Cortical tremor

Ito, Akio; Kakigi, Ryusuke; Funai, N.; Neshige, Ryuji; Kuroda, Yasuhiro; Shibasaki, Hiroshi

doi:10.1212/wnl.40.10.1561

Cited by 212 publications

(188 citation statements)

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“…Our patients developed an irregular tremor of the hands secondary to parietal cortical lesions, and these clinical features are similar to the features of cortical tremor originally described by Ikeda et al [7] as a postural and action tremor with a frequency of more than 8 Hz. It was reported as a variant of cortical reflex myoclonus in association with EEG abnormalities, seizure, abnormal SEPs and long latency EMG responses [8,9,10].…”

Section: Discussionsupporting

confidence: 89%

“…It was reported as a variant of cortical reflex myoclonus in association with EEG abnormalities, seizure, abnormal SEPs and long latency EMG responses [8,9,10]. In the cases of cortical tremor, the neuroimagings of the patients were reported normal, and specific EMG and EEG abnormalities were demonstrated [7,8,9,10]. However, both of our patients had parietal cortical lesions contralateral to the tremor.…”

Section: Discussionmentioning

confidence: 58%

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Two Patients with Tremor Caused by Cortical Lesions

Balcı¹,

Utku²,

Çobanoğlu

2006

Eur Neurol

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Myoclonic tremor due to cortical lesions is a rare condition and must be distinguished from other causes of tremor. This is because the treatment strategies of tremor may differ due to the various etiologies. We present here two cases with myoclonic tremor caused by parietal cortical lesions showing tremulous finger movement provoked by action and posture. Clinical and electrophysiological features of the patients were reported and compared with the features of the patients with cortical tremor in association with cortical reflex myoclonus. Both of our patients responded well to anticonvulsants such as valproate and clonazepam. In patients with acute postural tremor, cortical lesions such as mass occupying lesions, ischemic lesions and arteriovenous malformations should be taken into consideration.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 58%

Two Patients with Tremor Caused by Cortical Lesions

Balcı¹,

Utku²,

Çobanoğlu

2006

Eur Neurol

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“…1,2 Historically, various names have been given to the syndrome that show cortical myoclonic tremor and epilepsy: hereditary tremor with epileptiform seizures, 3 heredofamilial tremor and epilepsy, 4 cortical tremor, 5 familial essential myoclonus and epilepsy, 6 BAFME, 1 familial adult myoclonic epilepsy (FAME), 7 familial benign myoclonus epilepsy of adult onset, 8 familial cortical tremor with epilepsy, 9 autosomal dominant cortical myoclonus and epilepsy 10 and familial cortical myoclonic tremor with epilepsy (FCMTE). 11 Previous genetic studies, including our earlier report, 2 identified three different chromosomal loci, 8q 2,12 (BAFME, FCMTE1), 2p 10,13,14 (FCMTE2) and 5p 15 (FCMTE3) in Japanese, Italian and French pedigrees, respectively.…”

Section: Introductionmentioning

confidence: 99%

Remapping and mutation analysis of benign adult familial myoclonic epilepsy in a Japanese pedigree

et al. 2011

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Benign adult familial myoclonic epilepsy (BAFME), alternatively named familial adult myoclonic epilepsy 1/familial cortical myoclonic tremor with epilepsy 1 (FAME1/FCMTE1), is a hereditary epileptic syndrome characterized by autosomal dominant inheritance, adult-onset tremulous hand movement, myoclonus, infrequent epileptic seizure and non-progressive course without cerebellar ataxia and dementia. We previously reported evidence for linkage of BAFME to the region between D8S1784 and D8S1694 on chromosome 8q. Subsequently, other research groups reported mapping of the same clinical syndrome to different chromosomal loci, 2p and 5p, in Italian (FAME2/FCMTE2) and French (FAME3/FCMTE3) families, respectively. In this study, we performed a genome-wide linkage analysis using 10K single-nucleotide polymorphism arrays and additional microsatellite markers to reconfirm the BAFME-linked region. The BAFME-linked region was mapped to 7.16 Mb spanned by rs1898287 and rs2891799 on chromosomes 8q23.3-8q24.13 with a maximum two-point logarithm of odds score of 6.0 for the marker rs1021897. Sequence analysis and copy-number variant analysis of all 38 genes localized in the candidate region were performed, but no pathogenic mutation was identified. We conclude that the etiology of BAFME remains to be solved, and further genetic studies, which may require analysis in non-coding regions of a gene, introns or intergenic spacer regions, are necessary to reveal its unknown mutations.

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“…2 BAFME was first reported in 1990 in the Japanese population. 3 Until now about 50 Japanese, 10 European families, and a French family were reported. 4 Previous studies revealed that BAFME was mapped to three chromosomal regions on chromosome 8, 5,6 chromosome 2, 7,8 and chromosome 5 4 in the Japanese, European and French populations, respectively.…”

Section: Introductionmentioning

confidence: 99%

A newly identified locus for benign adult familial myoclonic epilepsy on chromosome 3q26.32-3q28

et al. 2012

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Benign Adult Familial Myoclonic Epilepsy (BAFME) is an autosomal dominant disorder characterized by adult-onset cortical tremor or action myoclonus predominantly in the upper limbs, and generalized seizures. We investigated a Thai BAFME family. Clinical and electrophysiological studies revealed that 13 were affected with BAFME. There were a total of 24 individuals studied. Genetic analysis by genome-wide linkage study (GWLS) was performed using 400 microsatellite markers and excluded linkage of the previous BAFME loci, 8q23.3-q24.1, and 2p11.1-q12.2. GWLS showed that the disease-associated region in our Thai family was linked to a newly identified locus on chromosome 3q26.32-3q28. This locus represents the fourth chromosomal region for BAFME.

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Cortical tremor

Cited by 212 publications

References 0 publications

Two Patients with Tremor Caused by Cortical Lesions

Two Patients with Tremor Caused by Cortical Lesions

Remapping and mutation analysis of benign adult familial myoclonic epilepsy in a Japanese pedigree

A newly identified locus for benign adult familial myoclonic epilepsy on chromosome 3q26.32-3q28

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