Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis?

Dicks, Leon M. T.; Deane, Shelly M.; M, Grobbelaar

doi:10.1007/s12602-022-09925-5

Cited by 6 publications

(3 citation statements)

References 84 publications

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“…Syphacia obvelata is an internal parasite occasionally observed in chinchillas and ivermectin is a clinical treatment for the disease. However, ivermectin has antibacterial properties, which may lead to gastrointestinal disease by causing dysbacteriosis [ 8 , 11 ], so figuring out the influence of ivermectin on the gut microbiota of chinchillas is important.…”

Section: Discussionmentioning

confidence: 99%

“…Ivermectin is an antiparasitic, commonly used for controlling parasitic infestation in chinchillas by its oral or injectable formulation [ 3 , 9 , 10 ]. However, since it has antibacterial properties [ 11 ], the treatment of ivermectin may lead to the imbalance of gut microbiota, and that may promote the emergence and development of diseases [ 5 , 6 , 8 ]. A previous study found that combinative administration of fenbendazole and ivermectin tablets disturbed the homeostasis of gut microbiota and metabolism in Amur tiger [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera)

Luo

et al. 2023

Veterinary Sciences

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The gastrointestinal microbiota plays an important role in health of the host animals and the detrimental influence of pharmaceutical treatment on the fecal microbiota receives an increasing concern. The clinical use of ivermectin on chinchillas has not yet been evaluated. The purpose of our study was to assess the influence of ivermectin injection on the fecal bacterial microbiota of chinchillas. A with-in subject, before and after study was performed on 10 clinically healthy chinchillas during a 14-day period, all chinchillas received the same ivermectin treatment, and the microbiota from their fecal samples before and after administration were compared as two experimental groups. Fecal samples were collected on day 0 (before ivermectin administration) and day 14 (post ivermectin administration). Fecal bacterial microbiota was analyzed by bacterial 16S rRNA gene sequencing. No clinical abnormalities were observed post subcutaneous administration of ivermectin. No significant alteration was found in the abundance and diversity of fecal bacterial microbiota after treatment, but the dominant position of some bacterial species changed. In conclusion, ivermectin administration was associated with minimal alternations of the fecal bacterial microbiota in healthy chinchillas, and these changes had no observed negative effect on general health of chinchillas in short term.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera)

Luo

et al. 2023

Veterinary Sciences

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“…Furthermore, these tests were all performed in vivo, which makes it impossible to elucidate the effect of IVM on the gut microbiota specifically, as it is well known that the mammalian and microbial cells interact metabolically [30]. To date, an investigation of IVM's effect on the gut microbial community of healthy individuals has not been conducted [31], even though such studies could provide important safety information for those considering re-purposing IVM for alternative applications in which the subjects are not also infected with helminths.…”

Section: Of 15mentioning

confidence: 99%

Impact of Ivermectin on the Gut Microbial Ecosystem

Liu,

Mahalak,

Bobokalonov

et al. 2023

IJMS

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Ivermectin is a an anti-helminthic that is critical globally for both human and veterinary care. To the best of our knowledge, information available regarding the influence of ivermectin (IVM) on the gut microbiota has only been collected from diseased donors, who were treated with IVM alone or in combination with other medicines. Results thus obtained were influenced by multiple elements beyond IVM, such as disease, and other medical treatments. The research presented here investigated the impact of IVM on the gut microbial structure established in a Triple-SHIME® (simulator of the human intestinal microbial ecosystem), using fecal material from three healthy adults. The microbial communities were grown using three different culture media: standard SHIME media and SHIME media with either soluble or insoluble fiber added (control, SF, ISF). IVM introduced minor and temporary changes to the gut microbial community in terms of composition and metabolite production, as revealed by 16S rRNA amplicon sequencing analysis, flow cytometry, and GC-MS. Thus, it was concluded that IVM is not expected to induce dysbiosis or yield adverse effects if administered to healthy adults. In addition, the donor’s starting community influences the relationship between IVM and the gut microbiome, and the soluble fiber component in feed could protect the gut microbiota from IVM; an increase in short-chain fatty acid production was predicted by PICRUSt2 and detected with IVM treatment.

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The Impact of Gut Microbiota on Gender-Specific Differences in COVID-19 Patients

Sehli,

Rhalem,

Kettani

et al. 2024

Lecture Notes in Networks and Systems

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Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis?

Cited by 6 publications

References 84 publications

Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera)

Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera)

Impact of Ivermectin on the Gut Microbial Ecosystem

The Impact of Gut Microbiota on Gender-Specific Differences in COVID-19 Patients

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