Cortisol controlled release by mesoporous silica

López, T.; Ortiz, Emma; Alexander‐Katz, Roberto; Basaldella, Elena Isabel; Bokhimi, Xim

doi:10.1016/j.nano.2008.08.002

Cited by 28 publications

(11 citation statements)

References 33 publications

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“…These results suggest that the structure of KYNA did not change during the impregnation procedure. Since SBA-15 is a silica-based material, having a different structural arrangement; it also has silanol groups that can interact with the guest drug molecules as we and others have previously reported [28,29]. Therefore, the interactions between KYNA and SBA-15 are similar to those showed in Figure 2(b).…”

Section: Resultssupporting

confidence: 61%

Preparation and Characterization of Kynurenic Acid Occluded in Sol‐Gel Silica and SBA‐15 Silica as Release Reservoirs

López

Ortiz

Gómez

et al. 2014

Journal of Nanomaterials

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Kynurenic acid (KYNA) may have important therapeutic effects in neurological disorders; however, its use as a neuroprotective agent is restricted due to its very limited ability to cross the blood brain barrier (BBB). For this reason, we are looking for new alternatives for KYNA to reach the brain; one of them is using drug delivery systems. To obtain KYNA release reservoirs, KYNA molecules were hosted in two different silica materials. The different KYNA-silica materials were characterized by means of several physical techniques. The spectroscopic studies showed that KYNA molecules remained unchanged once hosted in silica materials. The surface area values of KYNA-silica samples were substantially lower than those for pure silica materials due to the addition of the drug. The electronic micrographs showed that the sol-gel KYNA-silica material consisted of aggregates of nanoparticles around 50 nm in size. On the other hand, the typical SBA-15 hexagonal arrangement was observed, even when hosting KYNA molecules. KYNA release profiles, carried out during approximately 300 hours, showed a first stage of fast drug release followed by a slow release phase. The experimental values fitted to the Peppas equation indicate that the release mechanism was controlled by Fickian diffusion.

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Section: Resultssupporting

confidence: 61%

Preparation and Characterization of Kynurenic Acid Occluded in Sol‐Gel Silica and SBA‐15 Silica as Release Reservoirs

López

Ortiz

Gómez

et al. 2014

Journal of Nanomaterials

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“…However, according to IUPAC classification both pore size values fall within the mesopore range. The increment in pores size is due to the insertion of L-DOPA into silica network [24].…”

Section: Resultsmentioning

confidence: 99%

L-DOPA stabilization on sol–gel silica to be used as neurological nanoreservoirs: Structural and spectroscopic studies

et al. 2015

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“…The inevitable interaction between the drug and the silica matrix is a surface phenomenon 5. When the unmodified silica‐based materials are used, the appearance of initial burst release of the drug is quite obvious, and in some cases, an irregular and unexpected pattern of drug release is also observed 5, 11, 34, 35. The silica‐based materials modified by the biopolymers or surfactants showed some degree of control in their initial burst release of the drugs with controllable release pattern in an extended period of time 5, 16, 26, 36–39.…”

Section: Future Perspectivesmentioning

confidence: 99%

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

Chowdhury

2016

ChemBioEng Reviews

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The utilization of the silica-based materials in biomedical applications is evolving at a rapid pace with attentions mostly devoted to the ordered mesoporous silica nanoparticles (MSNs). However, apart from the ordered-MSNs, a range of other silicabased materials have been extensively applied in the controlled release (CR) of drugs, bone treatments, and bone regeneration, but have gained less attention. This article presents an overview on the recent research advancements of the silica-based materials, i.e., silica xerogels, silica microspheres, silica hybrids, silica microcapsule particles, silica ceramics, silica bioactive glasses, and silica beads which are mainly used in CR of drugs, bone disease treatments, and bone regeneration. The in vitro and in vivo biological evaluations on these silica-based materials for antibacterial properties, osteoblast cell activities, osteogenetic performances, cell adhesion and proliferation, bio-mineralization, and material degradation are discussed. The effect of morphology or surface modifications and addition of bone morphogenetic proteins to the silica-based formulations are illustrated.

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Cortisol controlled release by mesoporous silica

Cited by 28 publications

References 33 publications

Preparation and Characterization of Kynurenic Acid Occluded in Sol‐Gel Silica and SBA‐15 Silica as Release Reservoirs

Preparation and Characterization of Kynurenic Acid Occluded in Sol‐Gel Silica and SBA‐15 Silica as Release Reservoirs

L-DOPA stabilization on sol–gel silica to be used as neurological nanoreservoirs: Structural and spectroscopic studies

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

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