Could mean platelet volume among complete blood count parameters be a surrogate marker of metabolic syndrome in pre-pubertal children?

Aypak, Cenk; Türedi, Özlem; Bircan, Mustafa; Yüce, Adnan

doi:10.3109/09537104.2013.827783

Cited by 20 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, decreased MPV was regarded as an enhanced consumption of large PLTs in inflammatory states 30 ) . In fact, the results of our study were in concordance with the results of two recent studies 31 , 32 ) . In those studies, the researchers also found that MPV was significantly lower in obese female subjects and showed that MPV was inversely associated with the degree of obesity, independent of confounding factors.…”

Section: Discussionsupporting

confidence: 93%

Association between mean platelet volume and bone mineral density in postmenopausal women

et al. 2016

Self Cite

View full text Add to dashboard Cite

[Purpose] Osteoporosis is an inflammatory disease, and platelets play a critical role in bone remodeling. Mean platelet volume has been shown to be influenced by inflammation. Our aim was to evaluate the relationship between mean platelet volume and bone mineral density in postmenopausal women. [Subjects and Methods] The records of female patients who had been referred to a tertiary hospital for bone mineral density analysis were retrospectively reviewed. [Results] A total of 175 patients (mean age: 61.3 ± 9.0 years) were enrolled. Overall, 72% (126/175) of patients met the criteria for osteoporosis. Mean platelet volume was found to be inversely correlated with body mass index. There was a significant positive correlation between mean platelet volume and femoral neck bone mineral density in our normal weight osteoporotic group, whereas there was a significant negative correlation in our overweight-obese osteoporotic group. The negative correlation between mean platelet volume and femoral neck bone mineral density in the overweight-obese osteoporotic group persisted after adjustment for confounding factors. Multivariate analyses revealed that mean platelet volume was significantly associated with femoral neck bone mineral density in osteoporotic patients in both our normal weight and overweight-obese groups. [Conclusion] Regardless of mechanisms, mean platelet volume might be used as a biomarker for osteoporosis in clinical settings.

show abstract

Section: Discussionsupporting

confidence: 93%

Association between mean platelet volume and bone mineral density in postmenopausal women

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…So it can be deduced that PLT is positively correlated with MS in women. [ 16 , 40 , 41 ] Second, men are found to have higher MS prevalence than women due to lack of the protection of female sex hormone. [ 31 ] Female sex hormone is generally believed to decrease the risk of MS. Nagata et al [ 42 ] suggested that autocrine estradiol secretion could increase PLT production by triggering pro-PLT formation.…”

Section: Discussionmentioning

confidence: 99%

The associations between leukocyte, erythrocyte or platelet, and metabolic syndrome in different genders of Chinese

Zhou

Meng²,

Liu³

et al. 2016

Medicine

View full text Add to dashboard Cite

Leukocyte, erythrocyte or platelet and metabolic syndrome (MS) are closely correlated, and there exist gender differences. We aimed to explore the associations between the hematological parameters and MS in different genders of Chinese. This cross-sectional study included 32,900 participants (20,733 males, 12,167 females) who were enrolled in a health examination. Clinical data including anthropometric measurements and serum parameters were collected. The associations between hematological parameters and MS of both genders were analyzed separately. Odds ratio (OR) of MS was calculated by binary logistic regression models. All hematological parameters were related to MS. With leukocyte and erythrocyte counts rising, the risks of developing MS increased in both genders, which was more obvious in women. For instance, in model 3, the ORs of MS in leukocyte quartiles in females were from 1.333 to 2.045 (P < 0.01), while in males, from 1.238 to 1.675 (P < 0.01). Platelet seemed as a protective factor in males. Model 1 and model 3 in quartile 2 demonstrated ORs of 0.922 (P < 0.05) and 0.912 (P < 0.05). However, platelet acted as risk factor in female. For instance, the ORs were 1.253 (P < 0.01), 1.461 (P < 0.01), and 1.322 (P < 0.01) in platelet quartile 4 of all 3 models in female. Gender has influences on the associations between leukocyte, erythrocyte or platelet, and MS. In both genders, higher levels of leukocyte and erythrocyte increased risks of MS. For men, platelet was a protective factor, but for women, platelet seemed as a risk factor.

show abstract

“…[5] The association of increased MPV, PDW, P-LCR, and platelet count with diseases related to endothelial dysfunction such as metabolic syndrome, diabetes, coronary artery disease (CAD), and malignancy has been shown in many studies. [6,7,8,9] The newer hematological analyzers are giving variety of platelet parameters which helps in easy detection of change in platelet structure, which may help in early detection of prothrombotic state of the platelets. These can act as an alarm for diagnosing initiation/progression of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

An Evaluation study of Platelet Volume Indices (PVI) in Type-2 Diabetes Mellitus and its Micro and Macro Vascular Complications

Desai¹,

Lakum

2018

APALM

View full text Add to dashboard Cite

Background:The study was performed to analyse PVI such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletlarge cell ratio (P-LCR) that are useful for identifying large and haemostatically active platelets, which are risk factors for developing diabetes and its complication.Methods: Case-control study was conducted on 1026 Type 2 diabetics and 616 nondiabetics. Detailed clinical history regarding duration, hypertension and complications was taken. PVI was obtained using three part automated cell counter. Fasting blood glucose, hemoglobin A1C, lipid profile, creatinine were also obtained. Diabetics were further categorized into patients with complications and without complications.Result: MPV, PDW, P-LCR and platelet count were significantly increased in diabetic patients with complications as compared to diabetics without complications and nondiabetic group (P < 0.0001, < 0.0001, 0.0044, 0.023 respectively). We found statistically significant correlation between MPV and diabetic retinopathy (P < 0.0001), nephropathy (P = 0.04), neuropathy (P < 0.0001), coronary artery disease (P < 0.0001), diabetic foot (P = 0.005). PDW was statistically significantly increased in diabetic retinopathy (P < 0.0001), neuropathy (P < 0.0001), coronary artery disease (P < 0.0001), diabetic foot (P = 0.005). P-LCR was statistically significantly increased in diabetic retinopathy (P < 0.0001), neuropathy (P = 0.003), coronary artery disease (P < 0.0001), diabetic foot (P = 0.034). Conclusion:MPV, PDW and P-LCR are predictive biomarkers of diabetic vascular complications. They are more significant in microvascular complications than macrovascular complications.

show abstract

Could mean platelet volume among complete blood count parameters be a surrogate marker of metabolic syndrome in pre-pubertal children?

Cited by 20 publications

References 40 publications

Association between mean platelet volume and bone mineral density in postmenopausal women

Association between mean platelet volume and bone mineral density in postmenopausal women

The associations between leukocyte, erythrocyte or platelet, and metabolic syndrome in different genders of Chinese

An Evaluation study of Platelet Volume Indices (PVI) in Type-2 Diabetes Mellitus and its Micro and Macro Vascular Complications

Contact Info

Product

Resources

About