Cost-Effective Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) and Based on Imprinted Receptors for Fluvoxamine Assessment

Hashem, Heba M.; Hassan, Saad S. M.; Kamel, Ayman H.; Amr, Abd El‐Galil E.; Abdel‐Bary, E. M.

doi:10.3390/polym12030673

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…The presence of a prominent peak at around 1290 cm À 1 provides evidence for the existence of a sulfonic functional group in MAF grafted on GO [56] (Figure 1c). A strong peak at 1327 cm À 1 is ascribed to the CÀ F stretching of FLU introduced on GO [57] (Figure 1d).…”

Section: Ft-ir Analysis and Raman Spectroscopymentioning

confidence: 99%

Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide

Ghorbani,

Tarlani,

Taghvaei‐Ganjali

et al. 2024

ChemistrySelect

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With the aim of obtaining new composites from graphene oxide for a new biological application, it urged us to select some amine containing molecules namely purpald, mafenide acetate and fluvoxamine for grafting that was resulted to the formation of purpald‐grafted graphene oxide, mafenide‐grafted graphene oxide and fluvoxamine‐grafted graphene oxide, respectively. These novel nanocomposites were evaluated by X‐ray photoelectron spectroscopy, Transmission electron microscopy, Field emission scanning electron microscopy,Dynamic light scattering, Zeta potential, X‐ray diffraction, Thermogravimetric analysis, Raman, and Fourier‐transform infrared. The findings demonstrated that the grafting was done satisfactorily. X‐ray photoelectron spectroscopy analysis revealed that the peaks seen at 286.07, 285.79, and 285.49 eV corresponded to the formation of carbon‐nitrogen bonds between the amine groups of purpald, mafenide acetate, and fluvoxamine, respectively, and the functionalized oxygen groups present on the surface of graphene oxide. In this study, three nanocomposites were subjected to practical testing in close proximity to human breast cancer cells. After a period of 24 hours, it was shown that purpald‐grafted graphene oxide demonstrated more cellular toxicity compared to the other nanocomposites.

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Section: Ft-ir Analysis and Raman Spectroscopymentioning

confidence: 99%

Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide

Ghorbani,

Tarlani,

Taghvaei‐Ganjali

et al. 2024

ChemistrySelect

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“…The ion-sensing membranes were casted as reported earlier [34,35]. 2 mg portion of the electro-active sensing material (TDMAC or Aliquate), 44 mg of DOP plasticizer, 44 mg of PVC-COOH as a polymeric matrix were mixed and dissolved/homogenized in ~2 mL THF with stirring/vortex-shaking.…”

Section: Sensor Constructionmentioning

confidence: 99%

Screen‐printed electrochemical sensors for label‐free potentiometric and impedimetric detection of human serum albumin

et al. 2023

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Herein, two electrochemical methods based on potentiometric and impedimetric transductions were presented for albumin targeting, employing screen‐printed platforms (SPEs) to make easy and cost‐effective sensors with good detection merits. The SPEs incorporated ion‐to‐electron multi‐walled carbon nanotubes (MWCNTs) transducer. Sensors were constructed using either tridodecyl methyl‐ammonium chloride (TDMACl) (sensor I) or aliquate 336S (sensor II) in plasticized polymeric matrices of carboxylated poly (vinyl chloride) (PVC‐COOH). Analytical performances of the sensors were evaluated using the above‐mentioned electrochemical techniques. For potentiometric assay, constructed sensors responded to albumin with −81.7 ± 1.7 (r2 = 0.9986) and −146.2 ± 2.3 mV/decade (r2 = 0.9991) slopes over the linearity range 1.5 μM–1.5 mM with 0.8 and 1.0 μM detection limits for respective TDMAC‐ and aliquate‐based sensors. Interference study showed apparent selectivity for both sensors. Impedimetric assays were performed at pH = 7.5 in 10 mM PBS buffer solution with a 0.02 M [Fe(CN)6]−3/−4 redox‐active electrolyte. Sensors achieved detection limits of 4.3 × 10−8 and 1.8 × 10−7 M over the linear ranges of 5.2×10−8–1.0×10−4 M and 1.4×10−6–1.4×10−3 M, with 0.09 ± 0.004 and 0.168 ± 0.009 log Ω/decade slopes for sensors based on TDMAC and aliquate, respectively. These sensors are characterized with simple construction, high sensitivity and selectivity, fast response time, single‐use, and cost‐effectiveness. The methods were successfully applied to albumin assessment in different biological fluids.

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“…The MIP-modified sensor displayed a greater affinity towards fluvoxamine than the NIP sensor. When compared to the HPLC method, the results were satisfactory, revealing recovery values of 97.4–101.9% [ 96 ].…”

Section: Carbon–polymer Composite-based Modification Of Electrode Sur...mentioning

confidence: 99%

Review on Surface-Modified Electrodes for the Enhanced Electrochemical Detection of Selective Serotonin Reuptake Inhibitors (SSRIs)

et al. 2023

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Selective serotonin re-uptake inhibitors (SSRIs) are one of the most commonly prescribed classes of antidepressants used for the treatment of moderate to severe depressive disorder, personality disorders and various phobias. This class of antidepressants was created with improved margins of safety. However, genetic polymorphism may be responsible for the high variability in patients’ responses to treatment, ranging from failure to delayed therapeutic responses to severe adverse effects of treatment. It is crucial that the appropriate amount of SSRI drugs is administered to ensure the optimum therapeutic efficacy and intervention to minimise severe and toxic effects in patients, which may be the result of accidental and deliberate cases of poisoning. Determining SSRI concentration in human fluids and the environment with high sensitivity, specificity and reproducibility, and at a low cost and real-time monitoring, is imperative. Electrochemical sensors with advanced functional materials have drawn the attention of researchers as a result of these advantages over conventional techniques. This review article aims to present functional materials such as polymers, carbon nanomaterials, metal nanomaterials as well as composites for surface modification of electrodes for sensitive detection and quantification of SSRIs, including fluoxetine, citalopram, paroxetine, fluvoxamine and sertraline. Sensor fabrication, sensor/analyte interactions, design rationale and properties of functional material and the electrocatalytic effect of the modified electrode on SSRI detection are discussed.

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Cost-Effective Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) and Based on Imprinted Receptors for Fluvoxamine Assessment

Cited by 8 publications

References 46 publications

Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide

Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide

Screen‐printed electrochemical sensors for label‐free potentiometric and impedimetric detection of human serum albumin

Review on Surface-Modified Electrodes for the Enhanced Electrochemical Detection of Selective Serotonin Reuptake Inhibitors (SSRIs)

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