COX inhibition reduces vasodilator PGE<sub>2</sub> but is shown to increase levels of chemoattractant 12‐<scp>HETE </scp><i>in vivo</i> in human sunburn

Pilkington, Suzanne M.; Murphy, Sharon Ann; Kudva, Shobha; Nicolaou, Anna; Rhodes, Lesley E.

doi:10.1111/exd.12734

Cited by 12 publications

(11 citation statements)

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“…In their recent study, Pilkington et al . provide evidence that COX‐2‐ versus 12‐LOX‐driven generation of arachidonic acid metabolites in UV‐irradiated human skin is tightly balanced. Specifically, the authors determined the time dependence of UVR‐induced production of PGE 2 and 12‐HETE in the skin (i.e.…”

mentioning

confidence: 87%

“…The results by Pilkington et al . may help us to better understand the role of eicosanoids in UV‐irradiated skin. Whereas the vasodilatory effects of COX‐2 produced PGE 2 may significantly contribute to the acute symptoms of extensive UVR exposure, especially the erythemal response, its anti‐apoptotic action significantly contributes to the survival and accumulation of damaged cells and finally to skin carcinogenesis.…”

mentioning

confidence: 99%

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COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

Nakamura

Haarmann‐Stemmann

Krutmann

2015

Experimental Dermatology

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confidence: 87%

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confidence: 99%

COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

Nakamura

Haarmann‐Stemmann

Krutmann

2015

Experimental Dermatology

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“…Indeed, DESI‐MSI and MALDI‐MSI studies could be targeted to analyse a selection of lipids identified through UPLC/ESI‐MS/MS or UHPSFC/ESI‐QToF, to investigate whether their distribution throughout the skin changes as well as their abundance, whilst lipid ions identified through lipid imaging could be followed up with more targeted analysis for improved sensitivity. Lipid analysis can reveal diverse information about cutaneous lipid biology, from mechanistic insight into inflammatory skin conditions such as sunburn and irritant dermatitis, to the effects of topical treatments and nutritional supplementation on the skin lipidome, revealing biomarkers, unravelling complex signalling pathways and identifying potential therapeutic targets. As mass spectrometry technology continues to improve, resulting in increased mass accuracy, sensitivity, spatial resolution and more, we expect skin lipidomics to become a routine consideration in the investigation of cutaneous homoeostasis and inflammation.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Lipidomics for translational skin research: A primer for the uninitiated

Kendall

Koszyczarek

Jones

et al. 2018

Experimental Dermatology

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Healthy skin depends on a unique lipid profile to form a barrier that confers protection and prevents excessive water loss, aids cell-cell communication and regulates cutaneous homoeostasis and inflammation. Alterations in the cutaneous lipid profile can have severe consequences for skin health and have been implicated in numerous inflammatory skin conditions. Thus, skin lipidomics is increasingly of interest, and recent developments in mass spectrometry-based analytical technologies can deliver in-depth investigation of cutaneous lipids, providing insight into their role and mechanism of action. The choice of tissue sampling technique and analytical approach depends on the location and chemistry of the lipid of interest. Lipidomics can be conducted by various mass spectrometry approaches, including different chromatography and ionisation techniques. Targeted mass spectrometry is a sensitive approach for measuring low-abundance signalling lipids, such as eicosanoids, endocannabinoids and ceramides. This approach requires specific extraction, chromatography and mass spectrometry protocols to quantitate the lipid targets. Untargeted mass spectrometry reveals global changes and allows analysis of hundreds of complex lipids across a range of lipid classes, including phospholipids, glycerophospholipids, cholesteryl esters and sphingolipids. Mass spectrometry lipid imaging, including matrix-assisted laser desorption ionisation mass spectrometry and desorption electrospray ionisation mass spectrometry, can reveal information about abundance and anatomical distribution of lipids within a single skin sample. Skin lipidomics can provide qualitative and quantitative data on hundreds of biologically relevant lipid species with different properties and activities, all found within a single skin sample, and support translational studies exploring the involvement of lipids in skin health and disease.

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“…UVB radiation can exaggerate the Cox enzyme to increase PGE 2 synthesis that leading the process of inflammation along with the existence of erythema and sunburn. 8 Besides that, UVB radiation also causing DNA damage directly and indirectly. The damage on DNA results the skin cancer .…”

Section: The Protection Againts Uvb-induced Immunoupressionmentioning

confidence: 99%

“…UVB can activate the production of TNFα and proinflammatory sitokin agent such as IL-1, IL-6 which can increase the process of melanogenesis. 8 The further effect of the oxidative damage can generate DNA mutation and carcinogenesis. 9 The result of this research is similar to previous study that shows that bixin isolated from B. orellana L. seeds has the effectiveness of antioxidant in quencher ROS.…”

Section: The Protection Againts Uvb-induced Immunoupressionmentioning

confidence: 99%

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

Hussaana

Suparmi

Murti

2018

Bangladesh J Med Sci

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Background: DNA damage caused by excessive ultraviolet B (UVB) radiation on the skin triggers the response to inflammatory and immunosuppression. The bixin from Bixa orellana L. has been proven to be able to inhibit cyclo-oxygenase. Objective: to verify whether the bixin lotion has the effect to offer protection against inflammation and immunosuppression due to acute UVB irradiation in shaved BALB /c mice. Methods: Protection against inflammation and immunosuppression, respectively were studied in 4 groups of mice. Each group was treated respectively with topical application of base lotion as a control; bixin lotion doses of 0.5 mg; 2.5 mg and 125 mg, for 10 days prior to and during the UVB irradiation. The Inflammation was induced by UVB irradiation, 360 mJ/cm2 once a day for 3 consecutive days, whereas the immunosuppression was induced by UVB irradiation, 360 mJ/cm2 once a day for 5 consecutive days. The inflammatory response was measured as an increase in middorsal skinfold thickness at the peak response. The immune response was measured as the contact hypersensitivity (CHS) response to oxasolon sensitization. Results: The results indicated that in concentration range used, bixin lotion significantly decreased the middorsal skinfold thickness at 72 hours after UVB radiation (p <0.05) compared to the control, but there was no significant difference between couples of the dose of bixin. Bixin lotion was also capable to restore the suppression of CHS from 34.22% in the control group to 11.4%; 0.5% and 0% at doses of 0.5; 2.5 and 125 mg respectively (p <0.05). Conclusion: Bixin lotion has the potential to reduce the inflammatory edema reaction and the suppression of CHS of mice induced by UVB radiation. Bangladesh Journal of Medical Science Vol.18(1) 2019 p.107-111

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COX inhibition reduces vasodilator PGE₂ but is shown to increase levels of chemoattractant 12‐HETE in vivo in human sunburn

Cited by 12 publications

References 10 publications

COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

Lipidomics for translational skin research: A primer for the uninitiated

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

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COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12‐HETE in vivo in human sunburn

Cited by 12 publications

References 10 publications

COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

COX inhibition enhances inflammatory immune cell infiltration in UV‐irradiated human skin: implications for the treatment of sunburn

Lipidomics for translational skin research: A primer for the uninitiated

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

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COX inhibition reduces vasodilator PGE₂ but is shown to increase levels of chemoattractant 12‐HETE in vivo in human sunburn