Coumarin: A Valid Scaffold in Medicinal Chemistry

A full-control design can significantly improve drug release and cell proliferation for tissue engineering applications in medicine. The present investigation encompassed a molecular docking study which was performed to investigate the interaction of selected active ligand (coumarin) with the L929 mouse fibroblast cell line protein as the receptor. After that, the coumarin was extracted from the roots of p.ferulacea and its subsequent nanoencapsulation with polycaprolactone, employing the coacervation technique to achieve a narrow distribution of nano particle sizes. Subsequently, the electrospinning technique was utilized to apply a second coating to the nano-encapsulated coumarin. Polyvinyl alcohol and gelatin compounds were used to produce electrospun nanofibrous scaffolds for their similarity to the extracellular matrix (ECM). This coordinated nano platform aimed to assess its effectiveness in regulating drug release, evaluate its biocompatibility, and examine its impact on L929 cell proliferation according to the Lag and Log phases of their growth. In silico analyses demonstrated significant interactions and high binding energy values between the coumarin ligand and essential residues of the L929 mouse fibroblast proteins. The results of the experiments were checked using analyses of 1H NMR, FTIR, UV, SEM, mechanical properties, DSC, HRTEM, and HPLC. The biological effects and cell proliferation were conducted employing the MTT method (up to 5 days). Notably, no cytotoxicity was detected throughout the assessment. In this way, it is feasible to create a synergistic nano delivery system by delaying the release of the drug into account the timing of distinct cell lines' development phases.

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Survey Based Assessment of Adverse Effect in Covid-19 Vaccination Breakthrough Infections

Fakir,

R. Surana,

M. Patil

et al. 2023

AJPS

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Background: Millions of individuals worldwide have been impacted by COVID-19, which has put a tremendous strain on global economies and healthcare systems. Vaccines are the only way to stop this pandemic, unfortunately. The COVID-19 vaccines were developed more swiftly than previous immunizations and have received global Emergency Use Authorization (EUA) approval. Therefore, our goal was to assess any short-term negative consequences following vaccination. The purpose of this study is to determine the negative effects linked to three different COVID-19 vaccination types. The questionnaire asked questions on COVID-19 infection and the adverse effects of the COVID-19 vaccine after receiving the first, second, or booster dose. Method: With the help of questionnaires from different districts, a cross-sectional study was done. We made the questionnaire and used it to find out things like which side effects happen most often after the first, second, and booster doses of a vaccine. We also find out how many people get the Corona virus after getting the vaccine. Result: People often experience bad side effects like fever, nausea, diarrhoea, weakness, headache, chills with shivering, pain at the injection site, loss of appetite, and weight loss. Even though many people don't have any problems after getting a vaccine, Most of the time, we found that only 4% of people who got the vaccine got the Corona virus. Conclusion: As more people get sick after getting the Covishield vaccine, it may not work as well as the Covaxin and Sputnik V vaccines.

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Coumarin: A Valid Scaffold in Medicinal Chemistry

Cited by 4 publications

References 61 publications

Design a Coordinated Nano-Platform for Coumarin-Regulated Delivery in Line with the Biological Systems’ Growth Phases

Design a Coordinated Nano-Platform for Coumarin-Regulated Delivery in Line with the Biological Systems’ Growth Phases

Design a coordinated platform for coumarin-regulated delivery in line with the biological systems' growth phases

Survey Based Assessment of Adverse Effect in Covid-19 Vaccination Breakthrough Infections

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