Corticosteroid binding in human artery.

Sasano, Hironobu; Watanabe, Norimiohi; Sasano, Nobuaki

doi:10.1620/tjem.150.117

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of MR in human vasculature was first reported by Sasano et al, in 1986(Sasano et al 1986) and subsequently reported to be present not only in endothelial but also in smooth muscle cells of human vasculature (Koenig and Jaffe 2014;Nakamura et al 2006;Rizzoni et al 1996). Vascular structural remodeling in small resistance medium sized arteries was also reported in the patients with primary aldosteronism compared to essential hypertensive patients, which indicated that MR in smooth muscle cells could directly mediate the remodeling process of the vessels (Rizzoni et al 1996).…”

Section: Aldosterone Actions On Vascular Smooth Muscle Cells and Their Significance In Vasculopathymentioning

confidence: 85%

Pathology of Aldosterone Biosynthesis and its Action

Gao

Yamazaki

Tezuka

et al. 2021

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

Aldosterone plays pivotal roles in renin-angiotensin-aldosterone system in order to maintain the equilibrium of liquid volume and electrolyte metabolism. Aldosterone action is mediated by both mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Its excessive actions directly induced tissue injuries in its target organs such as myocardial and vascular fibrosis in addition to chronic kidney diseases. Excessive aldosterone actions were also reported to be involved in unbalanced electrolyte metabolism in inflammatory bowel disease and development of pulmonary diseases. Hyperaldosteronism is tentatively classified into primary and secondary types. Primary aldosteronism is more frequent and has been well known to result in secondary hypertension with subsequent cardiovascular damages. Primary aldosteronism is also further classified into distinctive subtypes and among those, aldosterone-producing adenoma is the most frequent one accounting for the great majority of unilateral primary aldosteronism cases. In bilateral hyperaldosteronism, aldosterone-producing diffuse hyperplasia and aldosteroneproducing micronodules or nodules are the major subtypes. All these aldosterone-producing lesions were reported to harbor somatic mutations including KCNJ5, CACNA1D, ATP1A1 and ATP2B3, which were all related to excessive aldosterone production. Among those mutations above, somatic mutation of KCNJ5 is the most frequent in aldosterone-producing adenoma and mostly composed of clear cells harboring abundant aldosterone synthase expression. In contrast, CACNA1D-mutated aldosterone-producing micronodules or aldosterone-producing nodules were frequently detected not only in primary aldosteronism patients but also in the zona glomerulosa of normal adrenal glands, which could eventually lead to an autonomous aldosterone production resulting in normotensive or overt primary aldosteronism, but their details have remained unknown.

show abstract

Section: Aldosterone Actions On Vascular Smooth Muscle Cells and Their Significance In Vasculopathymentioning

confidence: 85%

Pathology of Aldosterone Biosynthesis and its Action

Gao

Yamazaki

Tezuka

et al. 2021

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Since the presence of MR was first detected in the vasculature by Sasano et al, in 1986, research on the MR-mediated effects on the vasculature, including vascular smooth muscle cells (VSMC), has been ongoing [ 166 ]. RAAS components, such as ANGII and aldosterone, were frequently reported to induce oxidative stress resulting in vascular damage, such as vascular remodeling and atherosclerosis [ 167 , 168 , 169 ].…”

Section: Adrenocortical Steroids Induce Distant Cellular Senescence In Other Tissuesmentioning

confidence: 99%

Cellular Senescence in Adrenocortical Biology and Its Disorders

Gao

Liu

et al. 2021

Cells

View full text Add to dashboard Cite

Cellular senescence is considered a physiological process along with aging and has recently been reported to be involved in the pathogenesis of many age-related disorders. Cellular senescence was first found in human fibroblasts and gradually explored in many other organs, including endocrine organs. The adrenal cortex is essential for the maintenance of blood volume, carbohydrate metabolism, reaction to stress and the development of sexual characteristics. Recently, the adrenal cortex was reported to harbor some obvious age-dependent features. For instance, the circulating levels of aldosterone and adrenal androgen gradually descend, whereas those of cortisol increase with aging. The detailed mechanisms have remained unknown, but cellular senescence was considered to play an essential role in age-related changes of the adrenal cortex. Recent studies have demonstrated that the senescent phenotype of zona glomerulosa (ZG) acts in association with reduced aldosterone production in both physiological and pathological aldosterone-producing cells, whereas senescent cortical-producing cells seemed not to have a suppressed cortisol-producing ability. In addition, accumulated lipofuscin formation, telomere shortening and cellular atrophy in zona reticularis cells during aging may account for the age-dependent decline in adrenal androgen levels. In adrenocortical disorders, including both aldosterone-producing adenoma (APA) and cortisol-producing adenoma (CPA), different cellular subtypes of tumor cells presented divergent senescent phenotypes, whereby compact cells in both APA and CPA harbored more senescent phenotypes than clear cells. Autonomous cortisol production from CPA reinforced a local cellular senescence that was more severe than that in APA. Adrenocortical carcinoma (ACC) was also reported to harbor oncogene-induced senescence, which compensatorily follows carcinogenesis and tumor progress. Adrenocortical steroids can induce not only a local senescence but also a periphery senescence in many other tissues. Therefore, herein, we systemically review the recent advances related to cellular senescence in adrenocortical biology and its associated disorders.

show abstract

Steroid hormones and the cardiovascular system: Direct actions of estradiol, progesterone, testosterone, gluco- and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissues

Stumpf

1990

Experientia

View full text Add to dashboard Cite

Knowledge of steroid hormone sites of action and related effects in cardiovascular and neural regulatory tissues is reviewed. Evidence for nuclear receptor sites is derived mainly from autoradiographic studies with relatively intact tissues and some biochemical studies with tissue homogenates. In the heart and in the walls of blood vessels, estradiol, dihydrotestosterone, corticosterone, aldosterone, dexamethasone, and soltriol (vitamin D) show nuclear binding. In the brain and spinal cord, neuronal regions associated with cardiovascular regulation contain nuclear receptors in specific patterns for each steroid hormones, including progesterone and soltriol. These data indicate that all steroid hormones exert direct actions on the cardiovascular system at its different levels of organization, thus enabling adjustment to the changing demands during reproduction (gonadal steroids), stress (adrenal steroids), and solar seasons (vitamin D-soltriol).

show abstract

Corticosteroid binding in human artery.

Cited by 3 publications

References 29 publications

Pathology of Aldosterone Biosynthesis and its Action

Pathology of Aldosterone Biosynthesis and its Action

Cellular Senescence in Adrenocortical Biology and Its Disorders

Steroid hormones and the cardiovascular system: Direct actions of estradiol, progesterone, testosterone, gluco- and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissues

Contact Info

Product

Resources

About