Cost Effectiveness of Pharmacological Management for Osteoarthritis: A Systematic Review

Shi, Jiayu; Fan, Kenan; Yan, Lei; Fan, Zijuan; Li, Fēi; Wang, Guishan; Liu, Haifeng; Liu, Peidong; Yu, Hongmei; Li, Jiao Jiao; Wang, Bin

doi:10.1007/s40258-022-00717-0

Cited by 8 publications

(4 citation statements)

References 96 publications

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“…Our study placed the most emphasis on the incremental cost-effectiveness ratio (ICER) as a primary outcome measure. The ICER is a specific value that can be expressed as the price for each quality-adjusted life-year (QALY) gained [ 43 ]. The QALY assumes that a year of life lived in perfect health is worth 1 QALY [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Vo,

Le,

Chu

et al. 2023

Healthcare

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Osteoarthritis (OA) is a chronic condition that most frequently affects older adults. It is currently the most common disability. The cost of treating an aging population places pressure on the healthcare budget. As a result, it is imperative to evaluate medicines’ cost-effectiveness and, accordingly, their influence on health resource allocation. Our study aims to summarize the cost and outcome of utilizing glucosamine in OA treatment. Databases like Medline, Cochrane, and Scopus were searched as part of the identification process up until April 2023. Our primary inclusion criteria centered on the economic evaluation of glucosamine in OA treatments, providing an incremental cost-effectiveness ratio (ICER). The Quality of Health Economic Studies (QHES) instrument was applied to grade the quality of the studies. Seven qualified studies that discussed the cost-effectiveness of glucosamine with or without other formulations were selected. All of them demonstrated that glucosamine was cost-effective. There was an increase in quality-adjusted life years (QALYs) when incorporating glucosamine in conventional care. Moreover, patented crystalline glucosamine sulfate (pCGS) was more cost-effective than the other formulations of glucosamine (OFG). Overall, utilizing pCGS was more beneficial than using OFG in terms both of cost and quality of life.

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Section: Methodsmentioning

confidence: 99%

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Vo,

Le,

Chu

et al. 2023

Healthcare

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“…Furthermore, a systematic review delved into the cost-effectiveness of pharmacological therapy for managing OA. The review unveiled substantial heterogeneity among studies, with interventions such as NSAIDs, opioid analgesics, symptomatic slow-acting drugs for OA, and intra-articular injections exhibiting varying incremental cost-effectiveness ratios per QALY [ 40 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of Current Management Trends in Medial Compartment Arthritis of the Knee Joint

Kawde,

Pisulkar,

Salwan

et al. 2024

Cureus

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Medial compartment arthritis of the knee joint presents a significant clinical challenge, with diverse management options ranging from nonsurgical interventions to various surgical procedures. This comprehensive review synthesizes current evidence on the management trends in medial compartment arthritis, highlighting both nonsurgical approaches such as physical therapy, pharmacological interventions, and intra-articular injections as well as surgical interventions, including arthroscopic debridement, high tibial osteotomy, and knee arthroplasty. Through a comparative analysis of efficacy, complication rates, and patient outcomes, this review underscores the importance of tailoring treatment strategies to individual patient characteristics and preferences. Furthermore, emerging techniques and technologies promise to advance the field, necessitating ongoing research efforts to refine treatment algorithms and establish standardized guidelines. By adopting a multidisciplinary approach and integrating evidence-based practices, clinicians can optimize the management of medial compartment arthritis and enhance patient care outcomes.

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“…These procedures are very sophisticated and depend on healthy cartilage [ 22 ]. Pharmacological therapies include symptomatic slow-acting drugs (glucosamine and chondroitin sulfate), opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and IA injections of substances such as corticosteroids, blood-derived products, and HA [ 23 ]. Osteoarthritis Research Society International (OARSI) recommends considering side effects while choosing medications for osteoarthritis patients.…”

Section: Intra-articular Administration Of Therapeuticsmentioning

confidence: 99%

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Koland

Vadakkepushpakath

John

et al. 2022

Gels

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The intra-articular administration of conventional drug solutions or dispersions in joint diseases such as osteoarthritis has a relatively short retention time and, therefore, limited therapeutic effect. Thermosensitive polymer solutions that exhibit a sol–gel phase transition near body temperature after injection can prolong drug retention by providing a depot from which the drug release is sustained while relieving inflammation and preventing degradation of the joint complex. Thermosensitive hydrogels have in recent times garnered considerable attention in the intra-articular therapeutics of joint diseases such as osteoarthritis. Among the stimuli-responsive gelling systems, most research has focused on thermosensitive hydrogels. These gels are preferred over other stimuli-sensitive hydrogels since they have well-controlled in situ gelling properties and are also easier to load with drugs. Temperature-sensitive polymers, such as block copolymers or poloxamers, are frequently used to modify their gelation properties, usually in combination with other polymers. They are compatible with most drugs but may pose formulation challenges in terms of their low-response time, highly fragile nature, and low biocompatibility. The stability and biodegradability of implant hydrogels can control the drug release rate and treatment efficacy. This review stresses the application of thermosensitive gels in joint disorders and summarizes recent developments for intra-articular application, including the incorporation of nanoparticles. The hydrogel composition, drug release mechanisms, and the challenges involved in their formulation and storage are also discussed.

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Cost Effectiveness of Pharmacological Management for Osteoarthritis: A Systematic Review

Cited by 8 publications

References 96 publications

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

A Comprehensive Review of Current Management Trends in Medial Compartment Arthritis of the Knee Joint

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

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