Corticosteroid Therapy in Optic Neuropathy Secondary to Nasopharyngeal Carcinoma

Wahab, Zulaikha; Tai, Evelyn Li Min; Hitam, Wan Hazabbah Wan; Teo, Khairy Shamel Sonny

doi:10.7759/cureus.13735

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…The mass effect of orbital invasion could cause dislocation of orbital content and related proptosis [15]. Furthermore, NPC could affect the orbital apex and lead to compressive optic neuropathy and cavernous sinus defect [28,29]. Because the NPC is frequently associated with orbital invasion which can contribute to mass effect and circulation impairment [14], we proposed that the existence of NPC may exaggerate the probability of glaucoma development especially OAG.…”

Section: Discussionmentioning

confidence: 99%

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

Lu¹,

Lin²,

Hsin³

et al. 2023

Int. J. Med. Sci.

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This study aimed to investigate the possible association between nasopharyngeal carcinoma (NPC) and following open angle glaucoma (OAG). A retrospective research applying the National Health Insurance Research Database (NHIRD) of Taiwan was conducted with a follow up period from January 1, 2000 to December 31, 2016. There were 4184 and 16736 participants that selected and categorized into the NPC and non-NPC groups after exclusion. The major outcome of our study was the development of OAG according to diagnostic codes, exam and managements. The Cox proportional hazard regression was employed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of OAG between the two groups. In this study, a numbers of 151 and 513 OAG episodes occurred in the NPC and non-NPC groups and the NPC population showed a significantly higher incidence of OAG compared to the non-NPC population in multivariable analysis (aHR: 1.293, 95% CI: 1.077-1.551, p = 0.0057). Besides, the cumulative probability of OAG was significantly higher in the NPC group than that in the non-NPC population (p = 0.0041). About other risk factor for OAG, age older than 40 years old, diabetes mellitus and persistent steroid usage were related to OAG occurrence (all p < 0.05). In conclusion, the NPC may be an independent risk factor of following OAG development.

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Section: Discussionmentioning

confidence: 99%

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

Lu¹,

Lin²,

Hsin³

et al. 2023

Int. J. Med. Sci.

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“…In severe cases, the proptosis may be associated with eyeball protrusion and restriction of extraocular muscle movement, which case surgery may be necessary [ 19 , 20 ]. Concerning the optic nerve, the mass effect of the NPC contributed to the compressive optic neuropathy and visual impairment [ 21 ]. About the infectious eye disease, the orbital cellulitis referred to both the inflammatory and infectious reaction in the orbit behind the orbital septum [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

Lee

Hsieh

Huang

et al. 2022

Cancers

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The purpose of this study is to investigate the potential correlation between nasopharyngeal carcinoma (NPC) and both infectious keratitis and orbital cellulitis. The retrospective cohort study used the National Health Insurance Research Database (NHIRD) as a data source. A total number of 4184 patients with NPC diagnosis were selected and matched to 16,736 non-NPC patients via the propensity-score matching (PSM). The main outcomes are the development of infectious keratitis and orbital cellulitis according to diagnostic codes and related medications. The Cox proportional hazard regression was adopted to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of outcomes between the two groups. A total of 35 and 19 episodes of orbital cellulitis occurred in the NPC and non-NPC groups and the aHR was significantly higher in the NPC group (aHR: 1.34, 95% CI: 1.23–1.46, p = 0.0024). There were 2185 and 659 events of infectious keratitis in the NPC and non-NPC groups, and the NPC group revealed a significantly higher aHR than non-NPC group (aHR: 1.34, 95% CI: 1.23–1.46, p < 0.0001). Besides, the cumulative probability of infectious keratitis was significantly higher in the NPC group than the non-NPC group (p < 0.0001). The other risk factors of infectious keratitis include age from 20 to 30 years old, allergic respiratory diseases, allergic dermatological diseases, and external eye diseases (all p < 0.0001). In subgroup analyses, both the incidences of infectious keratitis (aHR: 1.33, 95% CI: 1.21–1.47) and orbital cellulitis (aHR: 2.36, 95% CI: 1.27–4.39) were significantly higher than the non-NPC group. The incidence of infectious keratitis was significantly higher in NPC patients without radiotherapy (aHR: 1.40, 95% CI: 1.26–1.55) compared to non-NPC population, while the rate of orbital cellulitis was similar between the NPC patients without radiotherapy (aHR: 0.76, 95% CI: 0.27–2.14) and non-NPC population. In conclusion, the existence of NPC associates with higher incidence of infectious keratitis which increases with NPC period, and the radiotherapy may be account for the higher rate of orbital cellulitis in NPC population.

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“…In certain cases, the growth of NPC-related tissue in the orbital region can lead to a compressive effect and associated optic neuropathy [15]. In such circumstances, visual acuity is severely and irreversibly impaired [21]. Regarding the relationship between NPC and inflammation, interleukin polymorphism was proposed as a risk factor for NPC [22], and inflammation in the sinonasal tract is correlated with subsequent NPC [23].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma and Its Effect on Dry Eye Disease: A Nationwide Cohort Study

Chen

Yang

Chao

et al. 2022

IJERPH

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The aim of the current study was to investigate the relationship between nasopharyngeal carcinoma (NPC) and dry eye disease (DED) using the National Health Insurance Research Database (NHIRD) of Taiwan. A retrospective cohort study was conducted, and patients with an NPC diagnosis were included. Next, one NPC patient was matched to four non-NPC participants via demographic data and systemic comorbidities. In total, 4184 and 16,736 participants were enrolled in the NPC and non-NPC groups, respectively. The primary outcome was the development of DED one year after the diagnosis of NPC. Cox proportional hazard regression was applied to estimate the adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of DED. In this study, 717 and 2225 DED cases were found in the NPC and non-NPC groups, respectively, and the NPC group showed a significantly higher incidence of DED development compared to the non-NPC group (aHR: 1.45, 95% CI: 1.33–1.58, p < 0.0001) in the multivariable analysis. The other covariates that were positively correlated with DED development included age over 40 years, an education level higher than senior high school, hypertension, DM, allergic pulmonary diseases, allergic otolaryngologic diseases, and allergic dermatological diseases (all p < 0.05). In conclusion, the presence of NPC is an independent risk factor for subsequent DED.

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Corticosteroid Therapy in Optic Neuropathy Secondary to Nasopharyngeal Carcinoma

Cited by 6 publications

References 6 publications

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

Nasopharyngeal Carcinoma and Its Effect on Dry Eye Disease: A Nationwide Cohort Study

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