Cost-effectiveness of proton therapy in treating base of skull chordoma

Austin, Annabelle M.; Douglass, Michael; Nguyen, Giang T.; Dalfsen, Raymond; Le, Hien; Gorayski, Peter; Tee, Hui; Penniment, Michael; Penfold, Scott

doi:10.1007/s13246-019-00810-0

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Therefore, long-term follow-up in clinical practice is necessary to assess the effect of PBT on decreasing onset of second cancer. SR-3: Cost-effectiveness of proton beam therapy [28][29][30][31][32][33][34][35][36][37][38][39][100][101][102][103][104][105][106] All of the above studies estimated the reduction in adverse events using organ doses calculated based on a radiotherapy plan and a model for the relationship between organ doses and effects. PBT for childhood brain tumor, particularly medulloblastoma, was confirmed to have better cost-effectiveness due to reduced adverse events.…”

Section: General Remarksmentioning

confidence: 99%

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Mizumoto

Fuji

Miyachi

et al. 2021

Cancer Treatment Reviews

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PediatricChildren AYA Guideline events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. To define the outcomes and characteristics of PBT in cancer treatment in pediatric and AYA patients, this document was developed by the Japanese Society for Radiation Oncology (JASTRO) and the Japanese Society of Pediatric Hematology/Oncology (JSPHO).

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Section: General Remarksmentioning

confidence: 99%

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Mizumoto

Fuji

Miyachi

et al. 2021

Cancer Treatment Reviews

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Proton beam therapy for skull base chordomas: a systematic review of tumor control rates and survival rates

Pahwa

Medani

et al. 2022

Neurosurg Rev

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Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024

Saito,

Mizumoto,

Oshiro

et al. 2024

Cancers

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[Objective] The aim of this study was to compare the efficacy of particle beam therapy (PT) with photon radiotherapy (RT) for treatment of skull base chordoma. [Methods] A systematic review was conducted for skull base chordoma treated with PT or photon RT reported from 1990 to 2022. Data were extracted for overall survival (OS) and progression-free survival (PFS), late adverse events, age, gender, gross total resection (GTR) rates, tumor volume, total irradiation dose, and treatment modality. Random-effects meta-regression analysis with the treatment modality as an explanatory variable was performed for each outcome to compare the modalities. [Results] A meta-analysis of 30 selected articles found 3- and 5-year OS rates for PT vs. photon RT or combined photon RT/proton beam therapy (PBT) of 90.8% (95% CI: 87.4–93.3%) vs. 89.5% (95% CI: 83.0–93.6%), p = 0.6543; 80.0% (95% CI: 75.7–83.6%) vs. 89.5% (95% CI: 83.0–93.6%), p = 0.6787. The 5-year PFS rates for PT vs. photon RT or photon RT/PBT were 67.8% (95% CI: 56.5–76.7%) vs. 40.2% (95% CI: 31.6–48.7%), p = 0.0004. A random-effects model revealed that the treatment modality (PT vs. photon RT or photon RT/PBT) was not a significant factor for 3-year OS (p = 0.42) and 5-year OS (p = 0.11), but was a significant factor for 5-year PFS (p < 0.0001). The rates of brain necrosis were 8–50% after PT and 0–4% after photon RT or photon RT/PBT. [Conclusion] This study shows that PT results in higher PFS compared to photon RT for skull base chordoma, but that there is a tendency for a higher incidence of brain necrosis with PT. Publication and analysis of further studies is needed to validate these findings.

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Cost-effectiveness of proton therapy in treating base of skull chordoma

Cited by 3 publications

References 22 publications

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines

Proton beam therapy for skull base chordomas: a systematic review of tumor control rates and survival rates

Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024

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