Cortical processing of configurally perceived odor mixtures

Wilson, Donald A.; Fleming, Gloria; Vervoordt, Samantha M.; Coureaud, Gérard

doi:10.1016/j.brainres.2019.146617

Cited by 17 publications

(17 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study provides original insights into the peripheral contribution to odor mixtures' perception, by focusing on the AB and A'B' mixtures initially characterized as perceived configurally and elementally, respectively, in both human adults and newborn rabbits, and also more recently in adult rodents [20]; this by using here the same concentrations and ratios of components for acquisition of electrophysiological and behavioral data. At the same time, the use of MP as a reference stimulus led us to observe the peripheral processing of this pheromone.…”

Section: Discussionmentioning

confidence: 99%

“…The stimuli were the mammary pheromone (MP; 2-methylbut-2-enal; CAS# 497-03-0), ethyl isobutyrate (odorant A; CAS# 97-62-1), ethyl maltol (odorant B; CAS# 4940-11-8), and their mixtures (all the odorants were purchased from Sigma-Aldrich; Saint-Quentin-Fallavier, France). The latter were AB (30/70 ratio), which was reported as generating a configural perception of a pineapple odor in human adults (e.g., [19,53]), adult mice [20], and weak configural perception in newborn rabbits (e.g., [16][17][18]22]), and A'B' (68/32 ratio), which generates elemental perception in both human adults [19,53], mice [20] and newborn rabbits (e.g., [16][17][18]22]).…”

Section: Stimulimentioning

confidence: 97%

“…Strikingly, elemental and configural perceptions are both functional from early in life. Thus, newborn rabbits perceive weak configurally a binary AB mixture of element A (ethyl isobutyrate) and B (ethyl maltol) [16][17][18], which is also perceived configurally in human adults [e.g., 19] and adult mice [20]. The ratio of components is a crucial factor in this perception.…”

Section: Introductionmentioning

confidence: 98%

“…The ratio of components is a crucial factor in this perception. Indeed, the AB configural perception requires a 30/70 ratio of A/B (AB mixture) while a 68/32 ratio (A'B' mixture) elicits the AB elemental perception in newborn rabbits [21]; see [19] and [20] for convergent results in humans and mice. While some neurophysiological corollaries of AB and A'B' differentiated perceptions have been found in the newborn rabbit brain [22], the question of the processing of these mixtures at the peripheral level and the contribution of this level to elemental vs. configural perception has remained unexplored so far.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Brief olfactory learning drives perceptive sensitivity in newborn rabbits: New insights in peripheral processing of odor mixtures and induction

Duchamp‐Viret

Boyer

Villa

et al. 2021

Physiology & Behavior

Self Cite

View full text Add to dashboard Cite

Perception of the wide, complex and moving odor world requires that the olfactory system engages processing mechanisms ensuring detection, discrimination and environment adaptation, as early as the peripheral stages. Odor items are mainly elicited by odorant mixtures which give rise to either elemental or configural perceptions. Here, we first explored the contribution of the peripheral olfactory system to configural and elemental perception through odorant interactions at the olfactory receptor (OR) level. This was done in newborn rabbits, which offer the opportunity to pair peripheral electrophysiology and well characterized behavioral responses to two binary mixtures, AB and A'B', which differ in their component ratio (A: ethyl isobutyrate, B: ethyl maltol), and that rabbit pups respectively perceived configurally and elementally. Second, we studied the influence on peripheral reactivity of the brief but powerful learning of one mixture component (odorant B), conditioned by association with the mammary pheromone (MP), which allowed us to assess the possible implication of the phenomenon called induction in neonatal odor learning. Induction is a plasticity mechanism expected to alter both the peripheral electrophysiological responses to, and perceptual detection threshold of, the conditioned stimulus. The results reveal that perceptual modes are partly rooted in differential peripheral processes, the AB configurally perceived mixture mirroring odorant antagonist interactions at OR level to a lesser extent than the A'B' elementally perceived mixture. Further, the results highlight that a single and brief MP-induced odor learning episode is sufficient to alter peripheral responses to the conditioned stimulus and mixtures including it, and shifts the conditioned stimulus detection threshold towards lower concentrations. Thus, MP-induced odor learning relies on induction phenomenon in newborn rabbits.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Stimulimentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brief olfactory learning drives perceptive sensitivity in newborn rabbits: New insights in peripheral processing of odor mixtures and induction

Duchamp‐Viret

Boyer

Villa

et al. 2021

Physiology & Behavior

Self Cite

View full text Add to dashboard Cite

show abstract

“…In practice, therefore, it may be best if odors used in OVR exposure therapy are presented at low concentrations. This may be especially helpful during the early stages of introducing a trigger odor during desensitization training, as it has been shown that the concentration of an odorant can alter both its perceptual and neurological processing [106]. On the other hand, when presenting benign odors in OVR training for evoking a calm and pleasant distraction, higher than average concentrations may be preferable.…”

Section: Odor Perception Considerationsmentioning

confidence: 99%

Olfactory Virtual Reality: A New Frontier in the Treatment and Prevention of Posttraumatic Stress Disorder

Herz

2021

Brain Sciences

View full text Add to dashboard Cite

This perspective piece reviews the clinical condition of posttraumatic stress disorder (PTSD), which is currently increasing due to the COVID-19 pandemic, and recent research illustrating how olfaction is being incorporated into virtual reality (VR) platforms. I then discuss the latest work examining the potential of olfactory virtual reality (OVR) for the treatment of PTSD. From this foundation I suggest novel ways in which OVR may be implemented in PTSD therapy and harnessed for preventing the development of PTSD. Perceptual and chemical features of olfaction that should be considered in OVR applications are also discussed.

show abstract