Cotrifazid – An Agent against Malaria

Freerksen, E; Kanthumkumva, E.W.; Kholowa, A.R.K.

doi:10.1159/000239472

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…A putative prokaryote-like RNA polymerase in P. falciparum has been suggested as one possible target of rifampin (10). A fixed combination of rifampin, co-trimoxazole, and isoniazid was found to be highly effective for the treatment of malaria (9,15). Rifampin was found to be more active after prolonged exposure, in contrast to the results of Divo et al (6).…”

Section: Discussionmentioning

confidence: 97%

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Pradines

Rogier

Fusaı̈

et al. 2001

Antimicrob Agents Chemother

107

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The in vitro activities of cyclines (tetracycline, doxycycline, minocycline, oxytetracycline, and rolitetracycline), macrolides (erythromycin, spiramycin, roxithromycin, and lincomycin), quinolones (norfloxacin and ofloxacin), rifampin, thiamphenicol, tobramycin, metronidazole, vancomycin, phosphomycin, and cephalosporins (cephalexin, cefaclor, cefamandole, cefuroxime, ceftriazone, cefotaxime, and cefoxitin) were evaluated on Plasmodium falciparum clones, using an isotopic, micro-drug susceptibility test. Only tetracyclines, macrolides, quinolones, and rifampin demonstrated in vitro activity against P. falciparum, which increased after a prolonged exposure (96 or 144 h). In the presence of iron (FeCl 3 ), only the activities of tetracyclines and norfloxacin were decreased. Their in vitro activity against intraerythrocytic stages of multidrug-resistant P. falciparum and their efficacy in vivo favor the use of antibiotics as antimalarial drugs. However, due to their slow antimalarial action and to the fact that they act better after prolonged contact, they probably need to be administered in conjunction with a rapidly acting antimalarial drug, such as a short course of chloroquine or quinine.

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Section: Discussionmentioning

confidence: 97%

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Pradines

Rogier

Fusaı̈

et al. 2001

Antimicrob Agents Chemother

107

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“…The reasons for use of CF in the treatment of malaria tropica was based exclusively on empiric data reported in 1995/1996 [5,6]. These investigators reported previously for CF positive therapeutic results in tuberculosis, leprosy and chronic Salmonella sp.…”

Section: Discussionmentioning

confidence: 99%

“…These investigators reported previously for CF positive therapeutic results in tuberculosis, leprosy and chronic Salmonella sp. carriers [6]; they postulated a 'synergism' between CF components [19] and stressed the need for a fixed combination, particularly for low-income countries [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…The fixed combination of rifampicin, cotrimoxazole and isoniazid (CF, Cotrifazid TM ) was reported [5,6] to be effective in the treatment of malaria tropica, even in cases of apparent drug resistance of the P. falciparum to conventional antimalarials. It is the aim of this study to scrutinize these findings from Malawi under the conditions of a hyperendemic Kenyan region.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Malaria tropica with a Fixed Combination of Rifampicin, Co-Trimoxazole and Isoniazid: A Clinical Study

Goerg¹,

Ochola²,

Goerg

1999

Chemotherapy

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The treatment of malaria tropica is becoming difficult because of the increasing drug resistance rates of Plasmodium falciparum against several of the currently available antimalarias. A fixed combination of rifampicin, co-trimoxazole and isoniazid (Cotrifazid^TM, CF) was found to be highly effective for the treatment of malaria tropica. The aim of the present study in Kenya was to scrutinize this finding in a 14-day trial. Patients with malaria tropica were given in an open, double-arm randomized study CF for 5 days, or chloroquine or pyrimethamine/sulphadoxine as the control. Because of an apparently better activity and tolerance of CF, the randomization had to be stopped after the enrollment of 50 patients. A total of 61 patients in both groups (35 of them between 2 months and 6 years of age) were available for final analysis. All 41 patients treated with CF, originally positive in their blood smears, turned negative; in 2 cases blood smear positivity reappeared on day 14. There were 7 failures in the control group, 4 of them a primary one. Four of those failures were turned negative with CF, 2 failed with CF also, and 1 disappeared. The tolerance of CF was excellent even in infants. In our experience, CF is very well suited for the treatment of malaria tropica, also in cases of apparent drug resistance of P. falciparum against other antimalarials, and even in severe cases of the disease.

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“…Medizinisches-diagnostisches Institut, Fatol Arzneimittel GmbH, Schiffweiler, Deutschland A fixed combination of rifampicin (RIF) + isoniazid (INH) + cotrimoxazolc (SXT) (Cotrifazid™) was suggested by Freerkscn et al [1,2] in this journal as a possible alternative for Plasmodium falci parum-provoked malaria. In this connection, a frequently raised ar gument against the use of Cotrifa zid on a broad scale, particularly in high TB prevalence countries, is the assumed possibility of selecting for RIF-rcsistant strains of tubercle bacilli, particularly in regions with possibly high INH drug resistance of Mycobacterium tuberculosis.…”

mentioning

confidence: 99%

Improbability of Selection for RIF Resistance in <i>Mycobacterium tuberculosis</i> by Accidental Exposure during Short-Course Therapy with Cotrifazid<sup>TM</sup>

U¹,

Dingfelder²,

Urbanczik³

1997

Chemotherapy

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Cotrifazid – An Agent against Malaria

Cited by 10 publications

References 8 publications

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Treatment of Malaria tropica with a Fixed Combination of Rifampicin, Co-Trimoxazole and Isoniazid: A Clinical Study

Improbability of Selection for RIF Resistance in <i>Mycobacterium tuberculosis</i> by Accidental Exposure during Short-Course Therapy with Cotrifazid<sup>TM</sup>

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