Corylin ameliorates chronic ulcerative colitis via regulating the gut–brain axis and promoting 5-hydroxytryptophan production in the colon

Wang, Zhao-Jing; Chen, Lihua; Xu, Jing; Xu, Qing-Xia; Xu, Wei; Yang, Xiu‐Wei

doi:10.1016/j.phymed.2023.154651

Cited by 25 publications

(10 citation statements)

References 54 publications

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“…Another study found that when the intestinal vascular barrier is damaged, intestinal bacteria are more likely to spread to the liver, promoting the formation of a pre-metastatic niche for “colon-liver” metastasis, thereby promoting the recruitment of metastatic cells ( Bertocchi et al, 2021 ). As mentioned earlier, Sishen Pills ( Zhang et al, 2021c ), schisandrin B ( Li et al, 2019b ), schisandrin C ( Kim et al, 2022 ), and corylin ( Wang et al, 2023f ) can regulate the secretion of intestinal epithelial tight junction proteins and mucin, repair damaged intestinal mucosal barriers and inhibit the progression of IBD ( Figure 3D ).…”

Section: Discussion On the Common Molecular Mechanism Of Sishen Pill ...mentioning

confidence: 82%

“…Also, the genotoxin produced by Escherichia-Shigella can penetrate the colon cell membrane and migrate to the nucleus, causing DNA double strand breaks, cell cycle arrest, chromosomal aberrations, intestinal epithelial damage, and eventually leading to cancer ( Fan et al, 2021b ). The above studies show that Sishen Pill can increase the relative abundance of AKK in the intestine ( Chen et al, 2020b ; Ge et al, 2022 ; Jin et al, 2023 ) and its effective metabolites, evodiamine, and corylin, leading to significant inhibition of Escherichia-Shigella the proliferation ( Zhu et al, 2021 ; Wang et al, 2023f ) thereby exerting anti-inflammatory and anticancer pharmacological activities.…”

Section: Discussion On the Common Molecular Mechanism Of Sishen Pill ...mentioning

confidence: 99%

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Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Zhang,

Cheng,

Jian

et al. 2024

Front. Pharmacol.

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The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and Schisandra Chinensis. Modern research has confirmed that Sishen Pill and its active secondary metabolites, such as psoralen, myristicin, evodiamine, and schisandrin, can improve intestinal inflammation and exert antitumor pharmacological effects. Common mechanisms in treating IBD and colon cancer mainly include regulating inflammation-related signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat protein domain-related protein 3, and wingless-type MMTV integration site family; NF-E2-related factor 2 and hypoxia-inducible factor 1α to inhibit oxidative stress; mitochondrial autophagy and endoplasmic reticulum stress; intestinal immune cell differentiation and function through the Janus kinase/signal transducer and activator of transcription pathway; and improving the gut microbiota and intestinal barrier. Overall, existing evidence suggests the potential of the Sishen pill to improve IBD and suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies and research on the safety of these clinical applications are urgently required.

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Section: Discussion On the Common Molecular Mechanism Of Sishen Pill ...mentioning

confidence: 82%

Section: Discussion On the Common Molecular Mechanism Of Sishen Pill ...mentioning

confidence: 99%

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Zhang,

Cheng,

Jian

et al. 2024

Front. Pharmacol.

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“…In this send, it is possible that altered histamine metabolism might influenced the abundance of some, if not all, bacteria identified in our study. Intriguingly, the levels of these bacteria were inextricably linked to a plethora of bioclinical implications, including autistic symptom ( Ye et al, 2021 ; Deng et al, 2022b ), intestinal inflammation ( Gu et al, 2022 ), gut neurotransmitter production ( Deng et al, 2022b ; Wang Z. J. et al, 2023 ), and bile acid metabolism ( Jian et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication

Fu,

Yang,

Jiang

et al. 2024

Front. Microbiol.

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The gut-brain axis is evident in modulating neuropsychiatric diseases including autism spectrum disorder (ASD). Chromosomal 16p11.2 microduplication 16p11.2dp/+ is among the most prevalent genetic copy number variations (CNV) linked with ASD. However, the implications of gut microbiota status underlying the development of ASD-like impairments induced by 16p11.2dp/+ remains unclear. To address this, we initially investigated a mouse model of 16p11.2dp/+, which exhibits social novelty deficit and repetitive behavior characteristic of ASD. Subsequently, we conducted a comparative analysis of the gut microbial community and metabolomic profiles between 16p11.2dp/+ and their wild-type counterparts using 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC/MS). Our microbiota analysis revealed structural dysbiosis in 16p11.2dp/+ mice, characterized by reduced biodiversity and alterations in species abundance, as indicated by α/β-diversity analysis. Specifically, we observed reduced relative abundances of Faecalibaculum and Romboutsia, accompanied by an increase in Turicibacter and Prevotellaceae UCG_001 in 16p11.2dp/+ group. Metabolomic analysis identified 19 significantly altered metabolites and unveiled enriched amino acid metabolism pathways. Notably, a disruption in the predominantly histamine-centered neurotransmitter network was observed in 16p11.2dp/+ mice. Collectively, our findings delineate potential alterations and correlations among the gut microbiota and microbial neurotransmitters in 16p11.2dp/+ mice, providing new insights into the pathogenesis of and treatment for 16p11.2 CNV-associated ASD.

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“…One of the primary mechanisms by which the gut microbiota maintains health is through its metabolites [ 42 ]. Gut microbiota-derived tryptophan metabolites, such as indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde, were proven to regulate gut barrier function and the immune response by activating the aryl hydrocarbon receptor [ 43 , 44 ]. Bile acids (BAs) are potent metabolic and immune signaling molecules, and their composition depends largely on the gut bacterial species [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis

Jia,

Li,

Wang

et al. 2024

IJMS

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Despite Bacillus species having been extensively utilized in the food industry and biocontrol as part of probiotic preparations, limited knowledge exists regarding their impact on intestinal disorders. In this study, we investigated the effect of Bacillus licheniformis ZW3 (ZW3), a potential probiotic isolated from camel feces, on dextran sulfate sodium (DSS)-induced colitis. The results showed ZW3 partially mitigated body weight loss, disease activity index (DAI), colon shortening, and suppressed immune response in colitis mice, as evidenced by the reduction in the levels of the inflammatory markers IL-1β, TNF-α, and IL-6 (p < 0.05). ZW3 was found to ameliorate DSS-induced dysfunction of the colonic barrier by enhancing mucin 2 (MUC2), zonula occluden-1 (ZO-1), and occludin. Furthermore, enriched beneficial bacteria Lachnospiraceae_NK4A136_group and decreased harmful bacteria Escherichia-Shigella revealed that ZW3 improved the imbalanced gut microbiota. Abnormally elevated uric acid levels in colitis were further normalized upon ZW3 supplementation. Overall, this study emphasized the protective effects of ZW3 in colitis mice as well as some potential applications in the management of inflammation-related diseases.

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Corylin ameliorates chronic ulcerative colitis via regulating the gut–brain axis and promoting 5-hydroxytryptophan production in the colon

Cited by 25 publications

References 54 publications

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication

Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis

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