Covalent Organic Frameworks-TpPa-1 as an Emerging Platform for Electrochemical Sensing

Abstract

Covalent organic frameworks (COFs) are a new type of metal-free porous architecture with a well-designed pore structure and high stability. Here an efficient electrochemical sensing platform was demonstrated based on COFs TpPa-1 constructed by 1,3,5-triformylphloroglucinol (Tp) with p-phenylenediamine (Pa-1), which possesses abundant nitrogen and oxo-functionalities. COFs TpPa-1 exhibited good water dispersibility and strong adsorption affinities for Pd2+ and thus was used as loading support to modify Pd2+. The Pd2+-modified COFs TpPa-1 electrode (Pd2+/COFs) showed high electrocatalytic activity for both hydrazine oxidation reaction and nitrophenol reduction reaction. In addition, TpPa-1-derived nitrogen-doped carbon presented high activity for the electro-oxidation of reduced glutathione (GSH), and sensitive electrochemical detection of GSH was achieved. The presented COFs TpPa-1 can be utilized as a precursor as well as support for anchoring electro-active molecules and nanoparticles, which will be useful for electrochemical sensing and electrocatalysis.

Recent Progress of Covalent Organic Frameworks Applied in Electrochemical Sensors

“…Yuan and co-workers prepared an electrochemical sensor for detection of reduced glutathione (GSH) based on TpPa-1-derived nitrogen-doped carbon. The prepared sensor showed the linear response range of 5.0 μM to 1.2 mM and 1.2–6.4 mM, the LOD was calculated to be 2 μM for GSH determination . Wang and co-workers synthesized a series metalloporphyrin COFs (MPor-COF-366) with different metal atoms.…”

“…The prepared sensor showed the linear response range of 5.0 μM to 1.2 mM and 1.2−6.4 mM, the LOD was calculated to be 2 μM for GSH determination. 165 Wang and co-workers synthesized a series metalloporphyrin COFs (MPor-COF-366) with different metal atoms. The MPor-COF-366/GCE was employed to determine butylated hydroxy anisole (BHA) by using the DPV method.…”

Defects and Disorder in Covalent Organic Frameworks for Advanced Applications

“…As a result, a β‐ketoenamine COF was yielded, that according to the authors, possess at its structure abundant nitrogen and oxo‐functionalities. [ 181 ] The authors of this report considered those groups as defects able to more efficiently bind their analytes: hydrazine, phenols and glutation. They also acknowledged that the edge‐plane‐like sites within their material serve as active sites for electrochemical activity.…”

2D Phthalocyanine-Assembled Porous Nanostructure-Based Electrochemical Platform for High-Efficiency Detection of Ascorbic Acid

“…Meanwhile, in recent years, two-dimensional (2D) porous materials represented by graphene have attracted wide interest due to their unique structure and excellent properties. − Combined with the advantages of the two-dimensional plane and porous structure, the synthesized 2D porous materials have a large surface area and high electronic conductivity, which result in great application potential in electrochemical sensing. − Although a variety of 2D porous materials including conjugated microporous polymers (CMPs) and covalent organic frameworks (COFs) have been developed for electrochemical detection, − 2D supramolecular assemblies with porous structures have rarely been constructed and used as active materials of the electrode.…”