Could Targeted, Antibiotic-Loaded Gold Nanoconstructs be a New Magic Bullet to Fight Infection?

Meeker, Daniel G.; Chen, Jingyi; Smeltzer, Mark S.

doi:10.2217/nnm-2016-0260

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…To effectively combat biofilm formation, it is crucial to target both penetration and antibiotic resistance through a concurrently coupled targeted therapy. The concept of the magic bullet, introduced by Paul Erlich, emphasizes that drug targeting should deliver the drug to the right location, with the right concentration, and for the right duration [141] Broadly hypothesized, nanotechnology serves as the magic bullet for antibiofilm treatment [142].…”

Section: Nano-therapeutics As a Magic Bullet For Biofilm Eradicationmentioning

confidence: 99%

Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances

Aboelnaga,

Elsayed,

Abdelsalam

et al. 2024

Cell Commun Signal

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Methicillin-resistant Staphylococcus aureus (MRSA) represents a global threat, necessitating the development of effective solutions to combat this emerging superbug. In response to selective pressures within healthcare, community, and livestock settings, MRSA has evolved increased biofilm formation as a multifaceted virulence and defensive mechanism, enabling the bacterium to thrive in harsh conditions. This review discusses the molecular mechanisms contributing to biofilm formation across its developmental stages, hence representing a step forward in developing promising strategies for impeding or eradicating biofilms. During staphylococcal biofilm development, cell wall-anchored proteins attach bacterial cells to biotic or abiotic surfaces; extracellular polymeric substances build scaffolds for biofilm formation; the cidABC operon controls cell lysis within the biofilm, and proteases facilitate dispersal. Beside the three main sequential stages of biofilm formation (attachment, maturation, and dispersal), this review unveils two unique developmental stages in the biofilm formation process for MRSA; multiplication and exodus. We also highlighted the quorum sensing as a cell-to-cell communication process, allowing distant bacterial cells to adapt to the conditions surrounding the bacterial biofilm. In S. aureus, the quorum sensing process is mediated by autoinducing peptides (AIPs) as signaling molecules, with the accessory gene regulator system playing a pivotal role in orchestrating the production of AIPs and various virulence factors. Several quorum inhibitors showed promising anti-virulence and antibiofilm effects that vary in type and function according to the targeted molecule. Disrupting the biofilm architecture and eradicating sessile bacterial cells are crucial steps to prevent colonization on other surfaces or organs. In this context, nanoparticles emerge as efficient carriers for delivering antimicrobial and antibiofilm agents throughout the biofilm architecture. Although metal-based nanoparticles have been previously used in combatting biofilms, its non-degradability and toxicity within the human body presents a real challenge. Therefore, organic nanoparticles in conjunction with quorum inhibitors have been proposed as a promising strategy against biofilms. As nanotherapeutics continue to gain recognition as an antibiofilm strategy, the development of more antibiofilm nanotherapeutics could offer a promising solution to combat biofilm-mediated resistance.

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Section: Nano-therapeutics As a Magic Bullet For Biofilm Eradicationmentioning

confidence: 99%

Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances

Aboelnaga,

Elsayed,

Abdelsalam

et al. 2024

Cell Commun Signal

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“…AuNRs have important chemical and biological applications such as bioimaging, treatment of cancer , and infection, label-free biosensing down to single molecules, surface-enhanced Raman spectroscopy, , fluorescence enhancement, drug delivery, and light harvesting to drive catalytic reactions . These applications heavily rely on tuning the morphology-dependent optical features of AuNRs, necessitating precise tailoring of their dimensions.…”

mentioning

confidence: 99%

Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer

et al. 2019

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Optical microresonators have widespread application at the frontiers of nanophotonic technology, driven by their ability to confine light to the nanoscale and enhance light–matter interactions. Microresonators form the heart of a recently developed method for single-particle photothermal absorption spectroscopy, whereby the microresonators act as microscale thermometers to detect the heat dissipated by optically pumped, nonluminescent nanoscopic targets. However, translation of this technology to chemically dynamic systems requires a platform that is mechanically stable, solution compatible, and visibly transparent. We report microbubble absorption spectrometers as a versatile platform that meets these requirements. Microbubbles integrate a two-port microfluidic device within a whispering gallery mode microresonator, allowing for the facile exchange of chemical reagents within the resonator’s interior while maintaining a solution-free environment on its exterior. We first leverage these qualities to investigate the photoactivated etching of single gold nanorods by ferric chloride, providing a method for rapid acquisition of spatial and morphological information about nanoparticles as they undergo chemical reactions. We then demonstrate the ability to control nanorod orientation within a microbubble through optically exerted torque, a promising route toward the construction of hybrid photonic-plasmonic systems. Critically, the reported platform advances microresonator spectrometer technology by permitting room-temperature, aqueous experimental conditions, which may be used for time-resolved single-particle experiments on non-emissive, nanoscale analytes engaged in catalytically and biologically relevant chemical dynamics.

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“…AuNRs 19 have important chemical and biological 20 applications such as bioimaging, 21 treatment of cancer 22,23 and infection, 24 label-free biosensing 25 down to single molecules, 26 surface-enhanced Raman spectroscopy, 27,28 fluorescence enhancement, 29 drug delivery, 30 and light harvesting to drive catalytic reactions. 31 These applications heavily rely on tuning the morphology-dependent optical features of AuNRs, necessitating precise tailoring of their dimensions.…”

mentioning

confidence: 99%

Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer

Hogan¹,

Horak²,

Ward³

et al. 2019

Preprint

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Optical microresonators have widespread application at the frontiers of nanophotonic technology, driven by their ability to confine light to the nanoscale and enhance light-matter interactions. Microresonators form the heart of a new method for single-particle photothermal absorption spectroscopy, whereby the microresonators act as microscale thermometers to detect the heat dissipated by optically pumped, non-luminescent nanoscopic targets. However, translation of this technology to chemically dynamic systems requires a platform that is mechanically stable, solution compatible, and visibly transparent. We report microbubble absorption spectrometers as a new and versatile platform that meets these requirements. Microbubbles integrate a two-port microfluidic device within a Whispering Gallery Mode (WGM) microresonator, allowing for the facile exchange of chemical reagents within the resonator’s interior while maintaining a solution-free environment on its exterior. We first leverage these qualities to investigate the photo-activated etching of single gold nanorods by ferric chloride, providing a new method for rapid acquisition of spatial and morphological information about nanoparticles as they undergo chemical reactions. We then demonstrate the ability to control nanorod orientation within a microbubble through optically exerted torque, a new route toward the construction of hybrid photonic-plasmonic systems. Critically, the reported platform advances microresonator spectrometer technology by permitting room-temperature, aqueous experimental conditions, opening a regime of time-resolved single-particle experiments on non-emissive, nanoscale analytes engaged in catalytically and biologically relevant chemical dynamics.

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Could Targeted, Antibiotic-Loaded Gold Nanoconstructs be a New Magic Bullet to Fight Infection?

Cited by 6 publications

References 19 publications

Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances

Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances

Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer

Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer

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