The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease 2016
DOI: 10.1007/978-3-319-45950-9_14
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Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action

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Cited by 2 publications
(5 citation statements)
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“…As in the case of the other investigated genes, its mRNA levels were significantly decreased in the visceral adipose tissue of the patients with obesity, which is consistent with the findings of Veilleux et al [23]. The hexose-6-phosphate glucose 1-dehydrogenase causes the conversion of NADP to NADPH, which can be used by 11β-HSD1 in the reaction of converting cortisone to active cortisol [10]. Previous studies have shown that the expression of these two genes and the activity of the enzymes they encode are positively correlated [28].…”
Section: Discussionsupporting
confidence: 90%
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“…As in the case of the other investigated genes, its mRNA levels were significantly decreased in the visceral adipose tissue of the patients with obesity, which is consistent with the findings of Veilleux et al [23]. The hexose-6-phosphate glucose 1-dehydrogenase causes the conversion of NADP to NADPH, which can be used by 11β-HSD1 in the reaction of converting cortisone to active cortisol [10]. Previous studies have shown that the expression of these two genes and the activity of the enzymes they encode are positively correlated [28].…”
Section: Discussionsupporting
confidence: 90%
“…Since genes encoding enzymes critical for cortisol synthesis and action are expressed in adipocytes (Figure 1) one can assume that obesity-related adipose tissue dysfunction may affect the local and systemic pool of this glucocorticoid [8]. The simplified pathway of glucocorticoid receptor signaling and the action of enzyme involved in glucocorticoid metabolism in adipocytes, based on [9][10][11]. In the absence o glucocorticoid, the glucocorticoid receptor (GR) is located in the cytoplasm and forms a complex with chaperones (hsp90, p23, hsp70) as well as immunophillins (FKBP51, FKBP52).…”
Section: Introductionmentioning
confidence: 99%
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“…MG(18:1(9Z)/0:0/0:0) had positive correlations with prothrombin time (PT) and the level of Ca and negative correlations with red cell distribution width (RDW) and white blood cell (WBC), suggesting that a high level of MG(18:1(9Z)/0:0/0:0) may disrupt blood cell homeostasis and cause an adverse effect on COVID-19. Tetrahydrodeoxycortisol (THS) is derived from cortisol metabolism as a regulator of glucocorticoid action in liver and kidney [37] , [38] . For this reason, a negative relationship between THS and alanine aminotransferase (ALT) indicates that glucocorticoid might be an effective drug for improving the liver and kidney functions in COVID-19 patients.…”
Section: Resultsmentioning
confidence: 99%