Could the Colonic Capsule PillCam Colon Be Clinically Useful for Selecting Patients Who Deserve a Complete Colonoscopy? Results of Clinical Comparison With Colonoscopy in the Perspective of Colorectal Cancer Screening

Gay, G.; Delvaux, Michel; Frederic, Muriel; Fassler, Isaac

doi:10.1038/ajg.2009.624

Cited by 60 publications

(63 citation statements)

References 27 publications

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“…Only two studies used PCC2 [Eliakim et al 2009;Spada et al 2011b]. Only four studies had a sample size of more than 100 [Van Gossum et al 2009;Gay et al 2010;Spada et al 2010Spada et al , 2011b.…”

Section: Resultsmentioning

confidence: 99%

“…Six of the studies were multicentered and were conducted in Israel [Eliakim et al 2006], Japan [Kakugawa et al 2012], Italy [Spada et al 2011c] and three across multiple countries in Europe [Eliakim et al 2006[Eliakim et al , 2009Spada et al 2011b]. The single-center studies were conducted in Spain [Eliakim et al 2009], Belgium [Schoofs et al 2006], Germany [Sieg et al 2009;Hartmann et al 2012], France [Gay et al 2010] and Italy [Spada et al 2011a]. Most of the studies were conducted with PillCam Colon 1 (PCC1).…”

Section: Resultsmentioning

confidence: 99%

“…In recent years colon capsule endoscopy (CCE) has been under evaluation for visualization of the colon [Eliakim et al 2006[Eliakim et al , 2009Schoofs et al 2006;Sieg et al 2009;Gay et al 2010;Spada et al 2010;Herrerias-Gutierrez et al 2011;Sieg, 2011]. The advantages of CCE as an alternative to the standard colonoscopy as a screening test for colorectal cancer (CRC) might be attractive for a subset of patients.…”

Section: Introductionmentioning

confidence: 99%

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Bowel preparation regimens for colon capsule endoscopy: a review

Singhal

Nigar

Paleti

et al. 2013

Therap Adv Gastroenterol

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Colon capsule endoscopy (CCE) is being actively evaluated as an emerging complementary or alternative procedure for evaluation of the colon. The yield of CCE is significantly dependent on the quality of bowel preparation. In addition to achieving a stool-free colon the bowel preparation protocols need to decrease bubble effect and aid propulsion of the capsule. An extensive English literature search was done using PubMed with search terms of colon capsule endoscopy, PillCam and bowel preparation. Full-length articles which met the criteria were included for review. A total of 12 studies including 1149 patients were reviewed. There was significant variability in the type of bowel preparation regimens. Large-volume (3-4 liters) polyethylene glycol (PEG) was the most widely used laxative. Lower volumes of PEG showed comparable results but larger studies are needed to determine efficacy. Sodium phosphate was used as an effective booster in most studies. Magnesium citrate and ascorbic acid are emerging as promising boosters to replace sodium phosphate when it is contraindicated. The potential benefit of prokinetics needs further evaluation. Over the past decade there has been significant improvement in the bowel preparation regimens for CCE. Further experience and studies are likely to standardize the bowel preparation regimens before CCE is adopted into routine clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bowel preparation regimens for colon capsule endoscopy: a review

Singhal

Nigar

Paleti

et al. 2013

Therap Adv Gastroenterol

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“…In an analysis of over 1600 reported cases involving both first-and second-generation CEs, the minor complication rate was 4.1 %, while the major complication rate was 0.49 %, not being directly related to CCE [25]. Reports stated that the major complication of perforation was derived from the particular performance of the colonoscopy, including the therapeutic interventions undertaken [44][45][46] (Table 2). Some case reports raised the possibility of capsule aspiration [47] and retention in a diverticulum [48].…”

Section: Complicationsmentioning

confidence: 99%

Colon capsule endoscopy: toward the future

Muguruma

Tanaka

Teramae

et al. 2017

Clin J Gastroenterol

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Colon capsule endoscopy is a wireless and minimally invasive technique for visualization of the whole colon. With recent improvements of technical features in second-generation systems, a more important role for colon capsule endoscopy is rapidly emerging. Although several limitations and drawbacks are yet to be resolved, its usefulness as a tool for colorectal cancer screening and monitoring disease activity in inflammatory bowel diseases has become more apparent with increased use. Further investigations, including multicenter trials, are required to evaluate the substantial role of the colon capsule in managing colorectal diseases.

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“…The Pillcam COLON capsule endoscopy (Given Imaging Ltd, Yoqneam, Israel) has also shown promising results as a new modality to evaluate for colorectal cancer screening [94][95][96][97][98][99][100][101]. It is in clinical trials in Europe.…”

Section: New Capsulesmentioning

confidence: 99%