COX7B Is a New Prognostic Biomarker and Correlates with Tumor Immunity in Esophageal Carcinoma

Abstract

Esophageal carcinoma (ESCA) refers to the most common type of malignant tumor, which reveals that it occurs often all over the world. ESCA is also correlated with an advanced stage and low survival rates. Thus, the development of new prognostic biomarkers is an absolute necessity. In this study, the aim was to investigate the potential of COX7B as a brand-new predictive biomarker for ESCA patients. COX7B expression in pancancer was examined using TIMER2. The statistical significance of the predictive value of COX7B expression was explored. The relationship between COX7B expression and tumor-infiltrating immune cells in ESCA was analyzed by using ssGSEA. In this study, the result indicated that several types of cancers had an abnormally high amount of COX7B. COX7B expression in samples from patients with ESCA was considerably higher than in nontumor tissues. A more advanced clinical stage may be anticipated from higher COX7B expression. According to the findings of Kaplan-Meier survival curves, patients with low COX7B levels had a more favorable prognosis than those with high COX7B levels. The result of multivariate analysis suggested that COX7B expression was a standalone prognostic factor for the overall survival of ESCA patients. A prognostic nomogram including gender, clinical stage, and COX7B expression was constructed, and TCGA-based calibration plots indicated its excellent predictive performance. An analysis of immune infiltration revealed that COX7B expression has a negative correlation with TFH, Tcm, NK cells, and mast cells. COX7B may serve as an immunotherapy target and as a biomarker for ESCA diagnosis and prognosis.

Identification of sepsis-associated mitochondrial genes through RNA and single-cell sequencing approaches

“…COX serves as the terminal enzyme complex of the mitochondrial respiratory chain, orchestrating the movement of electrons from the reduced form of cytochrome c towards oxygen. Disorders intertwined with COX7B encompass Linear Skin Defects with Multiple Congenital Anomalies [27]. Its associated pathways encompass respiratory electron transport, ATP synthesis coupled electron transport, and uncoupling protein-mediated heat production.…”

“…Its associated pathways encompass respiratory electron transport, ATP synthesis coupled electron transport, and uncoupling protein-mediated heat production. In the oncological realm, investigations have unveiled a correlation between COX7B expression and infiltrative immune cells in esophageal carcinoma [27]. Within septic research, proteins within the COX family are essential.…”