Could Sumac Be Effective on COVID-19 Treatment?

Korkmaz, Hasan

doi:10.1089/jmf.2020.0104

Cited by 25 publications

(21 citation statements)

References 37 publications

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“…18 In a study conducted with carvacrol, it was demonstrated that the treatment resulted in reduced alveolar dilatation, macrophage density and IL-1β, IL-6, IL-8 and IL-17 levels in bronchoalveolar lavage fluid. 19 Based on these antiviral effects of herbal therapies, it is believed that the alternative treatments may be effective for COVID-19 infection, for which a definitive treatment has not yet been found, and which has become a part of our lives for almost a year. Carvacrol, which is a component of thyme called essential oils, has been emphasized for its anti-inflammatory, antioxidant, immunomodulatory and antiviral effects.…”

Section: Discussionmentioning

confidence: 99%

A google trends analysis: evaluation of the search frequency about alternative treatment methods during the COVID-19 pandemic in Turkey

Alsancak¹

2021

IJCAM

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Objective: A rapidly grown up information about COVID-19 has been regularly broadcast on internet websites or social media. In this period, it can be argued that there has been an increase in the online search about the COVID-19 infection, disease prevention or treatment methods. We investigated the Google research trends in searches of alternative treatment methods during the COVID-19 pandemic in Turkey. Methods:The Google Trends TM (GT TM) was used to retrieve data on Internet user search activities and patterns of Google search queries. We searched most known keywords related to alternative and herbal therapies such as thyme, sumac, ginger, tonics, propolis, Vitamin

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Section: Discussionmentioning

confidence: 99%

A google trends analysis: evaluation of the search frequency about alternative treatment methods during the COVID-19 pandemic in Turkey

Alsancak¹

2021

IJCAM

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“…Therefore, the anti-viral abilities of flavonoids and phenolic compounds may also apply in the current Covid-19 pandemic. The potentially beneficial role of polyphenols in the Covid-19 pandemic is currently a widely debated topic [78][79][80]. One of the recommended targets of SARS-CoV-2 treatments is the ACE-2 receptor [81].…”

Section: Flavonoids and Phenolic Compounds In Covid-19mentioning

confidence: 99%

Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?

Gelen¹,

Kükürt²,

Şengül³

et al. 2022

Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications

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Covid-19 is the causative agent of a beta coronavirus that causes severe inflammatory pneumonia, so excessive inflammation is considered a risk factor for the disease. In Covid-19 disease, an inflammatory response develops in the body. It has been reported as a result of various studies that this response causes damage to various organs and tissues, especially the lungs. According to reports, cytokine storms are largely responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Many studies are showing that there may be various agents to prevent or treat these effects of Covid-19 disease. Some of these agents are phenolic compounds. Phenolic compounds are the most abundant substances in vegetables and fruits. Inflammasomes, their function. It has been stated that phenolic compounds inhibit inflammation by inhibiting cytosolic multiprotein complexes that assemble in response to cytosolic pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs) to form active forms of IL-1β and IL-18. It suggested that Apigenin, Resveratrol, Morin, and Silymarin an anti-inflammatory, antioxidant, anti-viral, and anti-microbial compound could be a potential therapeutic agent for severe inflammation from Covid-19.

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“…e protease enzyme (6LU7) has been successfully crystallized and deposited in the Protein Data Bank (PDB) [40,41]; thus, it is considered as a potential target for therapeutic strategies, particularly for those who use phytochemicals [7,42,43]. It was reported that an evaluation of up-to-date knowledge relating to the characteristics of COVID-19 infection and complications encourages the investigation of the effectiveness of sumac extracts for COVID-19 treatment [44][45][46][47][48]. Recently, active metabolites from 14 cooking seasonings were examined as inhibitors for SARS-CoV-2 main protease (M pro ).…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

“…(sumac) constituents could have a higher potency against the consequences produced by SARS-CoV-2 during human infection. e review study demonstrated that sumac could be useful in COVID-19 infection due to its versatile activities as anti-inflammatory, antimicrobial, antioxidant, and antimalarial effects [48]. In addition, the review article along with others mentioned that use of sumac as syrup or in capsules with different concentrations has no toxicity on human life and could be recommended in treatment protocol for COVID-19 patients [18,[48][49][50][51].…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

“…Regarding previous molecular docking studies [12,18,36,[44][45][46][47][48][49][50][51][52], we are trying to explore the potential inhibitory effects of some Rhus spp. (sumac) constituents against the SARS-CoV-2 main protease enzyme using molecular docking, drug likeness, and synthetic accessibility score analysis.…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

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Phytochemicals of Rhus spp. as Potential Inhibitors of the SARS-CoV-2 Main Protease: Molecular Docking and Drug-Likeness Study

Sherif

Gabr

Hosny

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The outbreak of coronavirus disease 2019 (COVID-19) induced by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China and spread to cover the entire world with an ongoing pandemic. The magnitude of the situation and the fast spread of the new and deadly virus, as well as the lack of specific treatment, led to a focus on research to discover new therapeutic agents. Aim. In this study, we explore the potential inhibitory effects of some active polyphenolic constituents of Rhus spp. (sumac) against the SARS-CoV-2 main protease enzyme (Mpro; 6LU7). Methods. 26 active polyphenolic compounds of Rhus spp. were studied for their antiviral activity by molecular docking, drug likeness, and synthetic accessibility score (SAS) as inhibitors against the SARS-CoV-2 Mpro. Results. The results show that all tested compounds of sumac provided good interaction with the main active site of SARS-CoV-2 Mpro, with better, lower molecular docking energy (kcal/mol) compared to the well-known drugs chloroquine and favipiravir (Avigan). Only six active polyphenolic compounds of Rhus spp. (sumac), methyl 3,4,5-trihydroxybenzoate, (Z)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-hydroxyprop-2-en-1-one, (Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chroman-4-one, 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chroman-4-one, and 3,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, were proposed by drug likeness, solubility in water, and SAS analysis as potential inhibitors of Mpro that may be used for the treatment of COVID-19. Conclusion. Six phenolic compounds of Rhus spp. are proposed for synthesis as potential inhibitors against Mpro and have potential for the treatment of COVID-19. These results encourage further in vitro and in vivo investigations of the proposed ligands and research on the preventive use of Rhus spp. against SARS-CoV-2.

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Could Sumac Be Effective on COVID-19 Treatment?

Cited by 25 publications

References 37 publications

A google trends analysis: evaluation of the search frequency about alternative treatment methods during the COVID-19 pandemic in Turkey

A google trends analysis: evaluation of the search frequency about alternative treatment methods during the COVID-19 pandemic in Turkey

Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?

Phytochemicals of Rhus spp. as Potential Inhibitors of the SARS-CoV-2 Main Protease: Molecular Docking and Drug-Likeness Study

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