Could nanoparticle systems have a role in the treatment of cerebral gliomas?

Caruso, Gerardo; Caffo, Maria; Alafaci, Concetta; Raudino, Giuseppe; Cafarella, D.; Lucerna, Sebastiano; Salpietro, Francesco M.; Tomasello, Francesco

doi:10.1016/j.nano.2011.02.008

Cited by 77 publications

(43 citation statements)

References 64 publications

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“…MRI provides detailed information on anatomy and function, and this technique is commonly used for cell tracking assays in vivo in combination with contrast agents, such as superparamagnetic iron oxide nanoparticles (SPIONs). The growing interest related to the use of contrast agents to visualize the migration and growth of cells (e.g., stem cells or tumor cells) has made MRI a particularly interesting technique, as it can enable monitoring studies of cell migration and homing in vivo (8)(9)(10)(11) . Cells labeled with SPIONs for both in vivo and in vitro assays induce a strong contrast in T 2 maps, which facilitates the monitoring of grafted cells.…”

Section: Introductionmentioning

confidence: 99%

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

Mamani

Malheiros

Cardoso

et al. 2012

Einstein (São Paulo)

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Objective: The aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with the goal of aiding in tumor prognosis and therapy. Methods: Two groups of male Wistar rats were used for the tumor induction model. In the first group (n=3), the tumors were induced via the injection of SPION-labeled C6 cells. In the second group (n=3), the tumors were induced via the injection of unlabeled C6 cells. Prussian Blue staining was performed to analyze the SPION distribution within the C6 cells in vitro. Tumor-inducing C6 cells were injected into the right frontal cortex, and subsequent tumor monitoring and SPION detection were performed using T 2 -and T 2 *-weighted MRI at a 2T field strength. In addition, cancerous tissue was histologically analyzed after performing the MRI studies. Results: The in vitro qualitative evaluation demonstrated adequate distribution and satisfactory cell labeling of the SPIONs. At 14 or 21 days after C6 injection, a SPIONinduced T 2 -and T 2 *-weighted MRI signal reduction was observed within the lesion located in the left frontal lobe on parasagittal topography. Moreover, histological staining of the tumor tissue with Prussian Blue revealed a broad distribution of SPIONs within the C6 cells. Conclusion: MRI analyses exhibit potential for monitoring the tumor growth of C6 cells efficiently labeled with SPIONs.

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Section: Introductionmentioning

confidence: 99%

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

Mamani

Malheiros

Cardoso

et al. 2012

Einstein (São Paulo)

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“…This is especially true considering that anaplastic astrocytoma and glioblastomas are among the most vascularized tumors and show a diffuse infiltrative growth resulting in an incomplete resection of the tumor mass and leading to recurrence [64]. For several years; nano-sized materials are in the focus as a promising therapeutical tool and offer ideal opportunities for targeted drug delivery [65,66]. Nanoparticles (ranging from 1-1000 nm in size) are intensively investigated particularly with regard to their carrier capacity and to drive them across the BBB to the tumor site.…”

Section: Discussionmentioning

confidence: 99%

Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study

Sack-Zschauer¹,

Bader²,

Brenneisen³

2017

J Nanomed Nanotechnol

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“…23 Liposomes composed of phospholipids, phosphatidylcholine, and cholesterol and the characteristics depend on the nature of the ingredients. The liposomes are used as non-viral carrier for drug and macromolecule for targeting wide variety of cells.…”

Section: Liposomesmentioning

confidence: 99%

Nanoparticles for the Treatment of Lung Cancers

Raahulan¹,

Mallukaraj²,

Kadavakollu³

et al. 2018

JYP

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On the row of various cancers in the world, the Lung cancer falls to number two in both female and male. Various surgical and non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, and radiotherapy are employed in the treatment of lung cancer. However, most of these techniques are costly, complex and lacks patient compliance. In case of chemotherapy, it is associated with lack of specific tumour targeting, with limited drug solubility leads insufficient amount of drug reaches to a tumor site. To overcome these demerits associated with chemotherapy, various types of nanoparticles (both organic and inorganic) are synthesized and studied in treating lung cancers. In this article, we have reviewed the various types of nanoparticles that have been used in treating lung cancers. This review was carried out by searches of relevant published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles. The following search terms were used: Lung cancer, Target delivery, animal models, Nanoformulation, Nanoparticles and Polymeric Nanoparticles.

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Could nanoparticle systems have a role in the treatment of cerebral gliomas?

Cited by 77 publications

References 64 publications

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study

Nanoparticles for the Treatment of Lung Cancers

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