Cover Image, Volume 79, Issue 3

Abstract

The cover image, by Melany Puglisi et al., is based on the Research Article Novel primary amine diazeniumdiolates: chemical and biological characterization, DOI: .

Progress and Prospects of Regulatory Functions Mediated by Nitric Oxide on Immunity and Immunotherapy

“…[ 111] Nitroglycerin 3 min [ 112] Isosorbide dinitrate 29 min [ 113] 5-isosorbide mononitrate 7.6 h [ 113] Pentaerythritol tetranitrate 8 h [ 114] Nicorandil 0.7-1.2 h [ 115] Latanoprostene bunod 1.8 h in cornea (rabbit) [ 116] N-diazeniumdiolates Per mole of NONOate spontaneously releases two moles of NO under physiological conditions (GSH or GST), and the release rate is accelerated with the decrease of pH. [85] JS-K 2.8 min [ 117] DETA/NONOate 20 h [ 118] Furoxans Furoxans are attacked by free sulfhydryl or sulfhydryl anion at positions 3 or 4 of the furoxan ring, and then dearomatization occurs to release NO. [90] Furoxans-1 N/A M-NO complex The release of NO in M-NO complex depends on specific enzymes, temperature, pH value, or light, but most of them are not specific.…”

“…One mole of N-diazeniumdiolates can spontaneously release two moles of NO under physiological conditions. [85] The biological half-life of these compounds can be adjusted by the modification of substituents (several minutes to tens of hours), and N-diazeniumdiolates bound with specific groups can release quantitative NO at target sites. [86] Therefore, N-diazeniumdiolates are particularly suitable for conjugating specific vectors to prepare the targeted release of NO donor drugs.…”