC did not affect the blood pressure and heart rate increases and the sympathetically mediated cutaneous vasoconstriction to acute restraint stress. However, synaptic ablation of the rostral posterior IC decreased the restraint-evoked arterial pressure increase, whereas tachycardia was reduced in animals in which the caudal posterior IC was inhibited. Taken together, these pieces of evidence indicate a site-specific regulation of cardiovascular stress response along the rostrocaudal axis of the IC.

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Section: Introductionmentioning

confidence: 99%

Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats

et al. 2022

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“…Finally, prefrontal cortex may be important in conveying highly processed sensory information to the hypothalamus in general (e.g., (88,89)), though no major efferent pathways to the hypothalamus from the avian analog have yet been described. An important next step will be using intersectional tracing approaches to identify brain regions that link auditory pallium and the VMHl.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the medial acropallium is also thought to be analogous to the mammalian medial amygdala (84–86); in mammals the medial amygdala is thought to route salient olfactory sensory information from pallium to the VMH to guide decision-making (87). Finally, prefrontal cortex may be important in conveying highly processed sensory information to the hypothalamus in general (e.g., (88, 89)), though no major efferent pathways to the hypothalamus from the avian analog have yet been described. An important next step will be using intersectional tracing approaches to identify brain regions that link auditory pallium and the VMHl.…”

Section: Discussionmentioning

confidence: 99%

Top-down, auditory pallial regulation of the social behavior network

Spool

Lally

Remage‐Healey

2023

Preprint

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Social encounters rely on sensory cues that carry nuanced information to guide social decision-making. While high-level features of social signals are processed in the telencephalic pallium, nuclei controlling social behaviors, called the social behavior network (SBN), reside mainly in the diencephalon. Although it is well known how mammalian olfactory pallium interfaces with the SBN, there is little information for how pallial processing of other sensory modalities can modulate SBN circuits. This is surprising given the importance of complex vocalizations, for example, for social behavior in many vertebrate taxa such as humans and birds. Using gregarious and highly vocal songbirds, female Zebra finches, we asked to what extent auditory pallial circuits provide consequential input to the SBN as it processes social sensory cues. We transiently inactivated auditory pallium of female Zebra finches during song playback and examined song-induced activation in SBN nuclei. Auditory pallial inactivation impaired responses to song specifically within the lateral ventromedial nucleus of the hypothalamus (VMHl), providing the first evidence in vertebrates of a connection between auditory pallium and the SBN. This same treatment elevated feeding behavior, which also correlated with VMHl activation. This suggests that signals from auditory pallium to VMHl can tune the balance between social attention and feeding drive. A descending influence of sensory pallium on hypothalamic circuits could therefore provide a functional connection for the integration of social stimuli with internal state to influence social decision-making.

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“…Projections to the PVN from various brain regions, including the amygdala and the mPFC, the brainstem, and other hypothalamic brain regions, also affect PVN activation. These projections are activated under stress, thereby promoting the release of CRH, and further, ACTH and GCs, from the HPA axis, which ultimately act on peripheral organs [ 84 ]. The PVN, in addition to the neuroendocrine system, is also involved in the sympathetic network.…”

Section: Stress Accelerates Tumor Progression Via the Hpa Axismentioning

confidence: 99%

The Central Nervous Mechanism of Stress-Promoting Cancer Progression

Hong

Zhang²,

Liu³

et al. 2022

IJMS

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Evidence shows that stress can promote the occurrence and development of tumors. In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body’s immune response, causing tumor cells to escape the “surveillance” of the immune system. However, the perception of stress occurs in the central nervous system (CNS) and the role of the central nervous system in tumor progression is still unclear, as are the underlying mechanisms. This review summarizes what is known of stress-related CNS-network activation during the stress response and the influence of the CNS on tumors and discusses available adjuvant treatment methods for cancer patients with negative emotional states, such as anxiety and depression.

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Cortical–Hypothalamic Integration of Autonomic and Endocrine Stress Responses

Cited by 23 publications

References 106 publications

Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats

Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats

Top-down, auditory pallial regulation of the social behavior network

The Central Nervous Mechanism of Stress-Promoting Cancer Progression

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