COVID-19 and Mesenchymal Stem Cell Treatment; Mystery or Not

Akkoç, Tunç

doi:10.1007/5584_2020_557

Cited by 12 publications

(9 citation statements)

References 51 publications

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“…Besides S protein, enetically SARS-CoV-2 is constructed on structural proteins of membrane (M), envelope (E), and nucleocapsid (N) proteins. Spread of the virus is managed by the high affinity of S proteins to ACE2 receptors that are expressed in human organs, principally in lung alveolar epithelial cells and enterocytes of the small intestine [11,12].…”

Section: Sars-cov-2 Infection: What To Focus 21 Sars-cov-2 Virusmentioning

confidence: 99%

Cellular Therapy as Promising Choice of Treatment for COVID-19

Irmak¹,

Karaöz²

2022

Biotechnology to Combat COVID-19

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In the pandemic of COVID-19, while living normals have been changing, there have been a huge effort globally to find out effective and safe treatment agents and vaccines. As of now, the advances show the progress in vaccine development, however the treatment of the COVID-19 is yet not fully specified. The drugs, i.e. antibiotics, antivirals, antimalarians, even anti-HIV agents which have been known already were taken out of the shelves and brought into use in different combinations. On the other hand, the cellular treatment, more specifically the mesenchymal stem cell therapy has been encouraged, resulting in various evidence published all over the world. This chapter aims to compile the published information, in means of methods, disease manifestations, results and limitations, about the stem cell treatment of the COVID-19 and to provide a source of harmonized reference for scientific society.

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Section: Sars-cov-2 Infection: What To Focus 21 Sars-cov-2 Virusmentioning

confidence: 99%

Cellular Therapy as Promising Choice of Treatment for COVID-19

Irmak¹,

Karaöz²

2022

Biotechnology to Combat COVID-19

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“…Following modulating the immune response within the lung, they instigate the regeneration of the injured tissues through reversing lung dysfunction and halting pulmonary fibrosis [ 22 ]. These dual beneficial therapeutic mechanisms paved MSCs’ way into multiple clinical studies on COVID-19 therapy [ 23 ].…”

Section: Main Textmentioning

confidence: 99%

MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak

et al. 2021

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Background The onset of the SARS-CoV-2 pandemic has resulted in ever-increasing casualties worldwide, and after 15 months, standard therapeutic regimens are yet to be discovered. Main body Due to the regenerative and immunomodulatory function of MSCs, they can serve as a suitable therapeutic option in alleviating major COVID-19 complications like acute respiratory distress syndrome. However, the superior properties of their cognate exosomes as a cell-free product make them preferable in the clinic. Herein, we discuss the current clinical status of these novel therapeutic strategies in COVID-19 treatment. We then delve into the potential of interfering RNAs incorporation as COVID-19 gene therapy and introduce targets involved in SARS-CoV-2 pathogenesis. Further, we present miRNAs and siRNAs candidates with promising results in targeting the mentioned targets. Conclusion Finally, we present a therapeutic platform of mesenchymal stem cell-derived exosomes equipped with exogenous iRNAs, that can be employed as a novel therapeutic modality in COVID-19 management aiming to prevent further viral spread within the lung, hinder the virus life cycle and pathogenesis such as immune suppression, and ultimately, enhance the antiviral immune response.

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“…MSCs can be more advantageous than other anti-inflammatory agents, because they can provide immunomodulatory effects based on the host cells. In addition to these effects, MSCs can prevent fibrosis of tissues, enable reversal of lung dysfunction, and aid in the regeneration of damaged tissue, which can be significantly beneficial for COVID-19-associated organ damage (98,99). Because the healing properties of the MSCs can be primarily attributed to the secretomes or exosomes, using them may be more effective than using MSCs themselves.…”

Section: Future Directionsmentioning

confidence: 99%

Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment

et al. 2020

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The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSC-Exos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. [BMB Reports 2020; 53(8): 400-412]

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COVID-19 and Mesenchymal Stem Cell Treatment; Mystery or Not

Cited by 12 publications

References 51 publications

Cellular Therapy as Promising Choice of Treatment for COVID-19

Cellular Therapy as Promising Choice of Treatment for COVID-19

MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak

Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment

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