Counteracting Radio-Resistance Using the Optimization of Radiotherapy

Chevalier, François

doi:10.3390/ijms21051767

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…Radiotherapy is an effective treatment for unresectable lung cancer [ 14 ] that plays an important role in the clinical management of lung cancer patients. However, not all patients can benefit from radiotherapy because of cancer cell resistance [ 15 ]. In our study, significant OS outcome differences were observed between different GCNT3 expression groups after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy prognosis-associated gene GCNT3 promotes the proliferation, migration and invasion of lung adenocarcinoma cells

Zhao

Qian

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

Radiotherapy prognosis-associated gene GCNT3 promotes the proliferation, migration and invasion of lung adenocarcinoma cells

Zhao

Qian

et al. 2022

Heliyon

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“…For example, radio-resistance inherent in various cancers (e.g., CRC and lung cancer) leads to poor response of multiple malignant patients initially. [117][118][119][120][121] Besides, owing to physical barriers, such as BBB, major therapeutic molecules fail to exert antitumor effects with irradiation spontaneously in GBM. 122,123 Given the above limitation, it is time for engineered exosomes to make their way into history.…”

Section: Radiotherapymentioning

confidence: 99%

Engineered exosomes from different sources for cancer-targeted therapy

Zhang

Liu

et al. 2023

Sig Transduct Target Ther

129

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Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules. After appropriate modification, engineered exosomes are able to deliver antitumor drugs to tumor sites efficiently and precisely with fewer treatment-related adverse effects. However, there still exist many challenges for the clinical translation of engineered exosomes. For instance, what sources and modification strategies could endow exosomes with the most efficient antitumor activity is still poorly understood. Additionally, how to choose appropriately engineered exosomes in different antitumor therapies is another unresolved problem. In this review, we summarized the characteristics of engineered exosomes, especially the spatial and temporal properties. Additionally, we concluded the recent advances in engineered exosomes in the cancer fields, including the sources, isolation technologies, modification strategies, and labeling and imaging methods of engineered exosomes. Furthermore, the applications of engineered exosomes in different antitumor therapies were summarized, such as photodynamic therapy, gene therapy, and immunotherapy. Consequently, the above provides the cancer researchers in this community with the latest ideas on engineered exosome modification and new direction of new drug development, which is prospective to accelerate the clinical translation of engineered exosomes for cancer-targeted therapy.

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“…Radiotherapy is an effective method of cancer treatment, but the resistance and side effects of radiation therapy affect its efficacy. Therefore, sensitizers that kill tumor cells improve the efficacy of radiotherapy ( Chevalier 2020 ). Tan IIA combined with irradiation reduces histone H3 (S10) phosphorylation in ionizing radiation-resistant cell lines (CAL27-IR and SCC25-IR cells), and this combination enhances irradiation-induced DNA damage and promotes apoptosis, thereby inhibiting tumor growth in vivo and in vitro ( Li et al, 2021 ).…”

Section: Future Prospectsmentioning

confidence: 99%

Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes

Lan

et al. 2022

Front. Pharmacol.

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MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progression of a variety of diseases, including cancer, by affecting cell growth, proliferation, differentiation, migration, and apoptosis. Preparations from the dried root and rhizome of Salvia miltiorrhiza Bge (Lamiaceae), also known as red sage or danshen, are widely used for treating cardiovascular diseases. Accumulating data suggest that certain bioactive constituents of this plant, particularly tanshinones, have broad antitumor effects by interfering with microRNAs and epigenetic enzymes. This paper reviews the evidence for the antineoplastic activities of S. miltiorrhiza constituents by causing or promoting cell cycle arrest, apoptosis, autophagy, epithelial-mesenchymal transition, angiogenesis, and epigenetic changes to provide an outlook on their future roles in the treatment of cancer, both alone and in combination with other modalities.

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Counteracting Radio-Resistance Using the Optimization of Radiotherapy

Abstract: Radiotherapy is an essential component of cancer therapy and remains one of the most (cost-) effective treatment options available [...]

Cited by 6 publications

References 5 publications

Radiotherapy prognosis-associated gene GCNT3 promotes the proliferation, migration and invasion of lung adenocarcinoma cells

Radiotherapy prognosis-associated gene GCNT3 promotes the proliferation, migration and invasion of lung adenocarcinoma cells

Engineered exosomes from different sources for cancer-targeted therapy

Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes

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