Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval

Tanaka, Kazumasa Z.; Pevzner, Aleksandr; Hamidi, Anahita; Nakazawa, Yuki; Graham, Jalina A.; Wiltgen, Brian J.

doi:10.1016/j.neuron.2014.09.037

Cited by 339 publications

(309 citation statements)

References 31 publications

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“…Given the highly parallel nature of neural connectivity and processing, it is possible that although these ensembles may be sufficient for retrieval, they are not necessary as other pathways could compensate. The question of necessity was addressed in two recent studies using a light-gated proton pump from archaebacteria (ArchT) to hyperpolarize and silence cfos tagged neural ensembles in experiments analogous to those described above with ChR2 (Denny et al 2014;Tanaka et al 2014). Both teams of investigators also used context fear conditioning and examined the requirement for ensembles in three different hippocampal regions, the DG, CA3, and CA1.…”

Section: Memory Retrieval In Mice and Menmentioning

confidence: 99%

Memory Retrieval in Mice and Men

Ben-Yakov

Dudai

Mayford

2015

Cold Spring Harb Perspect Biol

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Retrieval, the use of learned information, was until recently mostly terra incognita in the neurobiology of memory, owing to shortage of research methods with the spatiotemporal resolution required to identify and dissect fast reactivation or reconstruction of complex memories in the mammalian brain. The development of novel paradigms, model systems, and new tools in molecular genetics, electrophysiology, optogenetics, in situ microscopy, and functional imaging, have contributed markedly in recent years to our ability to investigate brain mechanisms of retrieval. We review selected developments in the study of explicit retrieval in the rodent and human brain. The picture that emerges is that retrieval involves coordinated fast interplay of sparse and distributed corticohippocampal and neocortical networks that may permit permutational binding of representational elements to yield specific representations. These representations are driven largely by the activity patterns shaped during encoding, but are malleable, subject to the influence of time and interaction of the existing memory with novel information.

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Section: Memory Retrieval In Mice and Menmentioning

confidence: 99%

Memory Retrieval in Mice and Men

Ben-Yakov

Dudai

Mayford

2015

Cold Spring Harb Perspect Biol

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“…Similar to cocaine CPP, the dHPC, and in particular the CA1 region has a critical role in acquisition and expression of contextual fear memory (Goshen et al, 2011;Tanaka et al, 2014), but whether changes in dHPC brevican levels affect this memory is unknown. One week after the CPP remote test, the same groups underwent contextual FC (Figure 6d).…”

Section: Overexpression Of Brevican In the Dhpcmentioning

confidence: 99%

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

Lubbers

Matos

Horn

et al. 2015

Neuropsychopharmacol

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Cocaine-associated environmental cues sustain relapse vulnerability by reactivating long-lasting memories of cocaine reward. During periods of abstinence, responding to cocaine cues can time-dependently intensify a phenomenon referred to as 'incubation of cocaine craving'. Here, we investigated the role of the extracellular matrix protein brevican in recent (1 day after training) and remote (3 weeks after training) expression of cocaine conditioned place preference (CPP). Wild-type and Brevican heterozygous knock-out mice, which express brevican at~50% of wild-type levels, received three cocaine-context pairings using a relatively low dose of cocaine (5 mg/kg). In a drug-free CPP test, heterozygous mice showed enhanced preference for the cocaine-associated context at the remote time point compared with the recent time point. This progressive increase was not observed in wild-type mice and it did not generalize to contextualfear memory. Virally mediated overexpression of brevican levels in the hippocampus, but not medial prefrontal cortex, of heterozygous mice prevented the progressive increase in cocaine CPP, but only when overexpression was induced before conditioning. Postconditioning overexpression of brevican did not affect remote cocaine CPP, suggesting that brevican limited the increase in remote CPP by altering neuro-adaptive mechanisms during cocaine conditioning. We provide causal evidence that hippocampal brevican levels control time-dependent enhancement of cocaine CPP during abstinence, pointing to a novel substrate that regulates incubation of responding to cocaine-associated cues.

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“…When the mice were returned to the safe cage, they froze in fear, showing that the fearful memory was incorrectly associated with a safe place 6 . Work from other groups has shown that a similar technique can be used to tag and then block a given memory 7,8 .…”

Section: In Search Of the Engrammentioning

confidence: 99%

How to see a memory

Shen¹

2018

Nature

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Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval

Cited by 339 publications

References 31 publications

Memory Retrieval in Mice and Men

Memory Retrieval in Mice and Men

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

How to see a memory

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