Cortical Volume Reduction in Schizophrenia Using Mri.

Harvey, Ian; Ma, Ron; Duboulay, G; Wicks, David; Sw, Lewis; Feinstein, Anthony; Rm, Murray

doi:10.1097/00002826-199201001-00065

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, magnetic resonance imaging (MRI) studies have shown reduced whole brain volume and cortical grey matter 5 , and reduced volume of temporal lobe structures, particularly the hippocampus 6 . Neuroimaging techniques have been used to determine whether such structural brain abnormalities are genetically transmitted, and to identify those abnormalities that could serve as biological markers for the transmission of the genotype.…”

Section: Are Structural Brain Abnormalities Genetically Transmitted?mentioning

confidence: 99%

Imaging as a tool in exploring the neurodevelopment and genetics of schizophrenia

Frangou

Murray

1996

British Medical Bulletin

View full text Add to dashboard Cite

Neuroimaging has enabled us to address questions about the timing and origin of brain abnormalities in schizophrenia. First episode and longitudinal computed tomography (CT) and magnetic resonance imaging (MRI) studies of schizophrenic patients have shown that the brain abnormalities are present at onset of psychosis and are non-progressive. Such findings support the idea that schizophrenia is a developmental rather than a degenerative condition. Furthermore, the presence of ventriculomegaly and diminished hemispheric asymmetry in familial schizophrenics and in those of their relatives who appear to be transmitting the disorder, implies involvement of the genes controlling neurodevelopment. However, genetic factors do not fully account for the development of schizophrenia; early environmental insults such as obstetric complications are also important and may interact with genetic predisposition. Brain development continues postnatally and profound maturational events also occur in adolescence and early adulthood. Magnetic resonance spectroscopy (MRS) studies allow the investigation of the developmental biochemistry of the living brain and are being used to explore the role of maturational brain events in determining the onset of psychosis. Neuroimaging methods allow for the safe in vivo study of brain development, structure and function, and provide the means to investigate hypotheses regarding the aetiology and pathophysiology of schizophrenia. In this article, we review neuroimaging studies of schizophrenia, and focus particularly on findings that provide insights into the genetic and neurodevelopmental origins of the disorder.

show abstract

Section: Are Structural Brain Abnormalities Genetically Transmitted?mentioning

confidence: 99%