Could Growth Differentiation Factor-15 Be a New Inflammatory Pathway in Psoriasis Vulgaris?

Abstract

Objective: Psoriasis vulgaris is a chronic inflammatory disease, in which T cells play an important role in the etiopathogenesis and inflammatory mechanisms. Growth differentiation factor (GDF) 15 is a member of the transforming growth factor beta superfamily (TGF-ß), which increases with inflammation and has various cell regulatory functions. In this study; It was aimed to evaluate the relationship between serum GDF-15 level and Tumor necrosis factor alpha (TNF-α), which is thought to have a role in the etiopathogenesis of the disease, and other metabolic parameters.
 Materials and methods: Forty-one patients with psoriasis vulgaris and 41 healthy controls were included in the study. Dermatological examination of all patients was performed and PASI score was calculated. Height and weight measurements, systolic and diastolic blood pressures, waist and hip circumferences, lipid profiles, and biochemical parameters of the patients were evaluated. Serum GDF-15 and TNF-α levels were measured by ELISA method.
 Results: There was no significant difference between the patient and control groups in terms of age, gender, lipid profiles, biochemical parameters and hs-CRP levels. Serum GDF-15 and TNF-α levels were found to be significantly higher in the patient group compared to the control group (p