Could mean platelet volume be a predictive marker for gestational diabetes mellitus?

Erikçi, Alev Akyol; Muhçu, Murat; Dündar, Özgür; Öztürk, Ahmet

doi:10.1179/102453308x315825

Cited by 38 publications

(40 citation statements)

References 9 publications

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“…A significant difference in platelet count was not observed between the studies of Bozkurt et al (13) and Erdogan et al (10). The platelet count was found significantly lower than the control in the study of Erikçi et al (14). There are also studies in which the levels of platelet count were determined significantly higher in patients with GDM (11,15).…”

Section: Discussionmentioning

confidence: 51%

“…Significant changes have not been found in neither PLR nor NLR in the study of Sargin et al (18). A number of studies have revealed the increase of MPV in patients with the GDM (13,14,19) however this issue is also contradictory. Sahbaz et al (11) have conducted a retrospective study on 59 GDM patients and the MPV level was higher than the level of healthy group but Erdogan et al (10) have not found a significant change in their study in patients with GDM.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

Yıldız¹,

Üçler²,

Alay³

et al. 2016

Eastern J Med

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 52%

Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

Yıldız¹,

Üçler²,

Alay³

et al. 2016

Eastern J Med

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“…[4] Large platelets are more active than smaller platelets and produce more prothrombotic factors and this indicates that changes in the platelet count and MPV reflect the state of thrombogenesis. [4] Mean platelet volume of patients with type 2 DM are higher than controls [5,6] and patients with GDM also have higher MPV, [7,8] yet other studies present contradictory results. [9] In this study we measured MPV in patients with GDM and compared it to nondiabetics and tried to determine the correlation of MPV with postprandial plasma glucose in patients diagnosed with GDM.…”

mentioning

confidence: 78%

“…There was also no correlation between MPV and fasting blood glucose levels of pregnants with GDM. Previously two studies detected higher MPV in patients with GDM when compared to the control group, [7,8] but they did not check the presence of correlation between MPV and glucose levels. Other studies in patients with type 2 DM detected statistically significantly higher MPV in diabetic group when compared to nondiabetic subjects.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume in gestational diabetes mellitus

Güdücü¹

2015

FNG & Bilim Tıp Dergisi

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Objectives:This study aims to compare mean platelet volume of pregnants with gestational diabetes mellitus to a healthy control group and to detect the relationship between mean platelet volume and fasting blood glucose. Materials and methods: Patients with gestational diabetes mellitus (n=43) were compared to a healthy control group (n=43) retrospectively by searching medical records. Results: Platelet count and mean platelet volume of patients with gestational diabetes mellitus and the control group were not statistically significantly different. There was no statistically significant correlation between mean platelet volume and fasting blood glucose of patients with gestational diabetes mellitus (r=-0.207, p=0.189). Complete blood count results of the two groups were compared, only hemoglobin levels were statistically significantly different. Conclusion: There was no difference in mean platelet volume of patients with gestational diabetes mellitus and controls. There was also no relationship between mean platelet volume and fasting blood glucose of patients with gestational diabetes mellitus.Keywords: Gestational diabetes mellitus; hemoglobin level; mean platelet volume.Gestasyonel diabetes mellitusu olan gebelerde ortalama trombosit hacmi ÖZ Amaç: Bu çalışmada sağlıklı kontrol grubunu oluşturan gebeler ve gestasyonel diabetes mellitus olanların ortalama trombosit hacimleri karşılaştırıldı ve ortalama trombosit hacmi ile açlık kan şekeri arasındaki ilişki araştırıldı. Gereç ve yöntemler: Tıbbi kayıtları retrospektif olarak araştırılarak gestasyonel diabetes mellitusu olan hastalar (n=43), sağlıklı gebe kontrol grubu (n=43) ile karşılaştırıldı. Bulgular: Kontrol grubunu oluşturan sağlıklı gebelerde ve gestasyonel diabetes mellitusu olanlarda yapılan trombosit sayımı ve ortalama trombosit hacmi arasında istatistiksel olarak anlamlı fark bulunmadı. Gestasyonel diabetes mellitusu olan hastaların açlık kan şekeri ve ortalama trombosit hacmi arasında da istatistiksel olarak anlamlı ilişki bulunmadı (r=-0,207, p=0.189). Her iki grubun tüm kan sayımı parametreleri karşılaştırıldığında, sadece hemoglobin seviyelerinde istatistiksel olarak anlamlı farklılık bulundu. Sonuç: Kontrol grubunu oluşturan sağlıklı gebeler ve gestasyonel diabetes mellitus olan hastalardaki ortalama trombosit hacmi arasında anlamlı bir fark yoktur. Ayrıca gestasyonel diabetes mellitus olan hastaların açlık kan şekerleri ile ortalama trombosit hacmi arasında bir ilişki bulunamamıştır.

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“…Tip 1 diyabet hastalarında trombosit aktivasyonu kötü metabolik kontrol ile birliktelik gösterebilir (11). Kan şekeri etkili bir şekilde düştüğünde MPV anlamlı olarak azalır (6). MPV düzeyleri diyabetik hastalarda kontrol grubuna göre daha yüksektir (12).…”

Section: Introductionunclassified

Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes?

Balkan¹,

Usluoğulları²,

Cler³

et al. 2014

Gaziantep Med J

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An abnormal glucose tolerance which is first detected during pregnancy and disappears after completion of pregnancy is known as "gestational diabetes mellitus". Early detection of this condition helps preventing potential maternal and fetal complications. Some studies reported that platelets may have a role in the pathogenesis and development of gestational diabetes. In the present study, we aimed to evaluate and compare the platelet function and morphology among pregnant women with gestational diabetes and healthy pregnant women. Values of complete blood count were reviewed for pregnant women between weeks 24 and 28 of gestation while performing oral glucose tolerance tests for from January 2013 to September 2013. After screening, a total of 89 pregnant women were enrolled in the study including 38 women with gestational diabetes and 51 healthy pregnant women. The mean platelet volume (MPV) was 8.76 ± 1.53 fl in the group with gestational diabetes and 7.80 ± 1.34 fl in the healthy pregnant group, with a statistically significant difference between two groups (P=0.02). There was no statistically significant difference between two groups in platelet counts (P=0.25). Dissimilar results were reported by a small number of studies on this subject. MPV and other platelet parameters may be considerably helpful in detecting diabetic pregnant women who are at risk for vascular complications. In this study, significantly greater MPV was found among pregnant women with gestational diabetes compared to control group (P<0.05). Further studies are needed to elucidate the role of such changes and their potential clinical implications in women with gestational diabetes.

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Could mean platelet volume be a predictive marker for gestational diabetes mellitus?

Abstract: Our results indicate that platelet count and MPV play an important predictive role in gestational diabetes mellitus.

Cited by 38 publications

References 9 publications

Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

Mean platelet volume in gestational diabetes mellitus

Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes?

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