Could a Mohs technique make Neuro<scp>SAFE</scp> a viable option?

Oxley, Jon; Bray, Adam; Rowe, Edward

doi:10.1111/bju.14377

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…A total of 12 studies described a systematic wedge approach to sample the posterolateral aspect of the specimen, the same (or similar) to the one described by Schlomm et al in 2012. To reduce time, Oxley et al suggested a slice (‘Mohs’) section of the posterolateral aspect of the prostate (Fig. b); the article has not been included as it was a ‘proof‐of‐concept’ study.…”

Section: Evidence Synthesismentioning

confidence: 99%

Positive surgical margin during radical prostatectomy: overview of sampling methods for frozen sections and techniques for the secondary resection of the neurovascular bundles

et al. 2020

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ConclusionsThere is no homogeneity in prostate sampling for FS analysis, although most recent evidence is moving toward a systematic sampling of the entire NS area. The management of a PSM is variable and can be affected by the sampling strategy (difficult localisation of the persisting tumour at the NVB). The difficult identification of the exact soft tissue location contiguous to a PSM could be considered as the critical point of FS analysis and of spared-NVB management.

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Section: Evidence Synthesismentioning

confidence: 99%

Positive surgical margin during radical prostatectomy: overview of sampling methods for frozen sections and techniques for the secondary resection of the neurovascular bundles

et al. 2020

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“…Nevertheless, the study from Schlomm et al (29), demonstrated that when applied systematically to the posterolateral margin of the prostate, FS at this site may improve the rate of NS procedures while preserving a negative margin status. Remarkably, the NeuroSAFE approach as described by the authors requires a dedicated setup, with a fully equipped laboratory including cryostats, technicians handling and preparing the specimen, pathologists on-site ready to interpret it and to provide the surgeon an immediate evaluation of the specimen (30). Overall, the NeuroSAFE requires 35 minutes in facilities with an appropriate setup, thus being not affordable in all pathological departments (30).…”

Section: Digital Biopsy During Radical Prostatectomymentioning

confidence: 99%

“…Remarkably, the NeuroSAFE approach as described by the authors requires a dedicated setup, with a fully equipped laboratory including cryostats, technicians handling and preparing the specimen, pathologists on-site ready to interpret it and to provide the surgeon an immediate evaluation of the specimen (30). Overall, the NeuroSAFE requires 35 minutes in facilities with an appropriate setup, thus being not affordable in all pathological departments (30).…”

Section: Digital Biopsy During Radical Prostatectomymentioning

confidence: 99%

Current and future perspectives of digital microscopy with fluorescence confocal microscope for prostate tissue interpretation: a narrative review

et al. 2021

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Fluorescence confocal microscopy (FCM) is an optical imaging technique providing digital microscopical images of fresh tissue in a real time fashion, without conventional processing. FCM has been widely applied in several fields of dermatology, including the detection of basal cell carcinoma and of cutaneous inflammatory diseases. The aim of the paper is to provide an overview of FCM applications in the field of prostate tissue interpretation and prostate cancer (PCa) detection. A Literature search (PubMed & Web of Science) was performed to identify articles concerned with the clinical and surgical applications of FCM in prostatic and periprostatic tissues interpretation. Overall, six articles were identified. All articles investigated the level of agreement between FCM and conventional histopathological analysis (hematoxylineosin, HE) for the discrimination between normal and PCa tissues. An investigative article on prostate samples retrieved from radical prostatectomy (RP) specimens and an atlas of FCM digital images from the same series were found. Two prospective clinical trials, comparing FCM and HE, pointed out a "substantial" to "almost perfect" discriminative performance of FCM for the diagnosis of PCa on prostate biopsy core.Finally, two studies investigated the intra-operative role of FCM during RP for the control of surgical dissection. In this setting, FCM could be used to analyse samples retrieved from suspicious peri-prostatic areas; FCM has also been tested for an en-face evaluation of flat slices obtained from the systematic sampling of the posterolateral aspects of the prostate, in a NeuroSAFE-like approach. Generally, FCM provides digital microscopical images of fresh tissue in a real time fashion, without requiring conventional processing.Currently, available studies confirmed a high concordance with conventional pathology for the detection of PCa. Further studies are required to validate the technology, to evaluate ISUP score attribution and to implement the fields of application of FCM for the treatment of prostate diseases.

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“…Interestingly, Oxley et al . [3] proposed the Mohs section of the posterolateral prostate surface to expedite the NeuroSAFE process. Mohs represents the standard of care for dermatological oncology surgery, especially in areas where the preservation of adjacent tissue to the cancer is advisable (e.g.…”

Section: Figmentioning

confidence: 99%

“…Mohs represents the standard of care for dermatological oncology surgery, especially in areas where the preservation of adjacent tissue to the cancer is advisable (e.g. face) [3]. The Mohs technique consists of a tangentially retrieved section, resulting in a sample that can be analysed en face to check for oncological margin safety ( Fig.…”

mentioning

confidence: 99%

Digital frozen section of the prostate surface during radical prostatectomy: a novel approach to evaluate surgical margins

et al. 2020

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Could a Mohs technique make NeuroSAFE a viable option?

Cited by 9 publications

References 4 publications

Positive surgical margin during radical prostatectomy: overview of sampling methods for frozen sections and techniques for the secondary resection of the neurovascular bundles

Positive surgical margin during radical prostatectomy: overview of sampling methods for frozen sections and techniques for the secondary resection of the neurovascular bundles

Current and future perspectives of digital microscopy with fluorescence confocal microscope for prostate tissue interpretation: a narrative review

Digital frozen section of the prostate surface during radical prostatectomy: a novel approach to evaluate surgical margins

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