Cortical Thickness Reduction of Normal Appearing Cortex in Patients with Polymicrogyria

Oliveira, Pedro Paulo de MagalhÃ£es; Valente, Kette D.; Shergill, Sukhwinder S.; Leite, Cláudia da Costa; Amaro, Edson

doi:10.1111/j.1552-6569.2009.00372.x

Cited by 12 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FreeSurfer is constantly being improved and extended, with our most recent release including tools for accurate cross-modal intra-subject registration (Greve and Fischl, 2009), combined volume and surface cross-subject registration (Postelnicu et al, 2009b), probabilistic estimation of cytoarchitectonic boundaries (Fischl et al, 2008), automated tractography (Yendiki et al, 2009), and longitudinal analysis (Reuter and Fischl, 2011; Reuter et al, 2010). It has been used to improve our understanding of an array of neurological disorders (Becker et al, 2008; Desikan et al, 2010a,b; Dickerson et al, 2009; Gold et al, 2005; Kuperberg et al, 2003; Manoach et al, 2007; Milad et al, 2005; Oliveira et al, 2010; Rauch et al, 2005; Rosas et al, 2002,2005,2006,2010; Sabuncu et al, 2011; Sailer et al, 2003; Stufflebeam et al, 2011), the genetic basis of neuroanatomical variability and change (Kremen et al, 2010; Panizzon et al, 2009), as well as healthy development (Isaacs et al, 2008; Martinussen et al, 2005) and aging (Fjell et al, 2005,2006; Salat et al, 2004,2005a,2005b,2009; Walhovd et al, 2004,2005a, 2005b, 2006). …”

Section: Resultsmentioning

confidence: 99%

FreeSurfer

2012

View full text Add to dashboard Cite

FreeSurfer is a suite of tools for the analysis of neuroimaging data that provides an array of algorithms to quantify the functional, connectional and structural properties of the human brain. It has evolved from a package primarily aimed at generating surface representations of the cerebral cortex into one that automatically creates models of most macroscopically visible structures in the human brain given any reasonable T1-weighted input image. It is freely available, runs on a wide variety of hardware and software platforms, and is open source.

show abstract

Section: Resultsmentioning

confidence: 99%

FreeSurfer

2012

View full text Add to dashboard Cite

show abstract

“…In localized form, the remaining cortical gray matter may be abnormal (28). The 4 patients with polymicrogyria in our study were of unilateral frontoparietal pattern and were not associated with other cortical abnormality.…”

Section: Discussionmentioning

confidence: 72%

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Alam-Eldeen

Hasan

2015

The Egyptian Journal of Radiology and Nuclear Medicine

View full text Add to dashboard Cite

Objective: Analysis of the role of CT and MRI in evaluation of pediatric epilepsy and their diagnostic utility to detect various pathologic entities at one center. Patients and methods: From April 2012 to April 2014, 181 children with epilepsy were underwent standardized CT and or MRI in the Department of Diagnostic Radiology at Sohag University Hospitals. We retrospectively analyzed whether lesions were detected and whether were precisely characterized by CT and or MRI. Results: Of the 181 patients included in the study, abnormalities were detected in 132 patients (73%) while normal brain images were found in 49 patients (27%). Of the 74 patients had CT only, abnormalities were detected in 73% while 27% were normal. Of the 89 patients underwent MRI only, abnormalities were detected in 74% while 26% were normal. Of the 18 patients underwent CT and MRI, abnormalities were detected in 67% while 33% were normal. Conclusion: Seizure disorders are among the most frequent neurologic problems that occur in childhood. MRI is the technique of choice and is superior to CT in identifying underlying cause. However, CT can serve as a screening modality and MRI would be performed to define abnormalities found on CT or in negative CT studies.

show abstract

“…Group analysis or individual patient discrimination with a different control set using a larger number of subjects may be useful to reduce false positives. However, to date, this is the largest PMG population studied with quantitative analysis as previous quantitative imaging studies were primarily case studies based on a small number of patients due to limitation of image acquisition for patients and the lack of the use of advanced image analysis techniques (Munakata et al 2006;Trivedi et al 2006;Oliveira et al 2009;Saporta et al 2011). Our study is based on the new automated method for quantitative image analysis with a relatively larger set of patients when compared with these prior studies.…”

Section: Discussionmentioning

confidence: 99%

“…The high frequency of small gyri in PMG was represented as abnormal shape in the reconstructed surface. The same surface reconstruction method was used for the cortical thickness analysis of patients with PMG in a previous study (Oliveira et al 2009).…”

Section: Image Processingmentioning

confidence: 99%

Quantification and Discrimination of Abnormal Sulcal Patterns in Polymicrogyria

Im¹,

Pienaar²,

Paldino³

et al. 2012

Cerebral Cortex

View full text Add to dashboard Cite

Polymicrogyria (PMG) is a malformation of cortical development characterized by an irregular gyral pattern and its diagnosis and severity have been qualitatively judged by visual inspection of imaging features. We aimed to provide a quantitative description of abnormal sulcal patterns for individual PMG brains using our sulcal graph-based analysis and examined the association with language impairment. The sulcal graphs were constructed from magnetic resonance images in 26 typical developing and 18 PMG subjects and the similarity between sulcal graphs was computed by using their geometric and topological features. The similarities between typical and PMG groups were significantly lower than the similarities measured within the typical group. Furthermore, more lobar regions were determined to be abnormal in most patients when compared with the visual diagnosis of PMG involvement, suggesting that PMG may have more global effects on cortical folding than previously expected. Among the PMG, the group with intact language development showed sulcal patterns more closely matched with the typical than the impaired group in the left parietal lobe. Our approach shows the potential to provide a quantitative means for detecting the severity and extent of involvement of cortical malformation and a greater understanding of genotype-phenotype and clinical-imaging features correlations.

show abstract

Cortical Thickness Reduction of Normal Appearing Cortex in Patients with Polymicrogyria

Cited by 12 publications

References 34 publications

FreeSurfer

FreeSurfer

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Quantification and Discrimination of Abnormal Sulcal Patterns in Polymicrogyria

Contact Info

Product

Resources

About