COVID-19 target: A specific target for novel coronavirus detection

Kakhki, Reza Kamali; Kakhki, Mohammad Kamali; Neshani, Alireza

doi:10.1016/j.genrep.2020.100740

Cited by 29 publications

(25 citation statements)

References 5 publications

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“…The most accurate investigation on individuals who are infected by Covid19, is using molecular methods such as Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) and digital PCR droplets (ddPCR) (28) and Real Time Polymerase Chain Reactions (realtime PCR) (29)(30). RT-PCR has sensitive results, but ddPCR also has good potential for detecting blood samples (28). Clinical specimens that used are nasal secretions, blood, sputum, and bronchoalveolar lavage (BAL) in individuals who are suspected of being infected with Covid19 (14).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Nasikhah

Pawitra

2020

JKL

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Introduction: WHO has announced coronavirus Disease 2019 (Covid19) as a global pandemic at the immune decline, one of which is due to chronic exposure to ambient air pollution. This literature review aims to describe the impact of ambient air pollution toward the risk of being infected by Covid19. Discussion: Covid19 can be found in a bat (host primer), and can be contagious through a person, also possible from pets. The symptoms that sufferers will perceive are fever, cough, diarrhea, myalgia, fatigue, headache, nausea, vomit, abdominal pain, loss of appetite, and some asymptomatic people. The body’s immunity affects a person’s susceptibility to Covid19 infection. The body’s immunity can be affected by ambient air pollution (with PM10, PM2,5, and O3 are the most pollutant in the air in various countries) for an extended period could be the reason for chronic illness (especially, respiratory tract) could reduce immune resistance. Furthermore, it might be happened on increasing at ACE2 activity and can cause increasing infected by Covid19. Prevention action can be done by contributing from all of the sectors at an observance in guarding, physical distancing, quarantine, and maintaining the ambient air quality in the future. Conclusion: Ambient air pollution must be considered as one effort to prevent chronic illness that can reduce immunity, which can increase the risk of being infected with Covid19. Furthermore, future studies will be carried out on ACE2 activity in people infected with Covid19 in order to get more valid results and following current conditions.

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Section: Discussionmentioning

confidence: 99%

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Nasikhah

Pawitra

2020

JKL

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“…Kakhki et al . proposed that ORF8 might serve as an excellent detection target as its sequence contains stretches of nucleotides that are wholly unique to SARS-CoV-2 [ 94 ].…”

Section: Nonstructural Proteinsmentioning

confidence: 99%

Dysregulation of Cell Signaling by SARS-CoV-2

Suryawanshi

Koganti

Agelidis

et al. 2021

Trends in Microbiology

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“…ORF8b is found to form cellular aggregates and induces cell death through ER stress and robust activation of the NLRP3 inflammasome (Shi et al, 2019). Very recently, the ORF8 gene has been considered as a novel target for identifying COVID-19 disease (Kakhki et al, 2020). Besides this, it has been demonstrated that the E protein of SARS-CoV also elicits an immune response to produce apoptosis of FIGURE 2 | Schematic representation of how coronavirus disrupts signaling pathways (autophagy, ER stress, cytokine storm, and hypoxia) and induces cell death.…”

Section: Sars-cov Induces Cellular Stress and Apoptosismentioning

confidence: 99%

Modulation of Autophagy by SARS-CoV-2: A Potential Threat for Cardiovascular System

et al. 2020

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Recently, we have witnessed an unprecedented increase in the number of patients suffering from respiratory tract illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 virus is a single-stranded positive-sense RNA virus with a genome size of ~29.9 kb. It is believed that the viral spike (S) protein attaches to angiotensin converting enzyme 2 cell surface receptors and, eventually, the virus gains access into the host cell with the help of intracellular/extracellular proteases or by the endosomal pathway. Once, the virus enters the host cell, it can either be degraded via autophagy or evade autophagic degradation and replicate using the virus encoded RNA dependent RNA polymerase. The virus is highly contagious and can impair the respiratory system of the host causing dyspnea, cough, fever, and tightness in the chest. This disease is also characterized by an abrupt upsurge in the levels of proinflammatory/inflammatory cytokines and chemotactic factors in a process known as cytokine storm. Certain reports have suggested that COVID-19 infection can aggravate cardiovascular complications, in fact, the individuals with underlying co-morbidities are more prone to the disease. In this review, we shall discuss the pathogenesis, clinical manifestations, potential drug candidates, the interaction between virus and autophagy, and the role of coronavirus in exaggerating cardiovascular complications.

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COVID-19 target: A specific target for novel coronavirus detection

Cited by 29 publications

References 5 publications

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Dysregulation of Cell Signaling by SARS-CoV-2

Modulation of Autophagy by SARS-CoV-2: A Potential Threat for Cardiovascular System

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