Could the new BA.2.75 sub-variant lead to another COVID-19 wave in the world? – Correspondence

Shaheen, Nour; Mohamed, Abdelrahman; Soliman, Youssef; Abdelwahab, Omar Ahmed; Diab, Rehab Adel; Desouki, Mariam Tarek; Rababah, Ala’ Abdala; Khaity, Abdulrhman; Hefnawy, Mahmoud Tarek; Swed, Sarya; Shaheen, Ahmed; Elfakharany, Bahaa; Shoib, Sheikh

doi:10.1016/j.ijsu.2022.106861

Cited by 19 publications

(25 citation statements)

References 2 publications

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“…At present, Omicron subvariant BA.2.75 is a dominating strain in India that is spreading to other countries. 40 , 41 Therefore, the authorities should implement health safety measures and vaccinate the maximum population as early as possible. Also, they can think about customized vaccines for omicron subvariants.…”

Section: Discussionmentioning

confidence: 99%

The latest Omicron BA.4 and BA.5 lineages are frowning toward COVID‐19 preventive measures: A threat to global public health

Islam

Shahriar

Bhuiyan

2022

Health Science Reports

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BACKGROUND A cluster of pneumonia cases was reported by the Wuhan Municipal Health Commission, China, Hubei Province, resulting in the identification of a novel coronavirus (SARS-CoV-2). 1 As of September 19, 2022, more than 609 million cases and 6.5 million deaths have been recorded worldwide. The highest number of COVID-19 cases have been recorded in Europe, followed by the Americas, Western Pacific, South-East Asia, Eastern Mediterranean, and Africa regions. 2 As a country, the US contributed the highest number of COVID-19 cases and deaths. 2 SARS-CoV-2 is constantly mutating and dodging antibodies to infect more people. Epidemiologists in South Africa detected the fifth and the latest "variant of concern" (VOC) of SARS-CoV-2. They reported this new variant to the World Health Organization (WHO) on November 24, 2021. This fifth VOC of SARS-CoV-2 contains more than 30 mutations in its viral spike proteins to allow it more transmissibility and infection rates. 1 The WHO named this fifth VOC of SARS-CoV-2 as the Omicron variant (B.1.1.529) on November 26, 2021. 2 Omicron became the leading variant in COVID-19 after its inception. At present, Omicron is the only circulating VOC. Initially, Omicron had three subvariants (e.g., BA.1, BA.2, and BA.3). BA.1 was predominant during the fourth wave of the pandemic in South Africa. However, the global pattern was inconsistent in some other countries. BA.2 variant was responsible for hospitalizations and deaths in most cases during the Omicron wave in South Africa. 3 Currently, the Omicron variant includes five lineages and some other descendant subvariants. 4 Omicron subvariants that have rapidly spread across the globe. 5,6 Initially, BA.1 and BA.2 were predominant Omicron subvariant worldwide. However, BA.4 and BA.5 variants are now leading in Europe and the United States. 7 The WHO classified BA.4, BA.5, BA.2.12.1, and BA.2.75 as VOC-subvariants under monitoring. 4 The European Centre for Disease Prevention and Control categorized BA.4 and BA.5 as VOC from VOI on May 12, 2022. 8 Therefore, we recommend prioritized monitoring of epidemiology of the COVID-19 pandemic due to Omicron BA.4 and BA.5 subvariants. This article aims to present an update on Omicron BA.4 and BA.5 subvariants of SARS-CoV-2 and their potential impact on global public health. Scientists detected the BA.4 and BA.5 variants from a sample collected from South Africa in early 2022. 9 BA.4 and BA.5 have similarities with parent variants based on their genotype and phenotype as both are subvariants of Omicron. These subvariants have all mutations that Omicron had. The spike proteins of the latest Omicron BA.4 and BA.5 subvariants are identical and more similar to BA.2 than BA.1. 10 The Omicron BA.4 and BA.5 subvariants fueled a surge of cases in South Africa in the spring despite having widespread pre-existing immunity to the virus. The COVID-19 wave due to BA.4 and BA.5 subvariants was not as high as earlier waves, and deaths did not rise as sharply in South

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Section: Discussionmentioning

confidence: 99%

The latest Omicron BA.4 and BA.5 lineages are frowning toward COVID‐19 preventive measures: A threat to global public health

Islam

Shahriar

Bhuiyan

2022

Health Science Reports

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“…A new BA.2 sub-lineage, BA.2.75, was detected in India during June 2022 and is the first SARS-CoV-2 variant of second generation that is reported to spread outside its original region [ 3 ]. BA.2.75 appears to be more transmissible than other Omicron variants which results in compromised vaccine efficiency [ 7 , 8 ]. In addition to the existing mutations reported in the other Omicron variants [ 5 , 6 ], BA.2.75 contains nine novel mutations in the spike protein.…”

Section: Discussionmentioning

confidence: 99%

“…Two of them, G446S and R493Q, are currently being studied for their pathogenic attributes. The R493Q mutation increases the ability of the spike protein to bind to the human ACE2 receptor, while the G446S mutation affects both immune evasion and ACE2 binding [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

et al. 2022

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We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.

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“…38,39 BA.2.75 has been dominant in many regions worldwide lately, acquiring more rise in its alpha helices' number than BA.2, which enables it to escape immunity. 40,41 Although a small rise in hospitalization and mortality rates was seen in South Africa, outside it, a more rise in both mortality and hospitalization rates was witnessed. 25 A mild degree of effectiveness, as there was seven folds drop in the neutralizing antibodies produced against both BA.4…”

Section: Ba275mentioning

confidence: 99%

“…38 , 39 BA.2.75 has been dominant in many regions worldwide lately, acquiring more rise in its alpha helices’ number than BA.2, which enables it to escape immunity. 40 , 41 …”

Section: Introductionmentioning

confidence: 99%

Could the New BA.2.75 Sub-Variant Cause the Emergence of a Global Epidemic of COVID-19? A Scoping Review

Shaheen¹,

Mohamed²,

Attalla³

et al. 2022

IDR

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With over 58 million cases and 6 million deaths by August 2022, the Coronavirus disease 2019 (COVID-19), causing severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2), has had an insurmountable impact on the world’s population. This is one of the worst health crises since 1918’s influenza pandemic. There are four subvariants of Omicron; BA.1, BA.1.1, BA.2 and BA.3. As a result of new mutations in its spike protein, most of which occur in its receptor binding site, the Omicron variant appears to be more transmissible and less resistant to vaccination and antibody response. Understanding Omicron’s virology and mutations is essential to developing diagnostic and therapeutic methods. A thorough assessment of control measures, as well as timely adjustment of control measures, requires addressing such issues as re-infection risk, vaccine response, booster vaccine doses, and the increased rate of Omicron infections. This review article aims to look at the current information about the different types of SARs-CoV-2, focusing on the new subtype BA.2.75.

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Could the new BA.2.75 sub-variant lead to another COVID-19 wave in the world? – Correspondence

Cited by 19 publications

References 2 publications

The latest Omicron BA.4 and BA.5 lineages are frowning toward COVID‐19 preventive measures: A threat to global public health

The latest Omicron BA.4 and BA.5 lineages are frowning toward COVID‐19 preventive measures: A threat to global public health

Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

Could the New BA.2.75 Sub-Variant Cause the Emergence of a Global Epidemic of COVID-19? A Scoping Review

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