Corticosterone binding to hippocampus: nuclear and cytosol bindingin vitro

McEwen, Bruce S.; Wallach, Gislaine

doi:10.1016/0006-8993(73)90143-1

Cited by 129 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As mentioned above, MR are also present in non-epithelial cells/ tissues such as the hippocampus (McEwen & Wallach 1973), macrophages (Armanini et al 1985a, Lim et al 2007, VSMC, placenta and heart (Pearce & Funder 1988, Lombes et al 1992. In the absence of the aldosterone specificity-conferring enzyme 11bHSD2, MR are overwhelmingly occupied by glucocorticoids.…”

Section: Mrs Macrophages and Diseasementioning

confidence: 97%

Corticosteroid receptors, macrophages and cardiovascular disease

Rickard¹,

Young²

2009

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on both recruited and tissue resident macrophages, a role for the mineralocorticoid aldosterone in these cells is largely undefined. Emerging evidence, however, suggests that MR signalling may promote pro-inflammatory effects. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease.

show abstract

Section: Mrs Macrophages and Diseasementioning

confidence: 97%

Corticosteroid receptors, macrophages and cardiovascular disease

Rickard¹,

Young²

2009

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

show abstract

“…This is in part because it possesses an abundance of glucocorticoid receptors (McEwen & Wallach 1973). Two types reside there: type I or mineralocorticoid receptor, which is occupied at low basal levels of the hormone, and type II or glucocorticoid receptor, which is occupied during stressful times.…”

Section: The Hippocampal Formation and Correlations Withinmentioning

confidence: 99%

Stressful Experience and Learning Across the Lifespan

Shors

2006

Annu. Rev. Psychol.

203

124

View full text Add to dashboard Cite

It is usually assumed that stressful life events interfere with our ability to acquire new information. However, many studies suggest that stressful experience can enhance processes involved in learning. The types of learning that are enhanced after stressful experiences include classical fear and eyeblink conditioning, as well as processes related to learning about threatening stimuli. Stressful life experiences do seem to interfere with processes involved in memory, often expressed as deficits in the retention or retrieval of information that was acquired prior to and was unrelated to the stressful experience. The trends are limited, as are their implications, because most studies examine adult males, yet the effects of stress on learning processes are influenced by age and sex differences. With respect to mechanisms and anatomical substrates, the effects of stress on learning are usually dependent on the action of stress hormones in combination with neuronal activities within the hippocampus, amygdala, the bed nucleus of the stria terminalis, and the prefrontal cortex.

show abstract

“…These effects are generally assumed to be correlated with the presence of intracellular macromolecules ('receptors') which specifi cally bind glucocorticoids [6, 12, 25, 36, 4i, 47], Although autoradiographic experiments using 3H-cortisol have reported the presence of labeled granule cells in rhesus monkey cere bellum [33], a similar finding for the rat cerebellum has not been reported. Biochemical studies suggest that, whereas specific gluco corticoid receptors are present in the adult rat cerebellum, these are more highly concen trated in limbic brain regions [27], Data on the possible presence and nature of gluco corticoid receptors in the newborn rat cere bellum are lacking.…”

Section: Glucocorticoid Action In the Cerebellummentioning

confidence: 99%

The Effects of Neonatal Hydrocortisone on Rat Cerebellar Development

Bohn

Lauder²

1978

Dev Neurosci

View full text Add to dashboard Cite

The development of the cerebellar cortex was studied in rats treated neonatally (days 1–4) with hydrocortisone. Effects on the external granular layer (EGL) and development of the cerebellar laminæ in lobule VIII were determined by quantitative light-microscopic methods. The ''birthdays'' and numbers of various interneurons generated from the EGL were determined autoradiographically in rats injected with ³H-thymidine on days 1,2,5,7,10,15,21 or 24, and sacrificed on day 72. The growth of the EGL and the mitotic index were reduced during the hydrocortisone treatment, but rebounded following termination of the treatment. Nevertheless, the total number of cells produced by the EGL did not recover to control values and the disappearance of the EGL was not prolonged. In treated rats sacrificed at 72 days, the cerebellar foliation pattern in sagittal sections of vermis was reproducibly changed. In lobule VIII, the total area and areas of the molecular layer and internal granular layer were decreased by 14, 17 and 12%, respectively. The total numbers of all postnatally formed interneurons were decreased by this hormonal treatment, but the number of stellate cells in the outer molecular layer was most affected. During the treatment, greater proportions of both granule cells and interneurons in the inner molecular layer (mainly basket cells) completed early final cell divisions. However, ''birthdays'' for the majority of granule cells were delayed probably as a result of increased cell proliferation in the EGL following release from the HCA treatment. Stellate cell birthdays were unaffected. The developmental consequences following this hormonal manipulation are discussed with respect to possible glucocorticoid actions. The implications of these results for normal rat cerebellar development are also considered.

show abstract

Corticosterone binding to hippocampus: nuclear and cytosol bindingin vitro

Cited by 129 publications

References 24 publications

Corticosteroid receptors, macrophages and cardiovascular disease

Corticosteroid receptors, macrophages and cardiovascular disease

Stressful Experience and Learning Across the Lifespan

The Effects of Neonatal Hydrocortisone on Rat Cerebellar Development

Contact Info

Product

Resources

About