COVID‐19 Ventilatory Phenotypes and Obesity: Is There a Relationship?

Costa, Hugo; Jacob, Miguel; Pereira, Rafaela; Calças, Roberto; Núñez, Daniel

doi:10.1002/oby.22877

Cited by 9 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Optimizing levels of PEEP is a well-documented approach for ARDS especially in obese patients. 14,15 Our findings that obese patients required higher levels of PEEP is congruent with established evidence that PEEP mitigates the effect of obesity on respiratory mechanics, namely reduced lung compliance and decreased reserve. Advanced ARDS management strategies, however, were not required at a greater frequency in the obese patients.…”

Section: Discussionsupporting

confidence: 85%

“…Optimizing levels of PEEP is a well-documented approach for ARDS especially in obese patients. 14,15 Our findings that obese patients required higher levels of This analysis included one healthcare system, therefore limiting the generalizability. The sample size was too small to show a statistically significant impact of obesity in the presence of risk factors such as age and male sex.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

ICU outcomes in Covid-19 patients with obesity

Parikh

Garcia

Rajendran

et al. 2020

Ther Adv Respir Dis

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 96%

ICU outcomes in Covid-19 patients with obesity

Parikh

Garcia

Rajendran

et al. 2020

Ther Adv Respir Dis

View full text Add to dashboard Cite

show abstract

“…The coronavirus disease 2019 (COVID-19) was caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ( 1 ). The mild to moderate form of COVID-19 illness is associated with cough, fever, and fatigue.…”

Section: Introductionmentioning

confidence: 99%

“…The mild to moderate form of COVID-19 illness is associated with cough, fever, and fatigue. However, if a severe course of COVID-19 disease is present, it can lead to pneumonia, respiratory failure, multiorgan failure, and ultimately death ( 1 , 2 ). The number of global deaths associated with COVID-19 disease increased to 4.86 million confirmed deaths by mid-October 2021 ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Patients With Super Obesity Do Not Perceive Themselves as Being at Higher Risk for a More Severe Course of COVID-19 Infection

Schäffeler¹,

Lohmiller²,

Mack³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has led to major health-related concerns in the population. Several risk factors for a severe course of COVID-19 disease have been identified, with obesity taking an important role. However, it is unclear whether this association is only known in the expert world or whether individuals also experience themselves as risk patients due to their obesity and whether the desire for weight reduction may also be associated with a hoped-for risk reduction. These questions were addressed in a cross-sectional study of patients who have presented to an obesity center in order to lose body weight.MethodsPatients (n = 155) of the obesity center were asked to complete an ad hoc questionnaire to assess whether the desire to lose weight is also associated with a hoped-for risk reduction with respect to COVID-19 disease during the middle of the pandemic in the period between October 2020 and April 2021. We additionally assessed their perceived general stress using the Perceived Stress Questionnaire (PSQ).ResultsIn our explorative study, overall worries correlated significantly with worries about contracting COVID-19 (r = 0.483, p < 0.001). There has been an association with concerns about severe COVID-19 progression and psychological distress from the COVID-19 pandemic (r = 0.543, p < 0.001). In addition, a correlation was found between persons who worry about contracting COVID-19 and feeling like an at-risk patient (r = 0.530, p < 0.001). Interestingly, the higher the BMI (>50 kg/m2), the lower were the worries in PSQ (ANOVA p = 0.046). However, COVID-19-related worry was nonetheless present in the higher BMI subgroups. The most intense worries were experienced by individuals with a BMI between 35 and 39 (PSQ worries 50.44), immediately followed by individuals with a BMI between 40 and 49 (PSQ worries 49.36).Discussion and ConclusionAn increased risk for a more severe course of COVID-19 infection is not generally perceived by obese individuals. In particular, individuals with very high BMI (>50)—although being at very high risk for a severe course of the COVID-19 disease—do not display increased worries, which might point toward heightened denial.

show abstract

“…ОРДС и острое повреждение легких (ОПЛ) являются основными причинами смертности пациентов, инфицированных SARS-CoV-2. ОРДС и ОПЛ характеризуются острой дыхательной недостаточностью (ОДН), что приводит к тяжелому разобщению ВПО и гипоксемической ОДН, требующей протезирования функции внешнего дыхания -респираторной поддержки с положительным давлением конца выдоха и высокой фракцией кислорода во вдыхаемой газово-воздушной смеси [35]. Следовательно, ожирение повышает риск развития ОРДС и ОПЛ у пациентов COVID-19.…”

unclassified

Covid-19 and Lung Damage in Obese Patients

Kuligin¹,

Zeulina²,

Panchenko³

et al. 2021

СПНО (MPSE)

View full text Add to dashboard Cite

Ожирение -прогностически неблагоприятный фактор тяжелого течения острой респираторной вирусной инфекции, поскольку патологические процессы, связанные с нарушением липидного обмена, усиливают иммунологическую дисрегуляцию. Ведущими факторами взаимоотягощения поражения легких у пациентов с ожирением при острой респираторной вирусной инфекции являются нейрогуморальные, иммунологические и метаболические дисфункции, проявляющиеся нарушением газообмена в легких. Целью обзора явилось формирование представления о частоте и тяжести поражения легких при COVID-19 у пациентов с ожирением. Научный анализ высокоиндексированных международных докладов, статей и клинических протоколов. Критерии включения в анализ: исследования, опубликованные на английском языке; исследования, изучающие связь между поражением легких при ожирении или избыточным весе и COVID-19; когортные исследования с проспективным или ретроспективным дизайном. Критерия исключения из анализа: дублирование исследований; исследования, в которых отсутствовали данные. Выявлены многообразие и неоднозначность данных о частоте и тяжести поражения легких при COVID-19 у пациентов с ожирением. Однако, несмотря на высокий риск поражения легких при COVID-19 у пациентов с ожирением, риск смерти может быть снижен ввиду потенциально уравновешивающих эффектов ожирения и наличия повышенного метаболического резерва. Поскольку изученные данные свидетельствуют о многообразии и противоречивом представлении о частоте и тяжести поражения легких при COVID-19 у пациентов с ожирением, необходима дальнейшая проработка выбранного направления с привлечением авторитетных научных групп для получения окончательных выводов. При этом, учитывая полученные в условиях настоящей пандемии COVID-19 данные, следует уделять особое внимание реализации персонализированного подхода в оказании медицинской помощи пациентам, страдающим ожирением и избыточным весом. Ключевые слова: COVID-19, ожирение, поражение легких.

show abstract

COVID‐19 Ventilatory Phenotypes and Obesity: Is There a Relationship?

Cited by 9 publications

References 4 publications

ICU outcomes in Covid-19 patients with obesity

ICU outcomes in Covid-19 patients with obesity

Patients With Super Obesity Do Not Perceive Themselves as Being at Higher Risk for a More Severe Course of COVID-19 Infection

Covid-19 and Lung Damage in Obese Patients

Contact Info

Product

Resources

About