Corticofugal Modulation and Plasticity for Auditory Signal Processing

Suga, Nobuo

doi:10.1007/978-1-4419-0074-6_24

Cited by 2 publications

(1 citation statement)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these lower-level representations do exhibit longer-term plasticity that reflects developmental changes, as well as learning and experience [7]. Given the extended timescales of these changes, most models have not attempted to capture the dynamics but rather the end results of these slow changes [8,9].…”

Section: Peripheral and Early Auditory Processingmentioning

confidence: 99%

Adaptive auditory computations

Shamma

Fritz

2014

Current Opinion in Neurobiology

View full text Add to dashboard Cite

The auditory system analyses acoustic signals, extracting their perceptual attributes, and exploiting them to navigate complex auditory environments. While many of the basic transformations that give rise to the early auditory representations are well studied and understood, little is known about the latter cognitive functions that bind, organize, and give meaning to them. They include the ability to attend to, segregate, and track one of many sound sources, to learn its identity, commit it to memory, robustly recognize it, and utilize it to make decisions. This review hints at the profound adaptive influences and contextual effects induced by cognitive functions during these behaviors, and the need for robust tractable mathematical models to understand them.

show abstract

Section: Peripheral and Early Auditory Processingmentioning

confidence: 99%

Adaptive auditory computations

Shamma

Fritz

2014

Current Opinion in Neurobiology

View full text Add to dashboard Cite

show abstract

Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

et al. 2015

View full text Add to dashboard Cite

Objective The corticofugal system can alter coding along the ascending sensory pathway. Within the auditory system, electrical stimulation of the auditory cortex (AC) paired with a pure tone can cause egocentric shifts in the tuning of auditory neurons, making them more sensitive to the pure tone frequency. Since tinnitus has been linked with hyperactivity across auditory neurons, we sought to develop a new neuromodulation approach that could suppress a wide range of neurons rather than enhance specific frequency-tuned neurons. Approach We performed experiments in the guinea pig to assess the effects of cortical stimulation paired with broadband noise (PN-Stim) on ascending auditory activity within the central nucleus of the inferior colliculus (CNIC), a widely studied region for AC stimulation paradigms. Main results All eight stimulated AC regions induced extensive suppression of activity across the CNIC that was not possible with noise stimulation alone. This suppression built up over time and remained after the PN-Stim paradigm. Significance We propose that the corticofugal system is designed to decrease the brain’s input gain to irrelevant stimuli and PN-Stim is able to artificially amplify this effect to suppress neural firing across the auditory system. The PN-Stim concept may have potential for treating tinnitus and other neurological disorders.

show abstract

Corticofugal Modulation and Plasticity for Auditory Signal Processing

Cited by 2 publications

References 151 publications

Adaptive auditory computations

Adaptive auditory computations

Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

Contact Info

Product

Resources

About