Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds

Wang, Hang; Dai, Bona; Liu, Bin; Han, Lu

doi:10.1016/j.aca.2015.04.050

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…His group discovered that 1-(2,4,6-trihydroxyphenyl)octan-1-one (alkylated trihydroxyacetophenone (ATHAP)) is an excellent matrix for the analysis of hydrophobic membrane proteins containing transmembrane domains. Five coumarins were used as MALDI matrixes and compared to traditional matrixes for the ionization of several hydrophobic analytes with low ionization efficiency by Wang and colleagues . One coumarin in particular, 6,7-dihydroxycoumarin-3-carboxylic acid (DCA), was found to be notably effective.…”

Section: Traditional Ionization Methods For Msmentioning

confidence: 99%

Advances in Ionization for Mass Spectrometry

Peacock¹,

Zhang

Trimpin

2016

Anal. Chem.

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Section: Traditional Ionization Methods For Msmentioning

confidence: 99%

Advances in Ionization for Mass Spectrometry

Peacock¹,

Zhang

Trimpin

2016

Anal. Chem.

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“…Indeed, the ligand exhibits a highly conjugated double-bond struc-ture typically observed in the organic acids regularly used as a MALDI matrix. Literature data report the use of coumarins as a matrix for MALDI-MS analysis of DNA [37] and hydrophobic compounds, as steroids and sterols, by MALDI-FT ICR MS in positive-ion mode [38]. Therefore, it was interesting to explore the ionization efficiency and behaviour of the ligand with the aim of studying its chelating capabilities in more detail.…”

Section: Mass Spectrometry Analysismentioning

confidence: 99%

Insights on Stability Constants and Structures of Complexes between Coumarin Derivatives and Pb(II) in Aqueous Media

Furia,

Lettera,

Napoli

et al. 2024

Molecules

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In the frame of a systematic study on the sequestering ability of natural antioxidants towards metal cations, here the complexation of coumarin-3-carboxilic acid (HCCA) with Pb(II) and the overall stability constants of the resulting complexes, at 37 °C and in 0.16 M NaClO4, are discussed. Reaction of Pb(ClO4)2 with HCCA in an aqueous medium at a pH range from 2 to 6 and various ratios (1:1–1:10) yielded the Pb–CCA complexes, which were characterized spectrometrically by laser desorption ionization mass spectrometry (LD-MS). LD-MS has provided the composition and structure of Pb–CCA species according to the speciation model proposed on the basis of the potentiometric data. The graphic representation of the complex’s concentration curves is given by the distribution diagram, which provides a whole depiction of the species present in the solution at the selected pH ranges.

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“…In addition, coumarins and their derivatives are an important class of natural and synthetic heterocyclic compounds with vital pharmacological and material application properties including anti-inflammatory [21], antileishmanial [22], steroid hydroxylase [23], MALDI-FT ICR MS detection of hydrophobic compounds [24], stokes shift calculation [25], anti HIV [26,27], solid state dye lasers [28], fluorescent chemosensor [29], antitumor agents [30,31],…”

Section: Introductionmentioning

confidence: 99%