COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Reschini, Marco; Pagliardini, Luca; Boeri, Luca; Piazzini, Francesca; Bandini, Veronica; Fornelli, Gianfranco; Dolci, Carolina; Cermisoni, Greta Chiara; Viganò, Paola; Somigliana, Edgardo; Coccia, Maria Elisabetta; Papaleo, Enrico

doi:10.3389/fpubh.2022.839967

Cited by 42 publications

(61 citation statements)

References 27 publications

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“…Another study compared the changes in sperm parameters of 43 men before and after receiving the BNT162b2 mRNA Covid‐19 vaccine (Pfizer BioNTech), and found that there was no change in sperm parameters after vaccination (Safrai et al, 2022 ). Similar results were also reported by Reschini et al ( 2022 ). In a prospective cohort study conducted in Israel between February and March of 2021, semen samples from 75 fertile men were analysed 1–2 months following their second dose of Pfizer's COVID‐19 vaccine, and the sperm parameters were compared with the World Health Organization (WHO) reference ranges.…”

Section: Discussionsupporting

confidence: 92%

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

Xia

Zhao

et al. 2022

Andrologia

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Since the reproductive toxicity of COVID‐19 vaccines have not been assessed in previous clinical trials, and studies have shown that SARS‐CoV‐2 is associated with a decrease in sperm parameters. Although it has been reported that the mRNA SARS‐CoV‐2 vaccines do not adversely affect semen parameters, whether this conclusion applies to inactivated vaccines remains unclear. Here, we conducted a study among patients who accepted in vitro fertilization (IVF) at the reproductive centre between June and August of 2021. In the enrolled cases, men who have completed two doses of COVID‐19 inactivated vaccine were included in “vaccine group” (N = 105), and those who were not vaccinated were included in “control group” (N = 155). In this study, we compare the sperm parameters and embryo quality between these two groups. Our data showed that the sperm parameters were similar in terms of volume, sperm concentration, sperm count, progressive motility, total motility and total motile sperm count between these two groups. Similarly, no significant differences were observed in IVF outcomes. The mean number of 2PN, cleavage‐stage embryos, blastocysts, and good‐quality blastocysts was 8.59 ± 4.47, 5.06 ± 3.17 and 2.08 ± 1.79 in vaccine group, 7.75 ± 4.14, 4.34 ± 3.06 and 1.74 ± 1.54 in control group, respectively. The high‐quality blastocyst rate was 41.05% (218 of 531) in vaccine group and 40.03% (269 of 672) in control group (p > 0.05). In addition, no differences were observed in biochemical and clinical pregnancy rates between the two groups. In summary, our results revealed that COVID‐19 inactivated vaccine administration exhibited no negative effect on sperm parameters and embryo quality in IVF.

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Section: Discussionsupporting

confidence: 92%

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

Xia

Zhao

et al. 2022

Andrologia

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“…Several studies to date have found no association between mRNA COVID-19 vaccine and sperm parameters [9][10][11][12], follicular function [13][14][15][16][17] as well as embryo development [14,15]. With a specific focus on in vitro fertilization (IVF) cycles using preimplantation genetic testing for aneuploidy (PGT-A), one study further demonstrated similar euploidy rate after mRNA COVID-19 vaccination on adjusted analysis [17].…”

Section: Introductionmentioning

confidence: 99%

Impact of inactivated SARS-CoV-2 vaccination on embryo ploidy: a retrospective cohort study of 133 PGT-A cycles in China

et al. 2022

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Background Unsubstantiated concerns have been raised on the potential correlation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and infertility, leading to vaccine hesitancy in reproductive-aged population. Herein, we aim to evaluate the impact of inactivated SARS-CoV-2 vaccination on embryo ploidy, which is a critical indicator for embryo quality and pregnancy chance. Methods This was a retrospective cohort study of 133 patients who underwent preimplantation genetic testing for aneuploidy (PGT-A) cycles with next-generation sequencing technology from June 1st 2021 to March 17th 2022 at a tertiary-care medical center in China. Women fully vaccinated with two doses of Sinopharm or Sinovac inactivated vaccines (n = 66) were compared with unvaccinated women (n = 67). The primary outcome was the euploidy rate per cycle. Multivariate linear and logistic regression analyses were performed to adjust for potential confounders. Results The euploidy rate was similar between vaccinated and unvaccinated groups (23.2 ± 24.6% vs. 22.6 ± 25.9%, P = 0.768), with an adjusted β of 0.01 (95% confidence interval [CI]: -0.08–0.10). After frozen-thawed single euploid blastocyst transfer, the two groups were also comparable in clinical pregnancy rate (75.0% vs. 60.0%, P = 0.289), with an adjusted odds ratio of 6.21 (95% CI: 0.76–50.88). No significant associations were observed between vaccination and cycle characteristics or other laboratory and pregnancy outcomes. Conclusions Inactivated SARS-CoV-2 vaccination had no detrimental impact on embryo ploidy during in vitro fertilization treatment. Our finding provides further reassurance for vaccinated women who are planning to conceive. Future prospective cohort studies with larger datasets and longer follow-up are needed to confirm the conclusion.

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“…In a more recent study, semen parameters and fertilization rates were compared pre- and post-vaccination in patients undergoing ART. At a median follow-up of 75 days, no differences were noted between groups [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mRNA SARS-CoV-2 vaccine, introduced in late 2020, dramatically reduced COVID-19 infection and transmission with consequent decrease in hospitalization and death rates within the general population [ 7 , 8 ]. Following the implementation of the mRNA SARS-CoV-2 vaccine, several studies were conducted to explore possible adverse outcomes of the vaccine on male fertility, confirming its safety on short-term follow-up [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up

Karavani

Chill

Meirman

et al. 2022

J Assist Reprod Genet

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Purpose We aimed to investigate the possible effect of SARS-CoV-2 vaccination on sperm quality by evaluating semen analyses of men prior to vaccination and 6–14 months after vaccination. Methods This was a retrospective cohort study, conducted in a university-affiliated in vitro fertilization center between October 2021 and March 2022, including men not previously infected with the SARS-CoV-2 virus who received at least 2 doses of the Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine. Semen analyses of samples given pre-vaccination and 6–14 months post-vaccination were analyzed for the parameters of volume, concentration, motility, morphology, and total motile count (TMC) and compared. These parameters were also compared separately for men who received a third (booster) dose and for men with pre-vaccination normal and abnormal sperm. Correlations between time from vaccination and post-vaccination sperm parameters were also assessed. Results Fifty-eight men were included in the final analysis. Semen volume (2.9 ± 1.4 vs. 2.9 ± 1.6 ml), sperm concentration (42.9 ± 37.9 vs. 51.5 ± 46.2 million/ml), motility (42.5 ± 23.1 vs. 44.3 ± 23.4 percent), morphology (8.8 ± .16.6 vs. 6.6 ± 8.8 percent), and TMC (55.7 ± 57.9 vs. 71.1 ± 77.1 million) were comparable between the pre- and post-vaccination samples. This was true for the entire study cohort, for the subgroup of men who received a third dose and for the subgroups of men with a pre-vaccination normal and abnormal semen samples. No correlation was found between time from vaccination and post-vaccination sperm parameters. Conclusions The Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine does not impair any of the sperm parameters over a relatively long-time interval of 6 to 14 months from vaccination. Supplementary Information The online version contains supplementary material available at 10.1007/s10815-022-02621-x.

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COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Cited by 42 publications

References 27 publications

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

Impact of inactivated SARS-CoV-2 vaccination on embryo ploidy: a retrospective cohort study of 133 PGT-A cycles in China

Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up

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