Could the heat sink effect of blood flow inside large vessels protect the vessel wall from thermal damage during RF‐assisted surgical resection?

González-Suárez, Ana; Trujillo, Macarena; Burdı́o, Fernando; Andaluz, Anna; Berjano, Enrique

doi:10.1118/1.4890103

Cited by 15 publications

(12 citation statements)

References 51 publications

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“…Although tissue injury is the result of several complex mechanisms, thermal lesions created in the atrial wall can be reasonably approximated using an isotherm of 50 C in computer models [17,18] and thermal lesion contour in the experiments is assessed by the "white zone" [19].…”

Section: Assessment Of the Thermal Injurymentioning

confidence: 99%

Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation

Yan

Wang

2017

International Journal of Hyperthermia

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Section: Assessment Of the Thermal Injurymentioning

confidence: 99%

Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation

Yan

Wang

2017

International Journal of Hyperthermia

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“…In the present study, the coagulation zone was selected as the central "white zone" of coagulation, which corresponds to the zone of complete ablation alone. [43][44][45] However, it is noted that measuring the white zone could likely underestimate the size of the dead tissue zone. [45] The coagulation zone of the in-vitro experiment was taken as an elliptical area and calculated as follows:…”

Section: The Experimental Set Up and Validation Of Target Control Areasmentioning

confidence: 99%

A new approach to feedback control of radiofrequency ablation systems for large coagulation zones

Zhang

Möser

Zhang

et al. 2016

International Journal of Hyperthermia

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“…al. [18] presented an in vivo study for an RFA assisted liver resection device under ultrasound guidance and found agreement between experimental and simulated lesion shapes. The simulations were subsequently used to predict whether the heat-sink effect can itself protect the portal vein, thereby pointing out the potential of treatment planning approaches in an in-vivo setting.…”

Section: Introductionmentioning

confidence: 73%

Study of flow effects on temperature-controlled radio-frequency ablation using phantom experiments and forward simulations

Nolte

Vaidya

Baragona

et al. 2020

Preprint

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Schinkelstraße 2 23 52062 Aachen 24 Germany 25 nikhil.vaidya@rwth-aachen.de 26 tel. +49 241 8099147 27 28 Additional comments 29 -Teresa Nolte and Nikhil Vaidya contributed equally to this work. 30 -Volkmar Schulz and Karen Veroy contributed equally to this work. 31 -A single reference experiment, i.e., not using a flow channel, and the image in the upper left 32 corner of Figure 4 were included into a publication submitted to Int. J. Hyperthermia for 33 model validation purposes. 34 2 Abstract and keywords 35 Abstract 36Purpose: Blood perfusion is known to add variability to hepatic radiofrequency ablation 37 (RFA) treatment outcomes. Simulation-assisted treatment planning taking into account blood 38 perfusion may solve this problem in the future. Hence, this study aims to study perfusion 39 effects on RFA in a controlled environment and to compare the outcome to a prediction made 40 using finite volume simulations. 41Methods: Ablation zones were induced in tissue-mimicking, thermochromic ablation 42 phantoms with a single flow channel, using a RF generator with needle temperature con-43 trolled power delivery and a monopolar needle electrode. Channel radius and saline flow rate 44 were varied and the impact of saline flow on the ablated cross-sectional area, on a potential 45 occurrence of directional effects as well as on the delivered generator power input was stud-46 ied. Finite-volume simulations reproducing the experimental geometry, flow conditions and 47 49Results: Vessels of different radii affected the ablation result in different manners. For the 50 channel radius of 0.275 mm both the ablated area and energy input reduced with increasing 51 flow rate. For radius 0.9 mm the ablated area reduced with increasing flow rate but the 52 energy input increased. An increasing area and energy input were observed towards larger 53 flow rates for the channel radius of 2.3 mm. Directional effects, i.e., shrinking of the lesion 54 upstream of the needle and an extension thereof downstream, were observed only for the 55 smallest channel radius. The simulations qualitatively confirmed these observations. When 56 using the simulations to make a prediction of ablation outcomes with flow, the mean absolute 57 error between experimental and predicted ablation outcomes was reduced from 23% to 12% 58 as compared to neglecting flow effects. 59 Conclusion: Simulations can improve the prediction of RFA ablation regions in the pres-60 3 ence of various blood flow effects. Our findings therefore underline the potential of simulation-61 assisted, patient-individual RFA treatment planning and guidance for the prediction of RFA 62 outcomes in the presence of blood flow. 63 Keywords 64 temperature controlled radiofrequency ablation, treatment planning, forward simulation, flow 65 effects 66 4 67 Percutaneous thermal ablation techniques can treat both primary and secondary focal liver 68 tumors in a minimally invasive manner [1]. However, radiofrequency ablation (RFA) outcomes 69 in the liver cannot be easily predicted due to th...

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Could the heat sink effect of blood flow inside large vessels protect the vessel wall from thermal damage during RF‐assisted surgical resection?

Cited by 15 publications

References 51 publications

Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation

Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation

A new approach to feedback control of radiofrequency ablation systems for large coagulation zones

Study of flow effects on temperature-controlled radio-frequency ablation using phantom experiments and forward simulations

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