Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

Sun, Qiaoqiao; Tang, Kun; Song, Liqun; Li, Yanhua; Pan, Wei; Li, Na; Tang, Bo

doi:10.1039/d1bm01245b

Cited by 35 publications

(30 citation statements)

References 34 publications

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Section: Cofs Used For Photothermal Therapy (Ptt)mentioning

confidence: 99%

“…Reproduced with permission from ref. [39]. Copyright 2021, Royal Society of Chemistry; and (c) Synthesis process of GA@PCOF@PDA nanocomposite; Therapeutic principle of multifunctional COFs-based nanocomposites for low-temperature synergistic oncotherapy [40].…”

Section: Cofs Used For Photothermal Therapy (Ptt)mentioning

confidence: 99%

“…In vivo experiments demonstrate that tumor growth is significantly inhibited after COF-GA treatment. Mild photothermal therapy exhibits excellent antitumor efficacy at relatively low temperatures and minimizes nonspecific thermal damage to normal tissues [39].…”

Section: Cofs Used For Photothermal Therapy (Ptt)mentioning

confidence: 99%

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Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

Gao¹

2023

Covalent Organic Frameworks

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Covalent organic frameworks (COFs) are emerging organic crystalline polymer materials, which are formed by reversible condensation reactions between lightweight molecular fragments. They have excellent properties such as low density, good porosity and crystallinity, and high thermal stability. These materials are biodegradable due to the reversible condensation process between the monomers. Compared with another widely studied material with metal-organic frameworks, COFs have no additional toxicity caused by introducing metal ions. Therefore, a high potential exists in biomedicine. The chapter aimed to introduce the application of biomaterial COFs in oncotherapy and identify the specific advantages of different types of COFs for specific biomedical applications.

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Section: Cofs Used For Photothermal Therapy (Ptt)mentioning

confidence: 99%

Section: Cofs Used For Photothermal Therapy (Ptt)mentioning

confidence: 99%

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Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

Gao¹

2023

Covalent Organic Frameworks

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“…However, normal tissues can be damaged by excessive temperatures. [8][9][10] Actually, once the temperature exceeds 42 1C, cells can undergo irreversible necrosis. So mild-temperature photothermal therapy, i.e., one generating a temperature of less than 45 1C, is expected to have increasingly greater practicability in the clinic.…”

mentioning

confidence: 99%

“…However, normal tissues can be damaged by excessive temperatures. 8–10 Actually, once the temperature exceeds 42 °C, cells can undergo irreversible necrosis. So mild-temperature photothermal therapy, i.e.…”

mentioning

confidence: 99%

A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow

Zhang

Huang

et al. 2022

Chem. Commun.

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Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy

Yang

Liu

et al. 2022

Adv Funct Materials

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Photothermal therapy (PTT) holds potential as an alternative approach for effective cancer treatment since it exerts minimal side effects on normal tissues. However, the photothermal stimulation increases the expression of heat shock protein (HSP) in tumor cells, rendering the tumor cells insensitive to heat and thus constraining the effects of PTT. In this study, biomimetic aggregation‐induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) are developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. Notably, the inner nanoaggregate (BPBBT dots) holds bright second‐window near infrared (NIR‐II) fluorescence (quantum yield of up to 3.47%) and a high photothermal conversion performance (photothermal conversion efficiency of up to 30.5%), and the outer cell membrane can facilitate the hitchhiking of DC@BPBBT dots on endogenous T cells and enhance the tumor delivery efficiency by about 1.2 times. Furthermore, DC@BPBBT dots can activate and stimulate T cells in vivo to secrete cytokine tumor necrosis factor α (TNF‐α), which can reduce the expression of heat shock protein 70 (HSP70) to render tumor cells more sensitive to heat. This study not only provides an alternative heat shock protein inhibition strategy based on immune cell interactions but also provides a hitchhike approach for drug delivery in cancer photothermal immunotherapy.

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Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

Abstract: Photothermal therapy effectively ablate tumor by the hyperthermia (>50 °C), which was caused by laser irradiation. However, the hyperthermia may inevitably diffuse to the surrounding healthy tissues and induce additional...

Cited by 35 publications

References 34 publications

Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow

Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy

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