Covid-19 Infection Complicated by Guillain-Barré Syndrome: A Case Report

Bueso, Tulio; Elmassry, Mohamed; Nawaa, S. E. N. El; Ball, Stephen; Solis, Ximena; Test, Victor

doi:10.1016/j.chest.2020.08.496

Cited by 5 publications

(2 citation statements)

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“…Zhao and coworkers reported the first case of GBS in a 61-year-old COVID-19-positive woman [180]. After this, several cases of GBS in COVID-19 patients have been documented around the world [9,23]. The clinically presenting features of GBS in COVID-19 patients included acute symmetric flaccid, quadriparesis, facial paralysis, lower-limb weakness, ataxia, paresthesia, and distal weakness [9].…”

Section: Pns Manifestationsmentioning

confidence: 99%

Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic

et al. 2021

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The unremitting coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marked a year-long phase of public health adversaries and has severely compromised healthcare globally. Early evidence of COVID-19 noted its impact on the pulmonary and cardiovascular functions, while multiple studies in recent time shed light on its substantial neurological complications, though a comprehensive understanding of the cause(s), the mechanism(s), and their neuropathological outcomes is scarce. In the present review, we conferred evidence of neurological complications in COVID-19 patients and shed light on the SARS-CoV-2 infection routes including the hematogenous, direct/neuronal, lymphatic tissue or cerebrospinal fluid, or infiltration through infected immune cells, while the underlying mechanism of SARS-CoV-2 invasion to the central nervous system (CNS) was also discussed. In an up-to-date manner, we further reviewed the impact of COVID-19 in developing diverse neurologic manifestations associated with CNS, peripheral nervous system (PNS), skeletal muscle, and also pre-existing neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and myasthenia gravis. Furthermore, we discussed the involvement of key factors including age, sex, comorbidity, and disease severity in exacerbating the neurologic manifestations in COVID-19 patients. An outlook of present therapeutic strategies and state of existing challenges in COVID-19 management was also accessed. Conclusively, the present report provides a comprehensive review of COVID-19-related neurological complications and emphasizes the need for their early clinical management in the ongoing COVID-19 pandemic. Keywords COVID-19 • SARS-CoV-2 • CNS • PNS • Neuroinvasion • COVID-19 pandemic • Neurological complications Highlights• Coronavirus disease 2019 (COVID-19)-associated complications involve substantial neurological manifestations.• SARS-CoV-2 infection routes include the hematogenous, neuronal, lymphatic tissue/cerebrospinal fluid, or infiltration through infected immune cells.• COVID-19 promotes neurologic manifestations associated with the central and peripheral nervous system and exacerbates the pre-existing neurological and neurodegenerative conditions. • Patient's age, sex, comorbidity, and severity of the infection are key factors that determine the extent of neurologic manifestations in COVID-19 patients.

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Section: Pns Manifestationsmentioning

confidence: 99%

Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic

et al. 2021

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“…The authorities further suggest that practitioners and investigators should have GBS in mind as they manage COVID-19 patients. In another report by Bueso et al (2020) it is indicated that the ill nature of many COVID-19 patients is a challenge to distinguish GBS from the critical illness. However, few COVID-19 patients with GBS have been reported.…”

Section: Causes Of Guillain Barre Syndromementioning

confidence: 99%

Guillain-barre Syndrome: The Life Experiences of a Woman Victim in Masvingo District, Zimbabwe

Mutumburanzou¹

2022

IJARBSS

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The presentation focuses on Guillain Barre Syndrome (GBS), the rare, neurological disorder, presenting a host of life threatening complications and the lived experiences of the young woman who fell victim to this autoimmune disease while pursuing her teaching career. A review of documents and researches was done to establish what GBS is, and how best it can be managed. In depth interviews were conducted to collect data from the forty six year old woman who painfully narrated her ordeal. The diagnosis of GBS may be challenging especially that in most cases, ascending weakness is the major symptom, yet it is not always viewed seriously to warrant the attention of the medical doctor. The young woman was unfortunate in that GBS is slightly more common in older people and in males. Despite her deteriorating health, the woman struggled to complete her professional training under very harsh conditions. Results show that she suffered double discrimination due to the impact of disability and gender. It has been observed that gender based violence has become a grave reality, existing in all societies regardless of class, culture or disability. The impact of GBS on the young woman's health doomed her career. It is recommended that the woman with disability must be supported fully to be able to fulfil her dreams. GBS is associated with a variety of viral and bacterial infections hence there is need to conduct further research on whether GBS may appear in COVD 19 patients. Practitioners should have GBS in mind as they manage COVID 19 cases because limited evidence suggests that GBS appears in COVID 19 patients after several days of onset.

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Cerebrospinal fluid in COVID-19: A systematic review of the literature

Lewis

Frontera

Placantonakis

et al. 2021

Journal of the Neurological Sciences

153

152

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We sought to review the literature on cerebrospinal fluid (CSF) testing in patients with COVID-19 for evidence of viral neuroinvasion by SARS-CoV-2. Methods: We performed a systematic review of Medline and Embase between December 1, 2019 and November 18, 2020 to identify case reports or series of patients who had COVID-19 diagnosed based on positive SARS-CoV-2 polymerase chain reaction (PCR) or serologic testing and had CSF testing due to a neurologic symptom. Results: We identified 242 relevant documents which included 430 patients with COVID-19 who had acute neurological symptoms prompting CSF testing. Of those, 321 (75%) patients had symptoms that localized to the central nervous system (CNS). Of 304 patients whose CSF was tested for SARS-CoV-2 PCR, there were 17 (6%) whose test was positive, all of whom had symptoms that localized to the central nervous system (CNS). The majority (13/17, 76%) of these patients were admitted to the hospital because of neurological symptoms. Of 58 patients whose CSF was tested for SARS-CoV-2 antibody, 7 (12%) had positive antibodies with evidence of intrathecal synthesis, all of whom had symptoms that localized to the CNS. Of 132 patients who had oligoclonal bands evaluated, 3 (2%) had evidence of intrathecal antibody synthesis. Of 77 patients tested for autoimmune antibodies in the CSF, 4 (5%) had positive findings. Conclusion: Detection of SARS-CoV-2 in CSF via PCR or evaluation for intrathecal antibody synthesis appears to be rare. Most neurological complications associated with SARS-CoV-2 are unlikely to be related to direct viral neuroinvasion.

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Covid-19 Infection Complicated by Guillain-Barré Syndrome: A Case Report

Cited by 5 publications

References 0 publications

Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic

Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic

Guillain-barre Syndrome: The Life Experiences of a Woman Victim in Masvingo District, Zimbabwe

Cerebrospinal fluid in COVID-19: A systematic review of the literature

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