COVID-19 epidemic in the US—A gateway to screen for tuberculosis, HIV, viral hepatitides, Chagas disease, and other neglected tropical diseases among Hispanics

Schultz, Jonathan; Hyson, Peter; Chastain, Daniel B; Gharamti, Amal; Franco‐Paredes, Carlos; Henao‐Martínez, Andrés F.

doi:10.1371/journal.pntd.0008953

Cited by 15 publications

(11 citation statements)

References 19 publications

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“…Most of our literature findings also warned about the impact of COVID-19 pandemic over the diagnosis, healthcare, drug supply, and even research about patients affected by any or both other two infections [ 102 ]. The current pandemic could lead to an amplification of the existing health inequities, especially concerning already marginalized communities, racial/ethnic minorities, women, and children [ 103 , 104 , 105 , 106 ]. The most dramatic influence would obviously be observed in low- and middle-income countries, already ravaged by TB and HIV epidemics [ 33 , 34 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

González-Domenech

Pérez-Hernández²,

Gómez-Ayerbe

et al. 2021

Viruses

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By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The concurrence of this new pandemic in regions where human immunodeficiency virus (HIV) and tuberculosis (TB) infections possess the same epidemiological consideration, has arisen concerns about the prognosis, clinical management, symptomatology, and treatment of patients with triple infection. At the same time, healthcare services previously devoted to diagnosis and treatment of TB and HIV are being jeopardized by the urgent need of resources and attention for COVID-19 patients. The aim of this review was to collect any article considering the three conditions (HIV, TB, and SARS-CoV-2), included in PubMed/Medline and published in the English language since the beginning of the COVID-19 pandemic. We focused on detailed descriptions of the unusual cases describing the three co-infections. Eighty-four out of 184 publications retrieved met our inclusion criteria, but only three of them reported cases (five in total) with the three concomitant infections. The clinical evolution, management, and therapy of all of them were not different from mild/severe cases with exclusive COVID-19; the outcome was not worse either, with recovery for the five patients. Cases of patients with COVID-19 besides HIV and TB infections are scarce in literature, but studies deliberately embracing the triple infection as a priori inclusion criterion should be carried out in order to provide a complete understanding of joint influence.

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Section: Resultsmentioning

confidence: 99%

A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

González-Domenech

Pérez-Hernández²,

Gómez-Ayerbe

et al. 2021

Viruses

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“…The current COVID-19 crisis represents an opportunity to screen groups for NTDs, including Chagas, as populations at-risk are being disproportionately affected by COVID-19. Many such individuals are being brought in contact with the healthcare system for the first time [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital—Clinical Features of Patients with Positive Screening Serologic Testing

et al. 2021

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Chagas disease (CD) is the third most common parasitic infection globally and can cause cardiac and gastrointestinal complications. Around 300,000 carriers of CD live in the U.S., with about 3000 of those in Colorado. We described our experience in diagnosing CD at a Colorado teaching hospital to revise screening eligibility criteria. From 2006 to 2020, we reviewed Trypanosoma cruzi (TC) IgG serology results for 1156 patients in our institution. We identified 23 patients (1.99%) who had a positive test. A total of 14/23 (60%) of positive serologies never had confirmatory testing, and 7 of them were lost to follow up. Confirmatory testing, performed in 9 patients, resulted in being positive in 3. One additional case of CD was identified by positive tissue pathology. All four confirmed cases were among patients born in Latin America. While most of the testing for CD at our institution is part of the pretransplant screening, no confirmed cases of CD derived from this strategy. Exposure risk in this population is not always documented, and initial positive results from screening are not always confirmed. The lack of standardized screening protocols for CD in our institution contributes to underdiagnosis locally and in health systems nationwide. Given a large number of individuals in the U.S. with chronic CD, improved screening is warranted.

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“…En caso de confirmarse el diagnóstico de infección por el agente de la enfermedad de Chagas, mediante un test positivo, pero en ausencia de enfermedad clínica o complicación adicional, la vulnerabilidad a la infección por SARS-CoV-2/ COVID-19 o sus complicaciones parece ser igual que el de la población en general, sin embargo, cuando se presentan complicaciones cardíacas, hay antecedente de hipertensión arterial, diabetes mellitus o en presencia de estados de inmunosupresión asociados, el riesgo de presentar formas severas de infección por SARS-CoV-2/COVID-19 se asemeja al de otras poblaciones con más riesgo [135][136][137][145][146][147] .…”

Section: Fuerte a Favor ¿Se Debe Considerar A La Enfermedad De Chagas...unclassified

“…En dichas circunstancias y en presencia de sintomatología atribuible a infección por SARS-CoV-2/COVID-19 al igual que en cualquier otro paciente será necesario seguir lo lineamientos vigentes acerca de la realización de pruebas para diagnóstico de esta infección, teniendo en cuenta que los síntomas de fiebre, tos o dolor de garganta no significan forzosamente que se haya contraído la infección por SARS-CoV-2/COVID-19. Estos síntomas son frecuentes en otras enfermedades virales comunes 147 .…”

Section: Fuerte a Favor ¿Se Debe Considerar A La Enfermedad De Chagas...unclassified

SECCION II. Definiciones operativas de casos de infección por SARS-CoV-2/COVID-19

Trujillo

2021

Infect

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COVID-19 epidemic in the US—A gateway to screen for tuberculosis, HIV, viral hepatitides, Chagas disease, and other neglected tropical diseases among Hispanics

Cited by 15 publications

References 19 publications

A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital—Clinical Features of Patients with Positive Screening Serologic Testing

SECCION II. Definiciones operativas de casos de infección por SARS-CoV-2/COVID-19

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