Cost-Effectiveness Model of Topical Treatment of Mild to Moderate Psoriasis Vulgaris in Germany

Augustin, Matthias; Peeters, Patrick; Radtke, Marc Alexander; Moehling, Ulrich; Lapp, Christina

doi:10.1159/000106791

Cited by 23 publications

(2 citation statements)

References 68 publications

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“…The formulation was well tolerated with no serious adverse events, a fact that has been well established in the medical literature even after long-term use of the calcipotriol/betamethasone formulation for scalp psoriasis [13]. In addition, cost-effectiveness of the two-compound formulation has been shown to be superior to that of the morning-evening non-fix combination for psoriasis vulgaris [14]. …”

Section: Discussionmentioning

confidence: 99%

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Rigopoulos¹,

Gregoriou²,

Daniel

et al. 2009

Dermatology

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Background: Treatment of nail psoriasis remains a challenge. Objective: To evaluate the efficacy of a two-compound product of calcipotriol plus betamethasone dipropionate ointment on nail psoriasis in an open-label study. Methods: Twenty-five psoriatic patients with nail involvement and mild cutaneous psoriasis were instructed to apply a calcipotriol-betamethasone valerate ointment formulation once daily for 12 weeks on affected nails. Outcome measures were assessed at baseline and at weeks 4, 8 and 12 using the nail psoriasis severity index (NAPSI). Results: Twenty-two patients having 114 nails involved at baseline with a mean NAPSI of 5.8 ± 1.7 were followed up for 12 weeks. The mean NAPSI at the end of the treatment period was reduced to 1.6 ± 0.6 presenting a 72% improvement. Significant improvement was observed for hyperkeratosis and onycholysis (reduction of mean hyperkeratosis NAPSI from 2.2 ± 0.5 to 0.5 ± 0.1 and mean onycholysis NAPSI from 2.0 ± 0.6 to 0.4 ± 0.2), moderate improvement for oil drops (reduction of mean oil drop NAPSI from 1.2 ± 0.4 to 0.8 ± 0.3) and slight improvement for pitting (reduction of mean pitting NAPSI from 0.8 ± 0.2 to 0.6 ± 0.2). Conclusions: The calcipotriol plus betamethasone dipropionate two-compound ointment, applied once daily for 12 weeks, was shown to improve nail psoriasis.

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Section: Discussionmentioning

confidence: 99%

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Rigopoulos¹,

Gregoriou²,

Daniel

et al. 2009

Dermatology

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“…In these studies, calcipotriol plus betamethasone dipropionate ointment was significantly more effective than either compound used alone [18,19,20,21,22,23,24]. The advantage of using the 2-compound product is further supported by the cost-effectiveness of the treatment [25, 26]. …”

Section: Discussionmentioning

confidence: 99%

Calcipotriol plus Betamethasone Dipropionate Scalp Formulation Is Effective and Well Tolerated in the Treatment of Scalp Psoriasis: A Phase II Study

Buckley

Hoffmann²,

Shapiro

et al. 2008

Dermatology

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Background: There is a need for more effective therapy for scalp psoriasis. Objective: To assess the efficacy and safety of a 2-compound scalp formulation including calcipotriol and betamethasone dipropionate in the treatment of scalp psoriasis. Methods: Patients (n = 218) with scalp psoriasis were randomized to treatment with the 2-compound scalp formulation (n = 108) or betamethasone dipropionate in the same vehicle (n = 110). The treatments were applied once daily on the scalp for up to 8 weeks. Results: The 2-compound scalp formulation showed a significantly higher efficacy than betamethasone dipropionate on the total sign score at the end of treatment (p = 0.042) and after 2 weeks (p = 0.005). Conclusion: The calcipotriol plus betamethasone dipropionate scalp formulation was superior to betamethasone dipropionate in the same vehicle when used once daily for up to 8 weeks in the treatment of scalp psoriasis.

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Dermatologische Versorgungsforschung in Deutschland

Franzke

Augustin²

2011

Hautarzt

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Assessment of benefits and quality of medical healthcare treatment is becoming more and more important. In order to accurately carry out this assessment and to assure a reliable planning of health care, valid data are needed. Health services research is an interdisciplinary field of research, which provides information on disease and health care and to uncover suboptimal and incorrect services. This information can be used to improve the quality of treatment and to increase efficiency. In order to obtain information on the health care for skin and allergic diseases the German Center for Health Services in Dermatology (CVderm) was founded in 2005. It is actively involved in the coordination and conducation of health care, collaborating with other university groups.

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Cost-Effectiveness Model of Topical Treatment of Mild to Moderate Psoriasis Vulgaris in Germany

Cited by 23 publications

References 68 publications

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Calcipotriol plus Betamethasone Dipropionate Scalp Formulation Is Effective and Well Tolerated in the Treatment of Scalp Psoriasis: A Phase II Study

Dermatologische Versorgungsforschung in Deutschland

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