2020
DOI: 10.1016/j.bmc.2020.115757
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COVID-19 therapy: What weapons do we bring into battle?

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Cited by 24 publications
(23 citation statements)
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References 328 publications
(450 reference statements)
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“…Urgent COVID-19 therapeutic options are desired by the community ( de Almeida et al, 2020 ). In this regard, based on previous therapeutic experience with SARS-CoV and MERS-CoV, there has been a substantial inquisitiveness in the repurposing of approved antiviral drugs (for example, drugs used to treat HIV, HBV, HCV, filoviruses, and influenza) and development of new drugs for COVID-19 ( Artese et al, 2020 ; Liu and Wang, 2020 ).…”
Section: Discussion and Perspectivesmentioning
confidence: 99%
“…Urgent COVID-19 therapeutic options are desired by the community ( de Almeida et al, 2020 ). In this regard, based on previous therapeutic experience with SARS-CoV and MERS-CoV, there has been a substantial inquisitiveness in the repurposing of approved antiviral drugs (for example, drugs used to treat HIV, HBV, HCV, filoviruses, and influenza) and development of new drugs for COVID-19 ( Artese et al, 2020 ; Liu and Wang, 2020 ).…”
Section: Discussion and Perspectivesmentioning
confidence: 99%
“…CsA has immunosuppressive and antiinflammatory properties attributable to its ability to inhibit the transcription of genes required for T cell proliferation (including genes for IL-2). 105 , 106 On the other hand, IL-2 is reported as a potential trigger of the cytokine storm in severe COVID-19. 107 SARS-CoV nsp1 induces the expression of IL-2 via activation of nuclear factor of activated T cell.…”
Section: Repurposing Of Dermatologic Medications To Treat Covid-19mentioning
confidence: 99%
“…Acyclovir [6] Arbidol [5] Boceprevir [18] Chloroquine [5] Darunavir [5] Elvitegravir [17] Ganciclovir [5] Hydroxychloroquine [5] K-12 [16] Lopinavir [5] Favipiravir [5] Oseltamivir [5] Ribavirin [5] Remdesivir [5] Ritonavir [5] In this study are investigated five SARS-CoV-2 targets: main protease (PD ID: 6W63, PD ID: 6WNP), spike glycoprotein (closed state) (PD ID: 6VXX), chimeric receptor-binding domain complexed with its receptor human ACE2 (PD ID: 6VW1), RNA-dependent RNA polymerase (PD ID: 6M71) and 3CL protease (3CL pro) (PD ID: 6M2N).…”
Section: Molecular Docking Studiesmentioning
confidence: 99%
“…To develop new drugs with antiviral activity, the concern of many research groups is focused on the repositioning of already approved drugs [3][4][5][6] and the fastest way is to find potential drugs by molecular docking studies [7][8][9][10][11][12][13].…”
Section: Introductionmentioning
confidence: 99%