Cover Image, Volume 232, Number 1, January 2017

Zingiryan, Areg; Farina, Nicholas H.; Finstad, Kristiaan H.; Stein, Janet L.; Lian, Jane B.; Stein, Gary S.

doi:10.1002/jcp.25570

Cited by 1 publication

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“…A total of 94 samples were selected for further RNAseq analysis, including 20 normal prostatic lobes as well as PIN and tumours from both mouse models (Table EV1). In contrast to a recent publication reporting that high-quality RNA can only be obtained from the lateral and ventral lobes (Zingiryan et al, 2017), we were able to obtain RNA with sufficient RNA quality from all lobes (Table EV1).…”

Section: Generation Of Genome-wide Expression Data Representing Diffe...contrasting

confidence: 90%

Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

Jurmeister¹,

Ramos-Montoya²,

Sandi³

et al. 2018

EMBO Mol Med

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Genetically engineered mouse models of cancer can be used to filter genome‐wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development and progression. In this study, we have generated RNAseq data from tumours arising in two established mouse models of prostate cancer, PB‐Cre/PtenloxP/loxP and p53loxP/lox PRbloxP/loxP, and integrated this with published human prostate cancer expression data to pinpoint cancer‐associated gene expression changes that are conserved between the two species. To identify potential therapeutic targets, we then filtered this information for genes that are either known or predicted to be druggable. Using this approach, we revealed a functional role for the kinase MELK as a driver and potential therapeutic target in prostate cancer. We found that MELK expression was required for cell survival, affected the expression of genes associated with prostate cancer progression and was associated with biochemical recurrence.

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Section: Generation Of Genome-wide Expression Data Representing Diffe...contrasting

confidence: 90%

Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

Jurmeister¹,

Ramos-Montoya²,

Sandi³

et al. 2018

EMBO Mol Med

View full text Add to dashboard Cite

show abstract

Cover Image, Volume 232, Number 1, January 2017

Abstract: Cover: The cover image, by Areg Zingiryan et al., is based on the From the Bench Paper Dissection of Individual Prostate Lobes in Mouse Models of Prostate Cancer to Obtain High Quality RNA, DOI: .

Cited by 1 publication

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Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

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