2021
DOI: 10.1021/jacsau.1c00048
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Cov-MS: A Community-Based Template Assay for Mass-Spectrometry-Based Protein Detection in SARS-CoV-2 Patients

Abstract: Rising population density and global mobility are among the reasons why pathogens such as SARS-CoV-2, the virus that causes COVID-19, spread so rapidly across the globe. The policy response to such pandemics will always have to include accurate monitoring of the spread, as this provides one of the few alternatives to total lockdown. However, COVID-19 diagnosis is currently performed almost exclusively by reverse transcription polymerase chain reaction (RT-PCR). Although this is efficient, automatable, and acce… Show more

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Cited by 37 publications
(84 citation statements)
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“…Improving our sample preparation protocol included sample collection, sample homogeneity, sample concentration, and sample preparation times. In principle, nasopharyngeal swabs, gargle solutions, and saliva are suited to detect SARS-CoV-2 [ 5 , 11 13 ]. A number of challenges regarding non-MS-compatible contaminations have been reported for swab samples [ 11 ], where the sample volume is usually less than 10 μL.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Improving our sample preparation protocol included sample collection, sample homogeneity, sample concentration, and sample preparation times. In principle, nasopharyngeal swabs, gargle solutions, and saliva are suited to detect SARS-CoV-2 [ 5 , 11 13 ]. A number of challenges regarding non-MS-compatible contaminations have been reported for swab samples [ 11 ], where the sample volume is usually less than 10 μL.…”
Section: Resultsmentioning
confidence: 99%
“…In principle, nasopharyngeal swabs, gargle solutions, and saliva are suited to detect SARS-CoV-2 [ 5 , 11 13 ]. A number of challenges regarding non-MS-compatible contaminations have been reported for swab samples [ 11 ], where the sample volume is usually less than 10 μL. Additionally, the quantitative reproducibility of swab sample collection is a matter of debate [ 13 ], making gargle solutions a true alternative for sample collection instead of the commonly used nasopharyngeal swab samples.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The advances afforded will be well worth the effort required. Validating this type of methodology on medical samples from large cohorts is the primary objective in the field [10]. Based on the SARS-CoV-2 detection demonstration proposed by Renuse et al [1].…”
mentioning
confidence: 99%