Cover Feature: Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH⋅⋅⋅Se Hydrogen Bond through Stabilization of the Mixed Se−S Intermediate (Chem. Eur. J. 55/2019)

Abstract

A model study using synthetic selenenyl sulfides revealed that the basic His472 would accelerate the reduction of the Se−S bond in the catalytic cycle of thioredoxin reductase (TrxR). More information can be found in the Full Paper by G. Mugesh, M. Iwaoka, et al. on page 12751.