This paper presents the preliminary results from the 2022 fieldwork of the Palamas Archaeological Project, an ongoing Greek–Swedish collaboration in the region of Karditsa, Thessaly. Working over the course of two separate field seasons, the project team conducted aerial, architectural, fieldwalking, and geophysical surveys at a number of sites within the survey area, including at the important multi-phase fortified settlements at Metamorfosi and Vlochos. Limited excavations were also conducted at the latter site, producing new evidence for the Hellenistic and Early Byzantine phases of the ancient city, including a probable cemetery. The work continues to add to the knowledge of the archaeology of the region, highlighting the long and dynamic history of human habitation in western Thessaly.