Cough Variant Asthma: A Review of the Clinical Literature

Johnson, David C.; Osborn, Lucy M.

doi:10.3109/02770909109082732

Cited by 116 publications

(67 citation statements)

References 9 publications

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“…Chronic cough is often considered an occult form of asthma [37,41]. In the present study, the children with dry cough as their only chronic respiratory symptom formed an intermediate group that differed clearly both from the children with asthmatic symptoms and the children with no respiratory symptoms.…”

Section: Discussionmentioning

confidence: 56%

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Timonen¹,

Pekkanen²,

Korppi³

et al. 1995

Eur Respir J

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P Pr re ev va al le en nc ce e a an nd d c ch ha ar ra ac ct te er ri is st ti ic cs s o of f c ch hi il ld dr re en n w wi it th h c ch hr ro on ni ic c r re es sp pi ir ra at to or ry y s sy ym mp pt to om ms s i in n e ea as st te er rn n F Fi in nl la an nd d ABSTRACT: The objective of the present study was to assess the prevalence of asthma and asthma-related symptoms in Finland. We also wondered whether chronic cough may be an indicator of occult asthma. Prevalence and characteristics of children with doctor-diagnosed asthma and chronic respiratory symptoms were investigated in 7-12 year old school children from eastern Finland by using a questionnaire on respiratory symptoms. In addition, skin-prick tests, flow-volume spirometry, and serum total immunoglobulin E (IgE) measurements were performed in children reporting chronic respiratory symptoms.The parent-reported prevalence of doctor-diagnosed asthma was 4.4%, of wheezing 5.4%, of attacks of shortness of breath with wheezing 4.6%, and of dry cough at night 12%. Children with dry cough only (n=195) had less frequent parental asthma, self-reported allergies, daily respiratory medication, and moisture stains or molds at home than asthmatic children (n=180), but these findings were more frequent than among asymptomatic children (n=2,169). The prevalence of at least one positive skin-prick test result was 79% among the asthmatic children and 55% among children with dry cough only. There were no differences between the two symptom groups in serum total IgE levels and spirometric lung functions, except in maximal mid-expiratory flow (MMEF) values, which were significantly lower among children with asthmatic symptoms.The present results support the hypothesis that chronic cough may be an indicator of occult asthma. Therefore, to improve the sensitivity of respiratory questionnaires designed to detect asthma, they should also include questions on chronic cough. In contrast to what has been suggested previously, the prevalence of childhood asthma in eastern Finland was similar to the prevalences reported from other parts of Finland and from other Western European countries.

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Section: Discussionmentioning

confidence: 56%

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Timonen¹,

Pekkanen²,

Korppi³

et al. 1995

Eur Respir J

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“…It is associated with airway hyper-responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night and in the early morning 2 . These episodes are usually associated with widespread but variable airflow obstruction within the lung that is often reversible either spontaneously or with treatment 3 . According to the first national asthma prevalence study (NAPS) in Bangladesh about 7 million people (5.2%) are suffering from current asthma and more than 90% do not take modern treatment 4 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and Demographic Profiles of Patients Diagnosed as Cough Variant Asthma attended at Tertiary Referral Hospital

Hossain

Islam

Rahman

et al. 2017

J. Natl Inst. Neurosci Bangladesh

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“…[5][6][7][8][9] The etiological basis for effective management of asthma needs bronchiodialator action as reliever medication, anti-inflammatory as preventive medication and long acting β2 agonist as symptom controller. [10][11] Cough variant asthma (CVA) is one of the commonest forms of asthma characterized by an unproductive dry cough as the main or only symptoms and CVA patients has a more sensitive cough reflex.…”

Section: Introductionmentioning

confidence: 99%

Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma

Srivastava¹,

Siddharth²,

Hemant³

et al. 2015

Phcog J

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Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Anti-tussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1% histamine and 2% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6% w/v exhibit decrease in of the average coughs frequency (4.83 ± 0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75% and decreases number of coughs SUMMARY• The present study investigated a potential curative effect of ethanolic extract of Woodfordia fruticosa (L.) Kurz in Aerosol induced Cough Variant Asthma.• As none of any model exists to assess the activity of the drug for CVA, so our study also aimed to develop an effective pharmacological screening model for CVA.• The extract not only protects the animals from bron¬choconstriction and bronchospasm but also suppress the cough frequency, which almost covers the basic etiological relevance for CVA, which pharmacologically corroborates its effective treatment against CVA.

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Cough Variant Asthma: A Review of the Clinical Literature

Cited by 116 publications

References 9 publications

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Clinical and Demographic Profiles of Patients Diagnosed as Cough Variant Asthma attended at Tertiary Referral Hospital

Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma

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