Coupling microdialysis with flow-injection chemiluminescence detection for a protein–drug interaction study

Chemiluminescence determination of cefotaxime sodium with flow-injection analysis of cerium (IV)–rhodamine 6G system and its application to the binding study of cefotaxime sodium to protein with on-line microdialysis sampling

“…Moreover, microdialysis sampling has many advantages such as a simple operation, time saving, no sample loss, less required quantity of drug, not shifting the equilibrium between bound and unbound drug, and capability of easy connection to analytical instruments. As an alternative to it, our laboratory [16,17] proposed an on-line sampling method coupling microdialysis with detector system by FIA. This method minimizes the delay between sample collection and analysis and eliminates the problems of evaporation that can occur during any physical manipulation of small volume samples.…”

Characterization of interaction between doxycycline and human serum albumin by capillary electrophoresis‐frontal analysis

“…Several methods have been applied to drug-proteinbinding studies, including equilibrium dialysis [5][6][7], ultrafiltration [6,7], ultracentrifugation [6], gel filtration [6], microdialysis [8], circular dichroism [9], fluorescence spectrometry [10], HPLC, especially high-performance frontal analysis (FA) [11] and high-performance affinity chromatography [12,13], and CE-based methods [9,14]. CE is the most recently developed technique for drug-protein-binding studies.…”

Determination of free cholesterol based on a novel flow‐injection chemiluminescence method by immobilizing enzyme

“…The CL method has been applied in analytical chemistry because of its prominent advantagesm, such as high sensitivity, low detection limits, wider linear range and simple instrumentation (36,37). The luminol-H 2 O 2 -metal ions or HRP CL systems have been used to assay H 2 O 2 and other compounds that produce H 2 O 2 in coupled reactions.…”